1M5T,1MB3


Conserved Protein Domain Family
REC_DivK-like
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cd17548: REC_DivK-like 
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phosphoacceptor receiver (REC) domain of DivK and similar proteins
Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.
Links
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Statistics
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PSSM-Id: 381100
Aligned: 35 rows
Threshold Bit Score: 176.191
Created: 9-Nov-2016
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: metal binding site [ion binding site], 3 residue positions
Conserved feature residue pattern:[ED] [ED] [ED]Click to see conserved feature residue pattern help
Evidence:
  • Structure:1MB3: Caulobacter vibrioides DivK binds Mg2+, contacts at 4A
  • Comment:also based on metal binding site of other family members
  • Comment:signal transduction in two-component systems is mediated by metal ion dependent phosphorelay reactions between protein histidine kinases and phosphoaccepting receiver domains in response regulator proteins
  • Comment:for many receivers, Mg2+ is the preferred metal ion, but other divalent ions such as Mn2+ are also used
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             ##                                          #                              
1M5T_A         3 KVLIVEDNELNMKLFHDLLEAQGYETLQTREGLSALSIAREnkPDLILMDIQLPEISgLEVTKWLKEdddlaHIPVVAVT 82  Caulobacter vib...
1MB3_A         3 KVLIVEDNELNMKLFHDLLEAQGYETLQTREGLSALSIAREnkPDLILMDIQLPEISgLEVTKWLKEdddlaHIPVVAVT 82  Caulobacter vib...
GAU09901       5 VVLVVEDDELNLKLVRELLEFSGFETLEATNGLEALAMIRKerPSLVLMDIQMPTMDgLEATRRIKAdaqtrDIPVVALT 84  Desulfoplanes f...
OGO22885       4 KILIVEDNPLNMRLMEMTLRAQNYTLLKAADGQAALEIAQReqPDLIIMDVNLPGMNgLEVTRKIREtpalsRTPIIGIT 83  Chloroflexi bac...
OGP29309       5 KILIVEDNEQNMELFRDLLESHGYVVIEATEGETAINKISQemPDLILMDIQLPKIDgVEITRRVREnpslnNIKIIAIT 84  Deltaproteobact...
KJS14027       5 VILIVEDNIKNLRLVNDIMESQGHQTLQASSGYEGIELARRnkPDLIIMDIQMPDIDgIQVTRILKHeqetsTIPIIALT 84  Peptococcaceae ...
OHC01504       5 NVMVVEDNEKNRKLMRVVLKAKGYNVIEAATGEEALNILKNqkPDIILMDIQLPGIDgITLIKQIKGttnlqDIPIIAVT 84  Planctomycetes ...
WP_082004317   4 RVLIVEDNAMNRELMDYLLRAFGFETLKAVDGRVGLDIARRekPDLILCDIQMPEIDgMEFARLAKAdpalrEVPLVAVT 83  Methylibium sp....
OIO02394       3 KILVVEDNENNTTLVRDILTLHGHEIIEAKNGEEGVKMAREakPDLILMDIQMPVMDgFTAAKALRAdpatkDIKIVGVT 82  Elusimicrobia b...
OGO35737       4 VILIVEDEVTNQKLFRNVLESRGYTVVVADDGRQAVEIALRqrPSLVLMDIGLPGMNgLDVTRCLKGnehtrDIVVVALT 83  Chloroflexi bac...

Feature 1                                           
1M5T_A        83 AFAmkgDEERIREGGCEAYISKPISVVHFLETIKR 117 Caulobacter vibrioides
1MB3_A        83 AFAmkgDEERIREGGCEAYISKPISVVHFLETIKR 117 Caulobacter vibrioides
GAU09901      85 SSAmkgDREAILAAGCDAYMSKPIDIHRLLDLIKA 119 Desulfoplanes formicivorans
OGO22885      84 AYAmkgDKEKVLEAGCDAYLSKPVDTRQLPVIIAE 118 Chloroflexi bacterium RBG_16_51_9
OGP29309      85 AHAmkgDRETFLESGFNDYVSKPIDINSLLQTIAQ 119 Deltaproteobacteria bacterium GWB2_42_7
KJS14027      85 AMAmkgDRETIINAGCDAYLQKPIRFDALIDTVKQ 119 Peptococcaceae bacterium BRH_c8a
OHC01504      85 AYAmkgDEEKIMEAGCDAYVSKPINTQELPLIVEK 119 Planctomycetes bacterium RIFCSPHIGHO2_12_39_6
WP_082004317  84 AFAmvgDRERVLEQGFDGYISKPLEPLSFIEAVNQ 118 Methylibium sp. CF468
OIO02394      83 SYAmkgDKEKVLAAGFDLYIAKPINTRELPAQIKE 117 Elusimicrobia bacterium CG1_02_56_21
OGO35737      84 AYAtkeDQEKALEAGCDGFLAKPIDIVDLVEEVAR 118 Chloroflexi bacterium RBG_16_57_8

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