Conserved Protein Domain Family
LYRIC

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pfam15686: LYRIC 
Lysine-rich CEACAM1 co-isolated protein family
LYRIC is a family of proteins found in eukaryotes. It is a type-1b membrane protein with a single transmembrane domain and localizes to the endoplasmic reticulum and the nuclear envelope. It is also found in the nucleolus, suggesting functional relationships between these two cellular compartments. It is found to be colocalized with tight junction proteins ZO-1 and occludin in polarised epithelial cells, suggesting that LYRIC is part of the tight junction complex. LYRIC has been shown to promote tumour cell migration and invasion by activating the transcription factor NF-kappaB.
Statistics
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PSSM-Id: 434858
Aligned: 11 rows
Threshold Bit Score: 338.041
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_012427396   6 WQEAAARWAEEAAARVRDALSGGLGLLRAELGLEL--GLDPQALPAWLALAvPAALGFVLLGLL---LAAAC--GGGLRK 78 
6_pfamImport   1 FQVFTLEKAEQLSGRLREVLSGGQAYILARFGVDM--GLEPDLYSAWIVLS-ATALVLLLLLAVs--WAAVR--GGPLLG 73 
Q9Z1W6         6 WQDELAQQAEEGSARLRELLSVGLGFLRTELGLDL--GLEPKRYPSWVILVgTGALGLLLLFLLgygWAAAC--AGARKK 81  Norway rat
1_pfamImport   1 LRGAALEKAELLSGHLKELVSTGQQYVRDRFGVDL--GLNPDVYPTWVILS-TATVGLLLLLRLs--WAAAC--GGRFAG 73 
XP_017207032   5 WQEIASQHVEQITGYVRESLSTGLVYLKSELGIDL--GLNPDLCAPWLLLL-TAWAGLVLLLVL---WVSVC--RG-FSK 75 
5_pfamImport   1 WQEAASEQFNLLTKRLNELLSKGLGLLRSELGVDL--GLKPELIPPWVILL-AACTGLVLMVAL---WASTC--RSLFKK 72 
XP_005464971   4 WQDAAARQVILLTDRVNELLSRGLELLRSELGVDF--GLKPELIPPWMILL-LAGTGLLLMVAL---WASVC--RGLFKK 75 
7_pfamImport   1 WQDAASQQVKLLTNRLNELLSKSLGLLRSELGVDL--GLKPELIPPWVILL-AACTGLVLMVVL---WASVC--RAIFKK 72 
XP_006001076   5 WQDAAAQQAEVVSARLRELMSSGLGLLRTELGLDL--GLDPERYPSWAILL-VAVLGLLVVGLV---WAATC--AGr--- 73  coelacanth
XP_008106595   7 WPESVARQAEEVSARLREVLSAGAGLLRTELGLELppALEPQRLPGWLLLLaTSLLPLLLLLVLl--WGLRCgrGGSARP 84  green anole
XP_027705738   9 WLDALAQQAEEGSAPLRELLSAGLYLLRTELGLDL--GLEPHSYPAWVILLgTAALGLLLLLLLglgWAAAC--SGARQR 84  common wombat
XP_012427396  79 KparSAAVRKGDEAVGagltagggpgkaAGP-----------------------------GPGQLNL-KGDEQKKRNRKK 128
6_pfamImport  74 K---TPTTRVDPRSCV------------PDK-----------------------------AGPAKPV-GAEEPKKRNKKK 108
Q9Z1W6        82 r---RSPPRKREEVTPpt--------paPED-----------------------------PAQLKNL-RSEEQKKKNRKK 120 Norway rat
1_pfamImport  74 KkrgSPDPRGAGE-----------------------------------------------PGKAQTP-KPEEQKKRNKKK 105
XP_017207032  76 RlagTETGDSAEN-----------------------------------------------TGPAQPVkKADEPKRRNRKK 108
5_pfamImport  73 RpaeNAADDGIAEK----------------------------------------------RDSGKPV-KSEEPKKK-KKK 104
