3A43,2KDX


Conserved Protein Domain Family
HypA
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pfam01155: HypA 
Hydrogenase/urease nickel incorporation, metallochaperone, hypA
HypA is a metallochaperone that binds nickel to bring it safely to its target. The targets for Hypa are the nickel-containing enzymes [Ni,Fe]-hydrogenase and urease. The nickel coordinates with four nitrogens within the protein. The four conserved cysteines towards the C-terminus bind one zinc moiety probably to stabilize the protein fold.
Links
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Statistics
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PSSM-Id: 460085
Aligned: 405 rows
Threshold Bit Score: 52.5242
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3A43_B              2 HEWALADAIVRtVLDYAqREgAS--RVKAVRVVLGELQDVAEDIVKFAMEQLFAGt--IAeGAEIEFVEEEAVFKCRNCN 77  Thermococc...
Q31DZ4              2 HEYSIVQALIEqCETLA-QT-NQafQVSKVSVKVGLLSGVEPYLLQTAFEAFKKTsdvCQ-QAELDMKIQAVEVFCLCCG 78  Hydrogenov...
WP_013505503        2 HEFSLIQNLLQqCEYHA-EQ-AGshKVLAIHVSIGMMAGVEPELFKRAYDTFRQQt-vCS-DAELEIHWQPLELFCLQCA 77  Desulfuris...
jgi:Sama_1669       2 HEFSIVQALLDsCEQHA-RS-VGatGISRVSIRIGALSGVEPALLATAFDTFKLDg-rCA-NASLDMEIEPLRLDCNECG 77 
Q8EF96              2 HEYSIVSALIEqCEQYA-KA-NQatKVTRVEIKLGVMSGVEPALLQTAFETFKLDg-iCR-EAKLCMTLQPLVIKCADCQ 77  Shewanella...
Q081V6              2 HEYSIVMSLMEqCEALA-QL-HKatRIEQVELKIGVLSGVEPALLSKAFETFKLDs-vCH-EARLVINVQPLVLQCNHCE 77  Shewanella...
jgi:HY04AAS1_0047   2 HEFSVVQALLMqVEDIA-KE-HNanSVEKIYVVIGEVSGVEPHLLKMAFDTFKENt-iAS-KADLVIEFQKPHIYCEECK 77 
WP_013909268        2 HEYFIVQNILKtVEDVL-KD-YPgkKVTKAVLLIGKFSGVEPDLLKTALDFFKKGs-pLE-EAEIIIELEDLKIKCLDCG 77  Thermodesu...
O67133              2 HEFSIVQSLLTlIEDYA-RE-NNakSVTKVVVSIGVLSGVEPHLLEMAFNTFKEGt-vAE-KAELIMEIEKLKIKCMDCG 77  Aquifex ae...
WP_012963645        2 HEFSVVQSLMElIERYA-QE-NNarKVTKVVLSIGVLSGIEPHLLELAFNTFKEGt-iAE-EASLVVEIEKLKIRCQECG 77  Hydrogenob...

3A43_B             78 YEWKlKEVkdKfdeRIkedihfipevvhaflACPKCGSHDFEVVKGRGVYVAGIK 132 Thermococcus kodakarensis KOD1
Q31DZ4             79 ETNQ-LSEh----hYV----------------CPACQGDRVTVTDGKEMFLMQLE 112 Hydrogenovibrio crunogenus XCL-2
WP_013505503       78 SLTS-LHEp----rYS----------------CQQCGSTSVRVEKGEDILLMRLE 111 Desulfurispirillum indicum
jgi:Sama_1669      78 YQGE-ADGhrV--------------------LCPKCQSPFTRVIGGEDMLLLQLE 111
Q8EF96             78 QESV-LDErsI--------------------VCPACNSYHTRVLDGEEMLLMQLE 111 Shewanella oneidensis MR-1
Q081V6             78 QQSQ-VDErtI--------------------VCPICQSNKTTVIDGEDMMLMQLV 111 Shewanella frigidimarina NCIMB 400
jgi:HY04AAS1_0047  78 KEFS-LERysM--------------------RCPLCGSFKVRLTKGDELILKTLE 111
WP_013909268       78 KTSV-KERw----dII----------------CPFCKSFNTQIISGEEMFLKTLE 111 Thermodesulfobacterium geofontis
O67133             78 KESE-KEElnM--------------------LCPGCGSLNTQIISGQDMFLKSLE 111 Aquifex aeolicus VF5
WP_012963645       78 RESE-KEElnL--------------------LCPLCGSLSAQIVAGQDMLLKSLE 111 Hydrogenobacter thermophilus
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