1V26,1ULT


Conserved Protein Domain Family
ttLC_FACS_like

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cd05915: ttLC_FACS_like 
Click on image for an interactive view with Cn3D
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles
This family includes fatty acyl-CoA synthetases that can activate medium-chain to long-chain fatty acids. They catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family has been shown to catalyze the long-chain fatty acid, myristoyl acid, while another member in this family, the AlkK protein identified in Pseudomonas oleovorans, targets medium chain fatty acids. This family also includes an uncharacterized subgroup of FACS.
Statistics
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PSSM-Id: 213283
Aligned: 3 rows
Threshold Bit Score: 206.898
Created: 22-Jun-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:AMP binding site [chemical binding site]
Evidence:
  • Structure:1V26; Thermus thermophilus acyl-CoA synthetase binds AMP, contacts at 4.0A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
1V26_A     24 LERAAALFGRKEVVSRlht---gevHRTTYAEVYQRARRLMGGLralGVGVGDRVATLGFNhfRHLEAYFAVPGMGAVLH 100 Thermus thermophilus
1ULT_A     24 LERAAALFGRKEVVSRlht---gevHRTTYAEVYQRARRLMGGLralGVGVGDRVATLGFNhfRHLEAYFAVPGMGAVLH 100 Thermus thermophilus
Q9SFW5     13 PLSPISFLERAAVVFGsrtsvvygdIQYTWHQTRDRCVRLASALsdlGLSRHDVVAALAPNvpALCELYFGAPMAGAVLC 92  thale cress
Feature 1                                                                                     
1V26_A    101 TANPRLspKEIAYILNHAEDKVLLFDPNLlplveairgelktv---------qhfvvmdekapegYLAYEEALGEEadpv 171 Thermus thermophilus
1ULT_A    101 TANPRLspKEIAYILNHAEDKVLLFDPNLlplveairgelktv---------qhfvvmdekapegYLAYEEALGEEadpv 171 Thermus thermophilus
Q9SFW5     93 VLNTTFdsQMLAMALEKTKPKVFFVDSEFlsvaeeslsllsnieekpliititenpteqskyeqyEDFLSTGNPNFkpir 172 thale cress
Feature 1                 #                                                                   
1V26_A    172 rvPERAACGMAYTTGTTGlPKGVVYSHRALVLHSLAASLvdgtalsekDVVLPVVPMFHVNAWCLPYAATLVGAKQVLPg 251 Thermus thermophilus
1ULT_A    172 rvPERAACGMAYTTGTTGlPKGVVYSHRALVLHSLAASLvdgtalsekDVVLPVVPMFHVNAWCLPYAATLVGAKQVLPg 251 Thermus thermophilus
Q9SFW5    173 pvDECDPIALNFTSGTTStPKCVVYSHRGAYLNATAVGVmnem--kpmPVYLCTVPMYHCSGWCYIWTVTAFGGVIVCLr 250 thale cress
Feature 1                                                       ###                 ######    
1V26_A    252 prldpaSLVELFDGEGVTFTAGVPTVWLAladylestghrlkTLRRLVVGGSAAPRSLIARFERmgvEVRQGYGLTETSP 331 Thermus thermophilus
1ULT_A    252 prldpaSLVELFDGEGVTFTAGVPTVWLAladylestghrlkTLRRLVVGGSAAPRSLIARFERmgvEVRQGYGLTETSP 331 Thermus thermophilus
Q9SFW5    251 ev-ndeVIFDSIVKHKVTNFGGSPPVLNMianardsvkksfpWTVQVMSGGSSPPEVMLKLKKLg-fKVMMAYGCSEVYG 328 thale cress
Feature 1                                                                                     
1V26_A    332 VVVQNFVkshleslseeekltlkaKTGLPIPl-VRLRVADeegr-pvpkDGKALGEVQLKGPWITGGYYGNEEAtrsalt 409 Thermus thermophilus
1ULT_A    332 VVVQNFVkshleslseeekltlkaKTGLPIPl-VRLRVADeegr-pvpkDGKALGEVQLKGPWITGGYYGNEEAtrsalt 409 Thermus thermophilus
Q9SFW5    329 LGTACLWmpewetlpeeeslrlkaRDGLNHFakEAVDVLDpttmksvphDGKTIRVIALRGNTVMSGYFKDKEAtea-af 407 thale cress
Feature 1             #              # #   #    #                                             
1V26_A    410 pDGFFRTGDIAVWDEeGYVEIKDRLKDLIKSGGEWISSVDLENALMGHPkvKEAAVVAIPHPKWQERPLAVVVprg-ekp 488 Thermus thermophilus
1ULT_A    410 pDGFFRTGDIAVWDEeGYVEIKDRLKDLIKSGGEWISSVDLENALMGHPkvKEAAVVAIPHPKWQERPLAVVVprg-ekp 488 Thermus thermophilus
Q9SFW5    408 rGGWYWSRDMGVIDPdGYIQFKDRSQDVITCGGEIVGSKEIEGILYSHPavYDAGVVGRPDETLGESMCAFVKlkegaea 487 thale cress
Feature 1                                                   
1V26_A    489 TPEELNEHLLKAgf--aKWQLPDAYVFaeEIPRTSAGKFLKRALRE 532 Thermus thermophilus
1ULT_A    489 TPEELNEHLLKAgf--aKWQLPDAYVFaeEIPRTSAGKFLKRALRE 532 Thermus thermophilus
Q9SFW5    488 REEEIIEFCKRKlgnknMKMIPKTVVFs-DVPKTPTGKIRKNVLRK 532 thale cress

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