6SPP,5URB


Conserved Protein Domain Family
MetG

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COG0143: MetG 
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Statistics
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Structure
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COG0143 is classified as a model that may span more than one domain.
COG0143 is the only member of the superfamily cl33774
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6SPP_A        26 KKILVTCALPYANGSIHLGHML-EHIQADVWVRYQ--RMR-G-HEVNFICADDAHGTPIMLKAQQ------LGITPEQMI 94 
WP_012240839  22 KRMVVTAGMPYANGPLHLGHLAgAQLPADIYARWC--RMLiGaENVLYVCGTDEHGSTSEIAAVQ------AGLPIREYI 93 
WP_012955761   2 TKIFISCALPYANGPCHLGHLRsTYIPADIYARYN--RMA-G-NDVLMVCATDEHGTPIAVKADA------EGKKPIEVA 71 
WP_013183187 121 RNTLIFSTPPTPNGDLHLGHLSgPYLAGDVLKRVL--LQS-G-TSVHHGTGRDDNQTYVVTSAAK------EQRQPTESA 190
WP_083790783   3 LKIFVTCALPYANGPLHLGHLRsTYIPADIYSRYQ--RMV-G-NDVLFVCATDEHGTPIAVKAEK------EGKDPLEIT 72 
AKV00353      22 RRAVVTAGMPYANGPLHLGHLAgAHVPADIHARWM--GLLiGrENVLFVCGTDEHGSTSELSALK------AGKPIREFV 93 
WP_010876226   2 SKVFITCALPYANGPTHLGHLRsTYIPADIYARYR--RLR-G-DDVLFVCATDEHGTPIAVKAEA------EGRTPLEVA 71 
WP_012240690  22 RRAVVTAGMPYANGMLHLGHLAgAHVPADIHARWL--GLViGrENVLFVCGTDDHGSASQIAARQ------AGVSIREFI 93 
WP_102243018  23 KTAIVTGGMPYANGPLHLGHMAgAIIPPDIMARYM--RMLiGkQNVLFVSGNDDHGSTSEASAFK------AGIPVREFI 94 
WP_124786066  15 RRAIVTAGEPYGNKGLHFGHVGgVFVPADFFARFLrdRLG-R-ENVIFTSGTDCYGSPIMESYRKlkenegYDKSIGEYV 92 
6SPP_A        95 GEMSQEHQTDFAGFNISYDNYHSTH----SEENRQLSELIYSRLKENGFIKNRTISQLYDPEKGMFLPDRFVKGTCP--K 168
WP_012240839  94 DRIQQAQKKTLERYCISLDAFTGTSqpetFPLQRELAHEFLTRFSRNGLLEKRATRQWFDPKMGRFLPDRYVRGRCPnpQ 173
WP_012955761  72 KRYHDMIARDIESCDISLDNFARTS----DELHYKISQDFFLYLYEKGLIYEEAIQQLYCENCEKFLPDRYVEGICP--V 145
WP_013183187 191 DFYASAINETWQGFGIDFDLFITPDn---QGEYADFVHHYIELLYKKDFIYEKETTA-YVDHHGNTLHEAYIHGLCP--Y 264
WP_083790783  73 TKYYKKIKSDLDKCDISFDNFSRTS----SDIHYKVAQNFFLKLYKKGYIYEKEIKQFYCTNCKRFLPDRYVEGICP--Y 146
AKV00353      94 DTIHDQQAKTLQRYSVGLDTYTGTSrpecFPIHAKLCQDILRQLRDHGLLEKRSSRQWFDPKVQRFLPDRFVRGRCPnpK 173
WP_010876226  72 TRYHEMIRGDLERCDISFDSFTRTT----DELHHEIAQKFFLKLYEKGFIYEKDIKQLYCGDCQRFLPDRYVEGTCP--Y 145
WP_012240690  94 DGIHEKQHASLRRYDIDLDVYSGTSrpecLPIQQELAHRFLRRLHDNGLLEKRTSSQWFDPELQCFLPDRFVRGRCPnpK 173
WP_102243018  95 DQIHDKQVQTVTRYSISYDIFSGTSqpdcYPTHKEVCQDFMQRLWDNKMLEKKITKQWYDPKISRFLQDRNVTGKCPnpN 174
WP_124786066  93 ESNHSRQAATLNNYNISCDIYGGSGlepaAQIHNEVTAEIIERLHEQGTISKRSTLQFYDAKAGTFLNGRQVIGRCPiqG 172
