6Z3R


Conserved Protein Domain Family
SMG1

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pfam15785: SMG1 
Serine/threonine-protein kinase smg-1
SMG1 is a family of eukaryotic proteins. In humans this family acts as an mRNA-surveillance protein. In C.elegans, SMG1, a phosphatidylinositol kinase-related protein kinase, is a key regulator of growth. Loss of SMG1 leads to hyperactive responses to injury and subsequent growth that continues out of control. It has an antagonistic role to mTOR signalling in these worms and possibly also in higher eukaryotes.
Statistics
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PSSM-Id: 464869
Aligned: 8 rows
Threshold Bit Score: 802.138
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6Z3R_A        442 MWALSPTVFALLSKNLMIVHSDLAVHFPAIQYAVLYTLYSHCTRHDHFISSSLSssspsLFDGAVI-STVTTATKKHFSI 520 
XP_001963716  557 MYACKPSILELLLTNCRAQDLALWSRYPSTHQAIINLLVVHCQANHNFRTNSSL-----LRDQEQPlSENTSPTANNFAT 631 
EDX17288      581 MYACKPSILELLLTNCRAHELKLWGRYPAAQQAIFSLLVVHCQANHNFRTNSSL-----LRDQELS-AENTSPTANNFAS 654 
XP_002067384  603 MYACKPSILELLIRNCRADDLALWSRYPGTYEAILNLLATHCQANHNFRTTSSL-----LRDGNIQnPEHTSPTAQSFET 677 
XP_001947123  600 MWALQPSIFELLSTKL---DPTIIKMNDPLRFSLMFLLYSHCKKHNNFVASSRLvtagrTSEKSQQnVEINSHKSGNLVK 676 
XP_414907     630 MWALSPTVFALLSKNLMIVHGDIAVHFPAVQYAVLYTLYSHCSRHDHFISSSLSssspsLFDGAVI-STVTTATKKHFSI 708 
EKC30990      623 MWALSPSIFDLASKHFSPLDEVVSEVYPAVQYALLNTLYSHCSRHGNFVSSSSLimqttRLDGSLM-ANVNPTTANNFTQ 701 
XP_009297729  622 MWALSPTVFALLSQNLVIVHSDLAVHHPAVQYAVLYTLYSHCTRHDHFISSSLSssspsLFDGAVI-STVTTATKRHFST 700  zebrafish
6Z3R_A        521 ILNLLGILLKKD-NLNQDTRKLLMTWALeaavlmrKSETYAP-LFSLPSFHKFCKGLLANTLVEDvniCLQACSSLHALS 598 
XP_001963716  632 ILRFLAAVLENAgLLNPQNLRQLLQWLQvl---lnECRDRCDlLLDQEQFLSICRSLVTTACKWS---PQESAACIQIVL 705 
EDX17288      655 ILRFLDSVLGQAhQLTPQNLRVLLQWVEml---lrECREKSDlLMEQENFRGICCNIAATASKLT---PVESAACIQTVL 728 
XP_002067384  678 IIGFLARNLEHSlQLTQQNLKLLLRWTHsl---ldECRERAStLLEQPDFMSICRSVAQIATKWG---LLEAAACIQSVL 751 
XP_001947123  677 ILNIFEKYLKR--NVNVDCKLLVLKWIYell-mhaDSASYLNiILLSPEMINIVRSLIYVALKRNeilLFDGIAQILNIV 753 
XP_414907     709 ILNLLGLLLKKD-NLTQDTRKLLMTWALevavlmkKSETYAP-LFSLPSFHKFCKGLLANTLLEDvniCLQACSSLHALS 786 
EKC30990      702 ILRLLAGLLSQV-HASYDSRCLGLKWIAdi----iGSLQTNPqIFYSEEFTNVIRYITQLGHNSDfqiSMSVCRCLQDVY 776 
XP_009297729  701 LLNLLGMLLSKD-HLNPEARRLLLTWSLevalmmkKSETYAP-LFSLPSFLKFCKGLLANSLNEDttiCLQACNSLQVLS 778  zebrafish
6Z3R_A        599 SSLP------DDLLQRCVDVCRVQLV-HSGTRIRQAFGKLLKSIPLDVVLS-----------------NNKHTEIQEIsl 654 
XP_001963716  706 DYGPekqehlLELLTLYRDMALQQLQ-VLSPNGHTPFSQIYAKLPLRITLTggdtpipgmssrrvcvwQQRMSQCSAV-- 782 
