Conserved Protein Domain Family
CK2S
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pfam15011: CK2S 
Casein Kinase 2 substrate
It is suggested that CK2S (C10orf109) is important in the regulation of cancer cell proliferation. Studies have indicated that CK2S is the downstream target of a protein kinase, casein kinase 2 (CK2), which is upregulated in cancer cells. CK2S has been found to be upregulated in cancer cells. The precise mechanism of CK2 targetting CK2S is not well characterized. It is found to be localized in the nucleus and cytoplasm. This family of proteins is found in eukaryotes. Proteins in this family are typically between 160 and 221 amino acids in length. There is a single completely conserved residue P that may be functionally important.
Links
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Statistics
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PSSM-Id: 464443
Aligned: 29 rows
Threshold Bit Score: 127.785
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_004238440   7 KYQQRFRKVKEEMEKWNELQSRLLSQFNNASSIIQRLQILQDSKNYGAl--------TCVEAIQEAVLLKQMNSLQNILL 78 
XP_006855714   7 KYQQKYKRVRDQMDTWEDLNSRLLSQFGNASSIIERMQVLQNTKYYGVl--------TCVPGMKKELLGKQMESLESFLR 78 
XP_009392317   7 KLQQKYKKAREDMEKWDELQSRLLSLFKSATSIINRLQVLAEAKNYGVl--------RSISGIREALLGKQMETLEMIFR 78 
XP_015613178   7 RVQQRVRKAREEMDRWDDLNSRLLSQFANAAAIVARLPVLEEVKNYGVl--------RCVPNIRENLLGKQMESLEIIFV 78 
XP_004983608   7 KVQQRVRKAREEMDLWDDLNSRLLTNFNRATSVIDRLPVLGEDKNYGAl--------RGVANIQEDLMGKQIESLELIFV 78 
Q6NPG7         7 KWQQKFRKGKEEMEKWEALQVRWVSLFRNASSIIQRLQEMQNHGSYGAl--------RCLKGIEDAVVQQQMGQLESLLR 78  thale cress
XP_009101759   7 KWQQKFRKAKEEMNKWEALQVGWVSRFSKASSIIQRLEAIQNPGSYGAl--------RCVKGIEDALLQKQMDQLETTLL 78 
XP_001418475   7 AFRDAYGALARCRARWDDAQGASVALLGTAVNAFERLPAIHDAARARAvdgseilidDAF---ASRVVEAQYAALDRVFA 83 
EEH56638       8 KYRSLYAKARVVLERWSAAQTRATNLVDSVASIYERLAHLSETSRYGPl-------aDSFPDLPARTRDAQYAALDRVLA 80 
XP_002508830   8 KFRALFVKANDTLGRWTATQSRASALVVSAAMVIERLPELADDQRFGPl-------kERFPTLPQATREAQAVALDRVMT 80 

XP_004238440  79 SMNETMEKFHVVVLSLDKMVRDGRQLIKGGSVQKNVKQLQQHVGMKPSIADCLDGLQLLYEMHQSEYRLKLSVISAISaf 158
XP_006855714  79 AMKTTLNEFDGIVKALEKLWQDGCQLLKGESKQPTARQMQARIGIRPSLSDCLEGLRAIHEMHHSEYLLKSSIIAAISl- 157
XP_009392317  79 SMRETMKEFRGIVLSLEKIARDAWQLVKGGSA-QTSKQMKVQIGLWPNITYCLGGLRSIYEMHQSEYILKLSVVSSLTw- 156
XP_015613178  79 SMRETVEEFNSIARSLHKALRDTNQMVRGGSA-LSAKQMQLQVGILPTIADCLDGLRTLCEMHQAEYALKSSVISSLTw- 156
XP_004983608  79 SMRETLEKFNGIVKALNKALRDTNQMVRGGSA-LTAKQMQLQVGILPTIAECLDGLRTLCEMHQAEFALKSSIISLLTw- 156
Q6NPG7        79 SMKNVMEEFWGCVLTFEKLHRDGLQLRE---IESSKRRVEERIGVKPCITDCLEGLSILYDMHQSEYHLKSSILSVLScl 155 thale cress
XP_009101759  79 SMRNDLEEFRGCVLTFEKLRREGSQLLK---MEQTKRRIEERIGVKPCIADCLKGLSLLYEMHQSEYHLKMSILSALScl 155
XP_001418475  84 RLREECARFDALTRELERAKTDAWTRTRNLKP-PPKRAGGERSGPQPSIADCVLGLEEAWRMHKDECALKREIVKRAs-- 160
EEH56638      81 ALEDELELFDDLANLLDKIQRDGSALVRALRP-PPPFAGALRRAHQPSLAECALGLEDVWRAYHDEATLKRVVCDELVvd 159
XP_002508830  81 NLREEIEYFDELVKELDRLQRNAASLLGGMDP-PPPGGGGLRRGPTPAVAECVLGLRDLWRIHRDELAIKRALVDELTcd 159

XP_004238440 159 alQPSATDDLAA 170
XP_006855714 158 --NSSSADLSAF 167
XP_009392317 157 --KCSPTDAAAF 166
XP_015613178 157 --TSSSSDIAAM 166
XP_004983608 157 --KSSSSDIVVL 166
Q6NPG7       156 ilKPSPGDLNAL 167 thale cress
XP_009101759 156 alKPSPGDLVAL 167
XP_001418475 161 -tCEDAEELKML 171
EEH56638     160 asVEDVKTMAKL 171
XP_002508830 160 alMSDLEEVKAL 171
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