2M3V,4R0T,1YWF


Conserved Protein Domain Family
TpbA-like
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cd14529: TpbA-like 
bacterial protein tyrosine and dual-specificity phosphatases related to Pseudomonas aeruginosa TpbA
This subfamily contains bacterial protein tyrosine phosphatases (PTPs) and dual-specificity phosphatases (DUSPs) related to Pseudomonas aeruginosa TpbA, a DUSP that negatively regulates biofilm formation by converting extracellular quorum sensing signals and to Mycobacterium tuberculosis PtpB, a PTP virulence factor that attenuates host immune defenses by interfering with signal transduction pathways in macrophages. PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides, while DUSPs function as protein-serine/threonine phosphatases (EC 3.1.3.16) and PTPs.
Links
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Statistics
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PSSM-Id: 350378
Aligned: 24 rows
Threshold Bit Score: 119.401
Created: 26-Oct-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic site
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 7 residue positions
Conserved feature residue pattern:C x x x x x RClick to see conserved feature residue pattern help
Evidence:
  • Structure:4R0T: Pseudomonas aeruginosa TpbA binds phosphate ion in the active site; contacts at 4A
  • Comment:also based on structures of cys-based phosphatase superfamily members with bound substrates (both peptide and non-peptide)
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
2M3V_A     19 DPSINLYRMSP-------------TLYRSALPn---aQSVALLQRLQVKTVVSFIKdddra----------wlgqaPVRV 72  Pseudomonas aerugi...
4R0T_B     44 DPSINLYRMSP-------------TLYRSALPn---aQSVALLQRLQVKTVVSFIKdddra----------wlgqaPVRV 97  Pseudomonas aerugi...
1YWF_A     27 PGAWNFRDVADtata-----lrpgRLFRSSELsrlddAGRATLRRLGITDVADLRSsrevarr------gpgrvpdGIDV 95  Mycobacterium tube...
NP_295635  13 DGALNFRRPLP-------------GLWRSANLsflseRGRAELLTLGLGRIIDLRDrrerlvd-------appllgQAEY 72  Deinococcus radiod...
Q05918     55 APGMCARSPACrata-----ipadAFVRTADLgrltdADRDALAALGVKLDIDLRTadeeaqsp-----dllarddRFDY 124 Nostoc commune
YP_884517  12 GGAWNFRDVAQetgi------rpgVLYRSSELsklsdDGRAVFKRLGITDVADLRShqevqrr------gpgqvpdGVAV 79  Mycobacterium smeg...
NP_812216 111 PGIQNFRDLGGyksaetgkdtrwgMLYRSAQIdsipfCSRRELKNMGIRTIIDLRSeeerhny-------pqlhdeDFNV 183 Bacteroides thetai...
NP_770805  12 QGASNFRDLGGyptidg-rttrwrHIFRSNHLgqltaDDIEIVRALGVRSAFDFRGleeraa--------gvcvvnEITV 82  Bradyrhizobium
NP_421749   8 QGVENFRDFGDyaagag--rlkkgVLFRAAHQaeatdEDLAHLASLGIATLVDLRRpnerers-------psrrwdGFSA 78  Caulobacter vibrio...
AMV26136   30 THMRNFRVVEDg------------VLYRSGQLtp--kGMDRVLSDYNIKTVVTLRVarqpgakspdaweedvcaarGLNH 95  Gemmata sp. SH-PL17