6SPP_A       169 CKSPDQYGDNCEvCGATYSPTELIEPKSVVSGATPVMRDSEHFFFDLPSFSEMLQAWTRS----Ga-LQEQVANKMQEWF 243
WP_012240839 174 CDNEDAYSDECDrCGQQHAPAALLNPRSTLSDAVPELRETVHWWLDMWSVSETLREWISGk---EktWRRAMLSEVLETV 250
WP_012955761 146 CGA-EARGDHCEsCGRALEPTELLEPHCLTCGNTPVIRDSTQYFFKLSHFQNQLEEYITTn---Ey-LPPNVRNYAQNWL 220
WP_013183187 265 CEE-SSDGNACEaCGRPNECTDLKQPQVKADGNQPLSRKEFRLYFRLSAFAHQLAQYVQTa---N--MPAHVHQLCHDML 338
WP_083790783 147 CDSEGARGDHCEvCGRHLEVLELIKPRCILCSGEPEIRKSKHYFFKLSKFQKKLKEWVENn---Ee-LPSNVKNYTLEWL 222
AKV00353     174 CENEDAYSDECDrCGHQHSPEDLIRPRSTISDATPEMRETVHWFLDMSKVSETMREWLEGk---KktWRSSVLSGVLDTV 250
WP_010876226 146 CGSEGARGDHCEgCGRHLEPLQLEDPRCMVCGSEPEVRDSRHYFFRLNQFQDEIREWIEGs-----eMPSNVRNYAIQWL 220
WP_012240690 174 CDNGDAYSDECDrCGHQHSPSQLGSPRSALSDATPVMRDTAHWWLDMWAVSETLRGWIQGk---QgaWRPAVLADVLNTV 250
WP_102243018 175 CANTSAYSDSCEvCGTQYDPSELINPKSSLSDATPELRDTAHLWLDMWKVSDQLTDWIKTk---QnkWRKGVFNEVFETV 251
WP_124786066 173 CKSEKSYADECD-LGHQFEPEELIAPKSQLTGEVPELRPVDNLYFDLPAYLDFMKTYTAKlaqnPq-VRSVVSKTMEEWL 250
6SPP_A       244 ---------------------------------E---------------------S-G--------LQQWDISRDAPYfG 260
WP_012240839 251 mpsvrldraheatyke-ikaslpkhksklargkElvvqfgnkad--lesgraileQhGvrvelvdeWAHRSITRDIGW-G 326
WP_012955761 221 ---------------------------------K---------------------E-G--------LEDWIMTRDMKW-G 236
WP_013183187 339 ---------------------------------S---------------------Q-Q--------LPDICISHASHW-G 354
WP_083790783 223 ---------------------------------K---------------------E-G--------LNDWIMTRDMKW-G 238
AKV00353     251 mpslrfagehepayke-lkaslpkhkskyapgkQvvlqftnrad--ldtararlkDsGidseladgWAHRSITRDIAW-G 326
WP_010876226 221 ---------------------------------R---------------------E-G--------LKDWILTRDMEW-G 236
WP_012240690 251 mpslrfeadlaptyke-ikaslpkhkakftqdrKvllqlgskpe--meearaalsRhGvpsepvedWAHRAITRDVAW-G 326
WP_102243018 252 qpafqfdnthepafke-mrttlpkhksryapgkKvvvqfenlnd--yatgkkaleDkSiacealdgWAHRSITRDVTW-G 327
WP_124786066 251 lpaqlyiqnkfreafdavedqlpehtvlepegnKssftvtfpswkerddahavlaNgGvrfrsgkaLVPFRITGNIDW-G 329
6SPP_A       261 F--EIP-----NAPGKYFYVWLDAPIGYMGSFKNLCD---KR---------------G---------------D-S-VSF 298
WP_012240839 327 I--PIte--dpDLAGKTLYVWPDSLIAPISFSKVALR---DK---------------G---------------VdP-ARY 368
WP_012955761 237 I--PVPl---eGAKGKVIYVWGEAFIGYISSAAAWSR---RT---------------G---------------I-P---W 274
WP_013183187 355 IkhRLP-----NYEQQVVYVWFEMAMGYLWAASEYpT---SR---------------G---------------NnRmEKA 396
WP_083790783 239 V--PVPl---eDAEGKVIYVWGEAFLGYISSAIEWSK---KN---------------K---------------K----DW 276
