5T9P


Conserved Protein Domain Family
RRM_NIFK_like

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cd12307: RRM_NIFK_like 
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RNA recognition motif in nucleolar protein interacting with the FHA domain of pKI-67 (NIFK) and similar proteins
This subgroup corresponds to the RRM of NIFK and Nop15p. NIFK, also termed MKI67 FHA domain-interacting nucleolar phosphoprotein, or nucleolar phosphoprotein Nopp34, is a putative RNA-binding protein interacting with the forkhead associated (FHA) domain of pKi-67 antigen in a mitosis-specific and phosphorylation-dependent manner. It is nucleolar in interphase but associates with condensed mitotic chromosomes. This family also includes Saccharomyces cerevisiae YNL110C gene encoding ribosome biogenesis protein 15 (Nop15p), also termed nucleolar protein 15. Both, NIFK and Nop15p, contain an RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain).
Statistics
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PSSM-Id: 409748
Aligned: 34 rows
Threshold Bit Score: 93.7922
Created: 13-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5T9P_B        12 IIYVSRLPhGFHEKELSKYFAQFGdLKEVRLARNKKtgnSRHYGFLEFVnkEDAMIAQESMNNYLLMGHLLQVR 85  Saccharomyces cerevis...
17554894      33 VVKIKRIPfGFFEKELLGYFRQFGnVLRIRVARNRRtgnHKGWAYVGFDnkAVAEIAAESMNGYLMFEQRLGCT 106 Caenorhabditis elegans
AAM18872      42 AVFVGHIPhGFFEPQVKRFFSQFGtVSRVRLARSKKtggPKGYGYIEFEceEVAKVVAETMNNYLMFEKLLKCE 115 Florida lancelet
NP_651066     52 VVIVKHLPhGFFEQQLRQYFRQFGrVLRVRLARSLRtgnSKGYAFVEFEypEVAKVAADTMDNYLMFQKVVKAT 125 fruit fly
EFA75866     352 IIYIGHLPhGFFEKELTKYFSQFGnVTNVKVARNPKtkkSKHYAFVKFDdkEVAKIAAESMDGYIMFKKKLICK 425 Polysphondylium palli...
EES98966      10 VIYVGHLPhCFMERPMRNFFSQFGkVLQVRVSRNKEq-kSRGYGYVKFAsrAVAKIAAETMDNYLMFNKILKVS 82  Giardia intestinalis ...
XP_002676818 133 TFVIRKLPhGFYEEEVTKFFSQVGtVINVRVPRSKNtghPLNKAYVQMEdpEIAKMIVETFDYYLLNDRVIRVS 206 Naegleria gruberi str...
XP_650506     22 IVRIYNLPkILDERDLRRYFSQYG-ELKGLAIKKTDygvSKGTCVVKFAdcVVARIVAETLNNHILENRLLRTE 94  Entamoeba histolytica...
EFW19907     227 TVYIGRIPhGFYEHEMRAYFSQFGdITRLRMSRNRTtgrSKHYGYIEFAseSVAKIVADTMDNYLMFGHILKCK 300 Coccidioides posadasi...
ABK23784      53 VLYIGHIPhGFFEDQMRGFFSQFGaIKRLRISRNRKtgkSKHYGFIEFEspAVAEIVADCMHNYLLFEHILKVQ 126 Sitka spruce
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