XP_005464971  76 RpvmSHADDGIELK----------------------------------------------RTVGKPV-KSEEPKKK--KK 106
7_pfamImport  73 RgavRPEDDGIEIK----------------------------------------------RTVSKPI-KSEEPKKK-KKK 104
XP_006001076  74 ----KGAGREKEPLSSsva------avsSSR-----------------------------APAGKNQ-KIDDQKKKAKKK 113 coelacanth
XP_008106595  85 RrlrRTTAEEEEEDEDe-----------EEDddeeeeaaatpkaglarggggphkgppltGPAGLLL-KADEQKKRNKKK 152 green anole
XP_027705738  85 Rr--SPPRRREE--VPapa-------paPED-----------------------------GALLKSL-RSEDSRKKNRKR 123 common wombat
XP_012427396 129 LPER--AArpngr-sfidVSEDEVIQTVRKDN-IKQP----------------------------------------VDT 164
6_pfamImport 109 TAEKvqTA----------SASYDVTVAQSKQT-PNASisilslglhaqtmaaaavpltvgssatlsaaisakqpvnlTPP 177
Q9Z1W6       121 LPEK---Pkpng--rtveIPEDEVVRTPRSIT-AKQP----------------------------------------PET 154 Norway rat
1_pfamImport 106 PLDK--NTqsngq-pvaaAQ-DAVKVKATVVV-PK------------------------------------------PAP 138
XP_017207032 109 NAEK--KAqrng--lavePQ-EEVKTADDQEL-----------------------------------------------A 136
5_pfamImport 105 STEK--KAqpngr-aaaePQ-EEAIAAEETVPhQQQQ----------------------------------------PAA 140
XP_005464971 107 KAEK--KSqpngr-aiaePQ-EEAIASEEIVP-HHQP----------------------------------------PPP 141
7_pfamImport 105 VFVWnqKTqsngr-avaePQ-EEAIVSEELVP-HHQP----------------------------------------PPS 141
XP_006001076 114 SAEK---Gkpngr-taveLPEEEAVPVLLKET-LKQP----------------------------------------LET 148 coelacanth
XP_008106595 153 APEK---AgrlngqpaheISEEEITPTVRREN-LKQP----------------------------------------SDV 188 green anole
XP_027705738 124 VAEK---Pkpngr-tvpqVPEEEVITSPRREA-AKQQqqpqpqq--------------------------qqqqqqqLDA 172 common wombat
XP_012427396 165 EKKNEKS------------------------------------KKKKKSKG----DSKTVQDSSRLDGKEVDE------- 197
6_pfamImport 178 VLKPKKDkteqq--------------------------pvqakKTKKKVKI----DVKPAQPVTTNDWKEPDEgq----- 222
Q9Z1W6       155 DKKNEKSk-----------------------------------KNKKKSKS----DAKAVQNSSRHDGKEVDE------- 188 Norway rat
1_pfamImport 139 QVKTQKVpevqa--------------------------avqvmKNKKKTKTivkpAVKPAQLVSTNDGKETDDa------ 186
XP_017207032 137 EVRADKGk-----------------------------------KNKKKTKA----SAKEKKSSTSVDGKEPDEavgnmsv 177
5_pfamImport 141 EGKAEKAseitisrvhsdvnpllksplsprcpctmepeqlplkKSKKKAKQ----PVKETKTGTA-TGKEPEE------- 208
XP_005464971 142 EVKPEKVae--------------------------------vkKSKKKAKQ----AVKETKTVTT-DGKEPEE------- 177
7_pfamImport 142 EVKLEKIpe--------------------------------akKSKKKAKQ----AAKETKPAAG-DGKEPEEeiphsa- 183
XP_006001076 149 EKKTEKSk-----------------------------------GKKKKPKA----EAKQVHDVSALEGKEFEE------- 182 coelacanth
XP_008106595 189 EKKTEKSk-----------------------------------KNKKKQRG----DAKTVQDQSRADGKEADE------- 222 green anole