AKV00353     327 V--PVPee-etDLAGKTLYVWPDSLIAPISFSRVALT---QR---------------G---------------EnP-ERY 369
WP_010876226 237 V--QVPl---eGNEGKIIYVWGEAFLGYISSAAAWSK---KT---------------G---------------R----DW 274
WP_012240690 327 L--SLPadldpELCGKTLYVWPDSLIAPIAFSQVALA---RR---------------G---------------VdP-ARY 370
WP_102243018 328 I--PVPegidpEMKGKTLYVWPDSLIAPISFTRVALA---KQ---------------G---------------RdP-KEW 371
WP_124786066 330 V--PVPev--dGVNDVTCWCWPESLWAPISYTRTVLArdaKAagvtegvaaqdaalmGepaadstqvpaptyqHsS-LDW 404
6SPP_A       299 DEYWkKDSTAELYHFIGKDIIYFHSLFWPAMLEGS----------N--FRKpsNLFVHGYVTVNGAKMSKSRG-TFIKAS 365
WP_012240839 369 ADFW-RDPEARVVQFLGQDNVYFYVLMQGAMWLGTqedprrlpaaGe-LQLt-DVFGCFHLLVGGEKMSKSRG-NFFTGD 444
WP_012955761 275 EDYW----DGHVVHFIGKDIIYHHSLFWPAMLMGH----------D--CKLpdDIFAGEFLSLEGRKMSTSKN-WVVWVS 337
WP_013183187 397 ADVY--SGDTNIVHCYGFDNAYYHTLLFPAIYFAL----------G--LTPpqTHIVNELLDLEGSKFSTSRR-HLIWGK 461
WP_083790783 277 KEYW----DSGAIHFIGKDIIYHHTIFWPAMLMAY----------G--CKLprTVIAGEYLSLEGKKMSTSKN-WVVWVS 339
AKV00353     370 AEFW-RDPEARIYQFLGQDNVFFYVLMQGALWLGTqsditrlpvaGd-LQLt-EIFGCFHLQVGGQKMSKSLG-NFFTGD 445
WP_010876226 275 REYW----DSGAIHFIGKDIIYHHAIFWPALLMAY----------G--CRTpaNIIAGEYLSLEGQKMSTSKN-WVVWTS 337
WP_012240690 371 VDFW-CDPEARIYQFLGQDNVFFYVLMQGAMWLGAqpdprrlpapGe-LQLt-DVLGCFHLLVGGDKMSKSRG-NFFTAD 446
WP_102243018 372 ERFW-KDPEARIFQFLGQDNVYFYVLMQGAMWIGVrgsd------tqdYTMt-DVYSVFHLMVNGEKMSKSTG-NYYTGD 442
WP_124786066 405 RDWW-CSDDAQIYQFIGQDNIYFYCIAQTAMWEAL----------GwdLTQs-TVSACYHLLYMGKKASSSSQtPPPPAD 472
6SPP_A       366 TWLNH--FDADSLRYYYTAKlSSRIDDIDLNLEDFVQRV-------------------------NADIVNKVVNLASRNA 418
WP_012240839 445 QLLDEkgYSVDQIRYYLALL-SLAEKPSDFDFEKLDER--------------------------NKFLAGPMNAAFERPI 497
WP_012955761 338 DFVKD--FESDLLRFYLTIS-APLNKDTDFSWDDFGRRV-------------------------NDELADIIGNFLHRTF 389
WP_013183187 462 DFLKL--AGADYARMALILM-RPEGIRENFSVERVAATM-------------------------NALFPQRLSHWLSSLQ 513
WP_083790783 340 DFLKR--FDSDLLRYYLTIN-APLTRDTDFSWDDFQRRV-------------------------NDELADILGNFIHRAL 391
AKV00353     446 QLLDEkgYEADQIRYYLALL-GLAEKQSDFEFAKLDER--------------------------NKFLAGPLNAAFERPI 498
WP_010876226 338 DFLER--FDRDLLRYYLTVN-APLTRDTDFSWDDFQRRV-------------------------NDELADVLGNFLHRTF 389
WP_012240690 447 QLLDEkgYSADQIRYYLALL-GLAEKPSNFDFEKLDER--------------------------NRFLAGPLNAAFERPI 499
WP_102243018 443 QLTEEmgYHPDQLRYFLSTL-SLAEKQSNFDFETFKER--------------------------NKFLAGPLNAAIEKPI 495
WP_124786066 473 DLLNH--YTCEQMRAHWLSL-GLSEKPVSFSPKAYDTRVtgkdkdgnevracddkrvidpalkeSALLTGVFNRLARSCF 549