EDX17288      729 DYGLerlakyPQLLILYRDTALQQLQ-MVSTNCHAPYFQIYAQLPLHLTLTgceslmpgmtsrrvsvwQQRISQWSAV-- 805 
XP_002067384  752 GYGLts--qqDPLLLLYRDAALQQIKwILASNQLTVFAQIYAQLPLHVTLFaggvps-----priclwQQKISQCSSV-- 822 
XP_001947123  754 LGNPtfcqskPLIVVDILDLCLSCIN-LTEHDISKQFYALIHKISLITVLQnvsicslknkskfnkkiNQMMSShmrrk- 831 
XP_414907     787 SSLP------DDLLQRCVDVCRVQLV-HSGARVRQTFGKLLKSIPLDVVLS-----------------NRNHTEIQEIsl 842 
EKC30990      777 KINSnl---pINLIQSAVKLSVYKLS-DVRPEVRDGYLSLLRVLPANVTTRlysllhlggdndqsisvQEGAEGVTAAwl 852 
XP_009297729  779 SSLT------MELLQRCVDVCRVQLV-HSAVRVRQAFGKLLRSVPMHVALS-----------------AHSHSEIKEIsl 834  zebrafish
6Z3R_A        655 alrshmskapsntfHPQDFSDVISFILYGNs-hRTGKDNWLERLFYSCqrldkRD---------QSTIPRNLLKTDAVLW 724 
XP_001963716  783 --------------RDSVFRDFFERLQHPE---QQPLTNSLRDLFVRScqvapQDe-------rQEKLSQCTRRCQRLAT 838 
EDX17288      806 --------------RDTVFRDFFERVQKPE---QESLVHCLRELFVRScqvapQDe-------rQMNLSQCTKRCQRLAT 861 
XP_002067384  823 --------------RDTVFREFFEHLQQSE---QQQLNQSLRDLFVRScqisaMDe-------rQEMLSHCIRRCQRLAA 878 
XP_001947123  832 ---------avvtlKTEYFKNYMCEMIEPNtnnNDSTTHWLLDVVNSCsfdidSGe---------tELLSHAQHCRVFLY 893 
XP_414907     843 airshmskapsntfHPQDFSDVISFILYGSt-hRTGKDNWLERLFYSCqrldkRDq---------pTIPRNLLKTDAVLW 912 
EKC30990      853 arrahinripngefHAVNFRQIMAYILHDTspiQSGSWNWLEAMFYSC-----QDathdhkmieTFRMSNFVDNNEAMLW 927 
XP_009297729  835 airrhmskvpsntfHPQDFSDLIGFILYGTv-hRGGKEPWLERLYHSCqrlekKDs---------aMVPRALLKTEAVLW 904  zebrafish
6Z3R_A        725 QWAIWEAAQFTVLSKLRTPLGRAQDTFQTIEGIIRSLAAHTLNPDQDVSQWT-T----ADNDEGHGNNQLRLVLLLQYLE 799 
XP_001963716  839 AWMQFEAARYCVDQRLRTTLGKPQETFLGFEAIIMRHARQLSGCGKEEERAAlD----TLTLEELSNMQSNLVLMLGFLD 914 
EDX17288      862 AWLQFEAARYCVEQRLRTTLGKPQDTFFGFEAIIMRHARLLSGCAKEMERSAmD----TLSLEELLNMQSNLSLLLGFLD 937 
XP_002067384  879 AWMQFEAARYCVDQKLRTTLGKPQDTFLGFEAIIMRHARMLSGCAKEAERIDpD----GLSLMQLSNMQMNLNMLLGFLD 954 
XP_001947123  894 FWINWEAANFCVINRLRTPFGKPNSTFRAIEGGIKMWARD--------SISAlNdetkVKHTEGKLNNLRYTRNLVAFIE 965 
XP_414907     913 QWAVWEAAQFTVLSKLRTPLGRAQDTFQTIEGIIRSLAAHTLNPDQDVSQWTt-----ADNDEGHSSNQLRLVLLLQYLE 987 
EKC30990      928 FWATWESAQYCVLNRLRTPLGKPQETFTSIEGVLKMFAKELDKPAEERNDISkTdqkkGGAKSSDLSSHLRVHLLLQFME 1007
XP_009297729  905 QWAVWEAAQFTVLSKLRTPLGRAQDTFQTIEGMIRSLAAHSLNTEQELSQWSg-----GESDEGHHTNQLRLALLLQFLE 979  zebrafish
6Z3R_A        800 NLEKLMYNAYEGCANALTSPPKVIRTFFYTNRQTCQDWLTRIRLSIMRVGLLAGQPAVTVRHGFDLLTem-ktTSLSQGN 878 
XP_001963716  915 ALEKLIYNAAEGSAFALRPPEKPVAAFFRLNNPTCQSWFNRIRIGVVIIAVHVQQPELVIRYAQKILL-----TQKAQDA 989 
EDX17288      938 VLEKLIYNAAEGSAFALRPPPKPVAAFFRLNNPTCQSWFNRIRIGVVIIAMHVQQPELVIRYAQQILV-----NPQTQDP 1012