XP_027705738 173 EKKNEKLk-----------------------------------KNKKKSKS----EVKAVQNSSRHDGKEVDE------- 206 common wombat
XP_012427396 198 -----GAWETKISNREKRqQRKRDKVLND----GGSgesnlqgiENTVTVPIEQLMPTPSlpvgLRKNKGDall-----n 263
6_pfamImport 223 ----aGTWETKVSNREKK-KRRKDKISEDsc-gPGG--------PEAPKAQVETPVVTAT----AKKNRGN--------- 275
Q9Z1W6       189 -----GAWETKISHREKRqQRKRDKVLTD----SGSldstipgiENTITVTTEQLT-TASfpvgSKKNKGDshlnvqvsn 258 Norway rat
1_pfamImport 187 -----GNWETKVSNREKKqQRRKDRGPEDsg-sPGG--------LQAPKGNVET--PAATarvnTKKNRGNtgikaskfn 250
XP_017207032 178 mvnlaGTWETKVSNREKRqQRRKDKAPDDesgsPVPsaa--sgaTEQLQTTLEEAETTITsavsTPPVQrvv-------e 248
5_pfamImport 209 -----GTWETKVSNKEKReQRKKEKGSSDgsasPGGgdar-aspPEQPKASVAPTP--AS----QKKKKGE--------- 267
XP_005464971 178 -----GTWETKVSNKEKReQRKKDKSSSDgsasPGGggtpvsvpTEQPKASTAPAS--TN----QKKKKGE--------- 237
7_pfamImport 184 qwsfsGTWETKVSNKEKReQRKKDKSSSDgsasPGGgdtpvstpPEQPKTTAAPAP--TN----QKKKK----------- 246
XP_006001076 183 -----GAWETKVSNREKR-QRKRDKVLND----VGSgdanlhgtDATTVASAEQPTAMATvsivPRKTKGEpvhtnqltg 252 coelacanth
XP_008106595 223 -----GAWETKISNREKRqQRKRDKVLTD----TGPesni-samENSVSLSTEPLTSSASfsvgPRKNKGDtvlnvqvnn 292 green anole
XP_027705738 207 -----GAWETKVSNREKRqQRKRDKVQPD----TGPldpavsgiESAYTVTTEQLI-TASfpvgSRKNKGDsllsvqgsn 276 common wombat
XP_012427396 264 aqINSSKPA-K-GESSIPQV----SPGLSESHTV----NGGSWNEKSVKISSQIGVGEE-KWTsVPSTAAGKRKTEtlaW 332
6_pfamImport 276 --NVLSQNQ-G-PQLSAPSA----SPSRRGEPSVvdddDGGGWTSVSAKKTEQKGSGRKpVHA-APQPSVPQKQQS---W 343
Q9Z1W6       259 fkSGKGDST-L-Q------V----SSGLNENITV----NGGGWSEKSVKLSSQLSAGEE-KWNsVPPASAGKRKTEqsaW 321 Norway rat
1_pfamImport 251 srT-----------LCTCTV----SSARREEPSV----NGGGWTDASRQTG-----------SgVPAATHYRAAPRpqtW 300
XP_017207032 249 vdPPEIEATfV-QDPVIPQV----TPCWEEVLTV----NGSGWSDLGLQLPSHMTSVQTeSWTsMTVPTE-RQTSEpsvW 318
5_pfamImport 268 --TAKVKSE-K-IEVVAPQV------TSREVV-------AATVTEKALKAP----APKAgPWT--------TASEPallW 318
XP_005464971 238 --STKVKPE-K-VEAVVSKV------NSNNAVEV-----SSAVPDVPVKIPAQTVAPKTaSCT---------TSREpplW 293
7_pfamImport 247 --------E-C-YITIVPQPpqatSLKDLKVAAV-----SACITEVPVKVPTHKISGKSePWK--------ANREes-lW 302
XP_006001076 253 vkSGTGDSV-S-Q-------------GWIEAPDV----NGGAWTDVPMKIPSQISGGEEkKWTpMQATSAANRNQEtttW 313 coelacanth
XP_008106595 293 skSGKGDTT-LqQ------V----PSGLNEGPTV----NGGNWNEKPVKISPQINTSEE-KWTpV-SSAGGKRKNEtsaW 355 green anole
XP_027705738 277 fkSGKGDLT-L-Q-------------GLNENPTV----NGGSWNEKSIKIPSQISAa---SCS----GNVDRRVNN---- 326 common wombat
XP_012427396 333 GQDTGDAngngkdwgvslvgrpwkerslftpIAAW-NVDaRINTSEQNSASFSSFGLtpgv------------------- 392
6_pfamImport 344 TQETQAA------------------------AAGRsSTD-ARGKTGPKTVSFSVLGC----------------------- 375
Q9Z1W6       322 TQDPGDTna---------------------nGKDW-----GRNWSDRSI--FSGIGS----------------------- 350 Norway rat