6SPP_A       419 GF-INKRF------DGVLas----eLADPQLYKTFTDAAEVIGEA--WESREFGKAVREIMALADLANRYVDEQ-APWVV 484
WP_012240839 498 SA-VHSKF------GGKVpeg---allD-KVVADTVRIVQRYVRA--MDRADYPNLLFEIENYARTINSLFTQY-KPHDD 563
WP_012955761 390 TF-THKFF------DGKVpeyanpsEEDLEFEAEIKELPAKVGEL--ISSMKFREGLVEILKTAKSANKYFNDQ-EPWKA 459
WP_013183187 514 EC-VMRy-------GGKIpesgawlADQKNhYyELLHVMTSYQHFsqTENFSPRRMAEHVTKLIDMAYRFNASQ-RHLFP 584
WP_083790783 392 MF-TYRFF------DAKIpepsefgEKDIEFEERIKESPKIVGNF--IENFKFRDGLIEIMKLARDGNKYFNDQ-EPWKT 461
AKV00353     499 SA-AHSKF------GGRVpeg---vliE-KVVADTVRIVQRYVKS--MDRADHPNLLFEIENYARTINSLFTQY-KPHDD 564
WP_010876226 390 SF-TGRFF------DGRVpaageltAEDLEFLESIRAAHDTVAEL--LDKFQFRDALMHIIKLAKRGNKYFNDQ-EPWKA 459
WP_012240690 500 SA-AHSKF------DGRVphg---allD-KVAADTLRIVQRYVRA--MDRADYPTLLFEIENYARVINSLFAQF-KPHDD 565
WP_102243018 496 AA-VHSKF------GGVVpng---kllE-KAEKETMKIVQMYVKN--MEKADHITLLGQIENYARLINSFFVQY-KPHDD 561
WP_124786066 550 YGvAVKEGdespyrNGCIpa----gAASDTVVEAAQQAALAFEQD--MYKFETHRALAVCDDYLRAANKRWSDAsKAANK 623
6SPP_A       485 AKQe-G--RDAdLQAICSMGINLFRVLMTYLKPVLPKLTERAEAFLNTEl----TWDGIqqpLL------------GHKV 545
WP_012240839 564 RHP-----EQG-RRDALYTSFYVLKTLMIMLYPFVPETMDRLRASLRLPpe-vfRLEELg-tPIp----------aGHEI 625
WP_012955761 460 VKE--N--PQK-ASNCLYLSNQFCKSLAILLKPYIPNKADAICDIINISke--nVWDDAs-iFLe----------nGHEI 521
WP_013183187 585 RNS--NalSNY-ARTALALDVLAARMLVYALKPLMPALSADIAALLRINat-eeTWQQAt-tFLa----------sQHMI 649
WP_083790783 462 FKE--N--KYK-AATCIYLCDQAVKAIGVLIKPYLPKTSSNILSMLNLDdn--vRWEDAn-eFIe----------pNHKI 523
AKV00353     565 RHP-----EES-RRNALFTAFYVLKNLMIMLYPFVPSTMERLRESLRLPad-vfRIDELg-tPIp----------aGHEL 626
WP_010876226 460 VKE--S--PAR-ASTCLHLCNLLAANLGKLLRPFMPSAAGRILSIMNLEd---eAWGFH---ELr----------eGQVI 518
WP_012240690 566 RHP-----EEG-RRDALFSSFYVLKNLMIMLYPFVPTTMDRLRESLRLPpe-vfRLDELg-tPIp----------aGHAI 627
WP_102243018 562 RHD-----ETE-RADGLYSCFYILKNLMIMLHPFVPETMDKVRVSLNLPes-ifSIDELg-qAIp----------aGHAI 623
WP_124786066 624 LEGepA--NAA-MTQALVDAFTELRVATVLMHGIVPAGCELICEYFDIDpvaffSWDNIf-aSTdefveslgekpgEHRV 699
6SPP_A       546 NPFKA---LYNRIDmRQvealV 564
WP_012240839 626 GAKQP---YFPAPSrEGet--- 641
WP_012955761 522 NKAKP---LFKKIEdKVieaqK 540
WP_013183187 650 QPHKI---MLPELSaTGlgqlM 668
WP_083790783 524 NKPKP---LFSKIKsEViekeK 542
AKV00353     627 GPKGT---YFPAVAaEGhe-pT 644
WP_010876226 519 ERAKP---LFSKITdEAieeeK 537
WP_012240690 628 GPKQV---YFPPVPeE------ 640
WP_102243018 624 GQKGQ---YFPAVEgSSee--- 639
WP_124786066 700 KPLPPrfdFFSKHE-SQ----Y 716
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