Feature 1                                                                                     
2M3V_A     73 VSLPTHadr-------------------------------------------------vdDAEVLSVLRQLQAAERe-gP 102 Pseudomonas aerugi...
4R0T_B     98 LSLPTHadr-------------------------------------------------vdDAEVLSVLRQLQAAERe-gP 127 Pseudomonas aerugi...
1YWF_A     96 HLLPFPdladddaddsaphetafkrlltndgsngesgessqsindaatrymtdeyrqfptRNGAQRALHRVVTLLAagrP 175 Mycobacterium tube...
NP_295635  73 LNLPLLpwrvramneatav----------------------------artnadlyrthldHAANSIVTILGAVLDAppgA 124 Deinococcus radiod...
Q05918    125 QRISLMgtekmdlqkmmtsf---------------------------pdslgeayvqwlgHSQPQFKQVFQRIAAQqdgA 177 Nostoc commune
YP_884517  80 HLLPFHpddtsgqdaphestfqrvmsesp---------dgedvtesarrymtevyeefptLPGAHNAVRQVVSLLAagrP 150 Mycobacterium smeg...
NP_812216 184 LHLPIAtgnmehilqdirdkkie--------------------tdtiyrlvermnrqlvtNYRKEYKELFTLLLDRnnyP 243 Bacteroides thetai...
NP_770805  83 HSLPIEptvvaalraelargtlt---------------------apvalelmresyrnyvRYNTHSFRALFGHLLEdraP 141 Bradyrhizobium
NP_421749  79 TVIDNDlgmtgedpwhtflkesdls-----------------lesihdymdeyyrrapfkERHLDLFSRYFQAVAKgqgA 141 Caulobacter vibrio...
AMV26136   96 VRIVPRvwgade------------------------------------------dgeipaEQAVQEFLAVVDKKENh--P 131 Gemmata sp. SH-PL17

Feature 1         #######                                                                     
2M3V_A    103 VLMHCKHGNNRTGLFAAMYRIVVqgwdKQAALEEMQRGgfgde------------------------------------- 145 Pseudomonas aerugi...
4R0T_B    128 VLMHSKHGNNRTGLFAAMYRIVVqgwdKQAALEEMQHGgfgde------------------------------------- 170 Pseudomonas aerugi...
1YWF_A    176 VLTHCFAGKDRTGFVVALVLEAVgl-dRDVIVADYLRSndsvpqlrarisemiqqrfdtel------------apevvtf 242 Mycobacterium tube...
NP_295635 125 VLIHCHAGKDRTGLITALCGELAgl-tQEQIAEDYAQTgeeltdfyaarrkhktpeqwaalep-------fshtrtedil 196 Deinococcus radiod...
Q05918    178 VLFHCTAGKDRTGIIAGLLLDLAgv-pKAEIVHNYAISahylegqpkdsderadhgagqaepgdrpqdgghgryragqhg 256 Nostoc commune
YP_884517 151 VIAHCFAGKDRTGFTVATVLDAAgv-dRDDIFADFLRSneaitplrnrimdsvrarsgde--------------peiitf 215 Mycobacterium smeg...
NP_812216 244 VVIHCTSGKGRTGIVSALVLAALgv-nEEAIMKDYRLSndyfnipkasryayklp------------------------i 298 Bacteroides thetai...
NP_770805 142 LVIHCTAGKDRTGFASALILHALgv-sDDVIAEDYLLTnrhyrrdasnasdl---------------------------- 192 Bradyrhizobium
NP_421749 142 VLIHCAAGKDRTGILAALTHHIAgv-sDDDVIDDYLLTndptrferrghiflnniyel------------------tgkr 202 Caulobacter vibrio...
AMV26136  132 ILVHCFAGIHRTGTMCAIFRMEYhkwsPERAMSEMQLYgfapedm----------------------------------- 176 Gemmata sp. SH-PL17

Feature 1                            
2M3V_A    146 -----------ddmrDASAYVRG 157 Pseudomonas aeruginosa UCBPP-PA14
4R0T_B    171 -----------ddmrDASAYVRG 182 Pseudomonas aeruginosa PAO1
1YWF_A    243 tkarlsdgvlgvraeYLAAARQT 265 Mycobacterium tuberculosis
NP_295635 197 aalghldeqwggvgaYLAAYGFS 219 Deinococcus radiodurans R1
Q05918    257 avlaalhsqyggaegYLKSIGVS 279 Nostoc commune
YP_884517 216 aearltdevlgvreeYLAAAWKR 238 Mycobacterium smegmatis
NP_812216 299 nsqeaittiysakedFLNAAKEQ 321 Bacteroides thetaiotaomicron
NP_770805 193 -padvldaigsveasYLAAAFEA 214 Bradyrhizobium
NP_421749 203 pteaamraamgvearYLAAAFAA 225 Caulobacter vibrioides
AMV26136  177 ---------hqhiagYLREYKPR 190 Gemmata sp. SH-PL17

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