1_pfamImport 301 GQETPGTtsgqnq------------pvtqrnRRTWsGID-GRKKADINPVTFSMLGP----------------------- 344
XP_017207032 319 PQDMEG---------------------------SWtIVDrPNI-----PVTFSGL------------------------- 341
5_pfamImport 319 RPDVDE---------------------------SWtVIErGMATT--SPVSLSGLGV----------------------- 346
XP_005464971 294 KTGINE---------------------------AWtVSKrGMPTTQVNLMSLPSLGI----------------------- 323
7_pfamImport 303 GGDIDE---------------------------SWtVIEaGMPTAERKLVSLAGLNA----------------------- 332
XP_006001076 314 RPDTGDTng---------------------pAKDWsAPLvRKTWGEHTL--FPSIGTwpgvdgrvkttgqntasfstlgl 370 coelacanth
XP_008106595 356 GKDTGDNg----------------------nGKDWgVSLvGRTWGERTL--FPGIAW----------------------- 388 green anole
XP_027705738 327 --STEQN------------------------SAPFpSLA-------LTT---AVSGS----------------------- 347 common wombat
XP_012427396 393 ----sgsN-----------SESVSq---A--------------------GTSDFQWDLSHAQTPVDDEWSG--LNGLSSA 432
6_pfamImport 376 -------N-----------ATETP----S--------------------NSAELQWASQKEANGANDDWSG--FARAAPA 411
Q9Z1W6       351 -------T-----------AEPVSq---S--------------------TTSDYQWDGSRNQPHIDDEWSG--LNGLSSA 387 Norway rat
1_pfamImport 345 -------N-----------ATAVSletiS--------------------NSM--EWAKPPDV---DNEWSG--YNGKAAA 379
XP_017207032 342 ----------------------------P--------------------AVPDLSWSAPPAVP-VDDEWSG--IKS-SSA 369
5_pfamImport 347 -------G-----------TTE---------------------------PASSLPWLSPPRV---DDEWSGpsFTGGTSV 378
XP_005464971 324 -------G-----------TAE-P----K--------------------PVNDLPWISQPRL---DDEWSG--LNG-GSV 354
7_pfamImport 333 -------E-----------------------------------------PVRDLPWIGQPRV---DDEWSG--LNG-SSV 358
XP_006001076 371 nssvsgsS-----------SEPVPq---S--------------------STTDLQWDS--VLTPIDDEWSG--ANGLPPA 412 coelacanth
XP_008106595 389 -------SgvdgrintpeqSSPSFs---SlglnpkvsgsssepvsqpgtTDFQWDLNRNQAHVDD--EWSG--LNGLSSA 454 green anole
XP_027705738 348 -------T-----------AEVSQ----S--------------------TASDFQWDVSRNQPHIDDEWSG--LNGLSSA 383 common wombat
XP_012427396 433 DPSSDWNAPAEEWGNWvdeEKV---ASVPQREERSDTQK 468
6_pfamImport 412 DPSSDWYAPVEHWGNY---EGVaamAAPPRKAEPAAAKV 447
Q9Z1W6       388 DPSSDWNAPAEEWGNWvdeDR----ASLLKSQEPISNDQ 422 Norway rat
1_pfamImport 380 DHSCDWNAPEEHWGNYe-ePPVlvtPAPPLKEPPVPNKV 417
XP_017207032 370 DPSCDWNAPSEEWGNYieqQPV---SAAPL-EQPGPEVL 404
5_pfamImport 379 DPSSDWNAPSEAWGNYe-ePAA---EPPPAAEPPAPEPA 413
XP_005464971 355 DTSSDWNAPSEAWGNYe-ePTL---EPPPAQEQPLPEPA 389
7_pfamImport 359 DPSSDWNAPAEVWGNYe-dPTS---AAPPLPQKLLPEPT 393
XP_006001076 413 DPSSDWNAPAEEWGNWveeEA----AQPPQPEEPVSEVQ 447 coelacanth
XP_008106595 455 DPTSDWNAPAEEWGNWveeEKS---PSIPQLEEGLSEAQ 490 green anole
XP_027705738 384 DPSSDWNAPAEEWGNWvdeEK----SSFLKSQELVHDEK 418 common wombat
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