Conserved Protein Domain Family
7tmA_P2Y14
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cd15149: 7tmA_P2Y14 
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors
The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.
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Statistics
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PSSM-Id: 320277
Aligned: 3 rows
Threshold Bit Score: 444.676
Created: 18-Nov-2008
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on the binding of human P2Y12 receptor to full agonist 2-methylthio-adenosine-5'-diphosphate (2MeSADP, a close analogue of endogenous agonist ADP)
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracellular surface of its receptor.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                           #   #   ##  #
Q15391        23 QIIPVLYCMVFIAGILLNGVSGWIFFYVPSsksFIIYLKNIVIADFVMSLTFPFKILGDSglGPWQLNVFVCRVSAVLFY 102 human
XP_002941150  23 RVLPVFYSLVFIVSIILNGLNFWIFFYVPSnrsFIVYLKNIVFADLLMTLTLPLKIVSDVelGSALLNIIVCRYTAVIFY 102 western clawed ...
XP_007057435  22 HVIPLAYGFVFIGGILLNGVAAWIFLHVPSkksFVVYLKNIVAADLLMSLTFPFKILSDAeiGPWQLNVIVCRYSAVIFY 101 green sea turtle

Feature 1        #  #                                          #  ##  #   #          ##   #      
Q15391       103 VNMYVSIVFFGLISFDRYYKIVKPlwTSFIQsvSYSKLLSVIVWMLMLLLAVPNIILTNqsvrevtqIKCIELKselgrK 182 human
XP_002941150 103 LNMYIGIIFLGILGLDRYQKVVRPmhTSSVQnvGYSKALSAVVWMFMAVVSVPNMILTNqpfhaanyTNCARLKshlgiQ 182 western clawed ...
XP_007057435 102 LNMYVGITFFGLIGFDRYYKIVKPllTSFVHtvNYSKIVSVAIWALLMFLSLPNIILTNqspteknsKKCVNLKselglQ 181 green sea turtle

Feature 1         #  ##  #                                                             #  #   #  
Q15391       183 WHKASNYIFVAIFWIVFLLLIVFYTAITKKIFKshlkssrnstSVKKKSSRNIFSIVFVFFVCFVPYHIARIPYTKSQte 262 human
XP_002941150 183 WHQASNYICVSVFVVVFFLLVIFYVSISRTIYKsnqrf-kngsNMKAKSSRNIYSILFVFFVCFVPYHALRIPYTLSQvg 261 western clawed ...
XP_007057435 182 WHKASSYICLGIFWTVFLLLIIFYSAISRKIYSsyrkfrrnstVTREKINRNIFSIMFVFIICFVPYHLCRLPYTLSQtg 261 green sea turtle

Feature 1                      #                             
Q15391       263 ahyscqskeiLRYMKEFTLLLSAANVCLDPIIYFFLCqpFREIL 306 human
XP_002941150 262 adyscssktiLYSMKEVTLLLAASNVCLDPIIYFFMCqpFRNML 305 western clawed frog
XP_007057435 262 sqfscqssknLFYAKEFTLLLSAANVCLDPIIYFFLCkpFREKL 305 green sea turtle

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