XP_002067384  955 ALEKLIYNAAEGTAFALRAPEKPVSAFFRLNNPTCQSWFNRIRIGVVIIAMHSQQPELVIRYAQQILV-----TQNPQDC 1029
XP_001947123  966 CLEKSVCNAIDGTATALPTAQKPVRHFFHTNRNTCYEWNSTIRSAMLAVALNSGLSSSAIRHGQYLVHhl-tkQSEFPVK 1044
XP_414907     988 NLEKLMYNAYEGCANALTSPPKVIRTFFYTNRQTCQDWLTRIRLSIMRVGLLAGQPAVTVRHGFDLLTemktnNSLSQGN 1067
EKC30990     1008 HLEKLLYNAYEGCAVSMPMSPKTVRTFFRTNKGTCLEWLSRVRSSVIKIALHSGMPAMAIRQCHQLLQem-kdNNTLQGY 1086
XP_009297729  980 NLEKLMYNAYEGCASALTAPPKGIRTFFYTNRQTCQDWLTRIRLALMRVGLLSGQPAVTVRHGFDLLTei--kNSSTQGP 1057 zebrafish
6Z3R_A        879 ELEVTIMMVVEALCELHCPEAIQGIAVWSSSIVG-KNLLWINSVAQQAEGRFEKASVEYQEHLCAMTGVDCCISSFDKSv 957 
XP_001963716  990 TYSQAIVYLAWAWVCCQESDSLRGLYLWARSKSS-KSFQWLQCAADQAGGRKDAALAGYRSLLNETEEQPPELDTHTRQ- 1067
EDX17288     1013 TYSQAIVYMAWALISCQESDSLRGLRLWASSKSS-KSYKWLKYAADQAAGKRESALAGYKTILAEKEQQ-SELEPHTRQ- 1089
XP_002067384 1030 SFSQAIVYLAWAWICCQEADSLRGLYLWARCKVSgKTFQWLHCAADQAAGRKETALSGYSQILAEDD---AELEPHTRQ- 1105
XP_001947123 1045 EFILAIIQLAWAYSKLKESDCIRGLYVWSKEVAH-LKLPFLNILADQASGKFEEAAESYMNLLTTnsdqiiiylkgggg- 1122
XP_414907    1068 ELEVTIMMLVEALCELHCPEAIQGIAVWSSAVVG-KSLTWINSVAQQAEGRFEKATAEYQEHLCAMTGVDCCISGFDKTv 1146
EKC30990     1087 DFEQTVLFLVKALVELKEGDAIMGVYNWCKEQTG-KKFLWIKALVEKATGKYESAAKELKNVLKVMVSSDSEKADSPRDd 1165
XP_009297729 1058 EMEVPVTMLVEALCELRCPEAIQGLAAWSLANTG-KSMGWLSSVALQAEGKFEKAALEYQEQLCAVTGMDCSIKVFDRSl 1136 zebrafish
6Z3R_A        958 ltlanagrnsaspkhslng-esrktvlskptdsspevinYLGNKACECYISIADWAAVQEWQNSIHDLKKS--TSSTSLN 1034
XP_001963716 1068 ---------------------------------------FVVAQMMQCLQDTGQWSQLVELKQRQLTRPED--SERNPFL 1106
EDX17288     1090 ---------------------------------------FVVAQMMQCLQDLGQWSQLVELKQQHMMRPED--RELNPFL 1128
XP_002067384 1106 ---------------------------------------FVIAQKMQCLQDLGRWSRLVELKQKHLNRPED--SELNPFL 1144
XP_001947123 1123 -------------------------sinniegplevlqkFIIEQLKECYMSICDWKPLMDWSQNEENLIPSi-AKDKYFW 1176
XP_414907    1147 lklansnsvnnaspkhslngetrktvltkpsdcspevinYLGNKACECYISIADWSAVQEWQNMVHDLKKS--TSNTSIN 1224
EKC30990     1166 lskvemimpkkitgils----kqspfpppdsnipvlkvhFVVTEIFDCYEKLYDWESVMEWQENVLQYRQDysHLQAAFN 1241
XP_009297729 1137 lkltgtntsspkhtssge---grktvllkssecspevlnFLANKACECYVALSDWESVQEWQASMMNLKKN--SSSSSVN 1211 zebrafish
6Z3R_A       1035 LKADF---NYIKSLSSFESGKF 1053
XP_001963716 1107 QQSNVevsALERLLAKSEEQSA 1128
EDX17288     1129 QRSNVevnALERLLARGQEACS 1150
XP_002067384 1145 QRSNVevsALEKLLAKSEELSS 1166
XP_001947123 1177 QNRYVs-aNDLQIVNDVEEGny 1197
XP_414907    1225 LKADF---NYIKSLSSFESGEL 1243
EKC30990     1242 SDVDL---NYIRALSAFEDGDF 1260
XP_009297729 1212 LKTDF---NYIRAMSRFEEGDF 1230 zebrafish
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