2VUT


Conserved Protein Domain Family
NmrA
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pfam05368: NmrA 
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NmrA-like family
NmrA is a negative transcriptional regulator involved in the post-translational modification of the transcription factor AreA. NmrA is part of a system controlling nitrogen metabolite repression in fungi. This family only contains a few sequences as iteration results in significant matches to other Rossmann fold families.
Links
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Statistics
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PSSM-Id: 398829
Aligned: 16 rows
Threshold Bit Score: 240.321
Created: 22-Mar-2022
Updated: 13-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2VUT_C         8 IAVVNATGRQAASLIRVAAA-----VGHHVRAQVHSL-----------------KGLIAEELQAIPNVTLfQGPlLN--- 62  Aspergillus nid...
NP_001236037   7 ILVLGPTGAIGRHIVWASVK-----AGNPTFILVRDTpasvnkprlvtaanpetREELIQSFQNSGVTLI-QGD-MN--- 76 
O65679        10 VLIIGATGRLGNYLTRFSIE-----SGHPTFALIRNTt----------------LSDKLKSLSDAGVTLL-KGS-LE--- 63  thale cress
P23762        67 IAVINAAGRQAASFIRVATA-----VGFHVRAQMRNL-----------------EGVVATEVSTNPNVTVlQGE-LYtke 123 Neurospora cras...
CCT65673      72 IAVINASGRQAASFIRVATA-----VGYHVRAQLRNL-----------------DGVVAAEVSGNPNVTVfVGE-LYtrh 128
Q6BYE2         5 LVVFGATGQQGSSVVSYVKErm--sDKFKIRAITRDP-----------------SKPEAKTLQESGVEVV-KAD-LG--- 60  Debaryomyces ha...
Q7S346         8 ITIFGATGLQGGSVAAIFLDdpklnADWTVRAVTRDV-----------------TKEGAKKLASQGAQVV-AAD-LN--- 65  Neurospora crassa
Q86IG4         5 VTVFGATGQQGSSVVRELLKn----GNFKVRALTRDP-----------------SSEASKSLKELGAEVVkSND-TD--- 59  Dictyostelium d...
Q86KD5         5 ITVFGASGQQGGGVVQALLKn----PNYKVRALTRNP-----------------ESETSLKLKEQGVEVVkCDD-SD--- 59  Dictyostelium d...
Q86I47         4 VTVFGSTGSQGGSVARALLK-----DGFKVRALTRNP-----------------ESENAKKLQKEGAEIVkCDD-AD--- 57  Dictyostelium d...

2VUT_C        63 ------------------------NVPLMDTLFEGAHLAFINTTsq----aGDEIAIGKDLADAAKRAGtIQHYIYSSMP 114 Aspergillus nid...
NP_001236037  77 ------------------------DHESLVNAIKQVDVVICSFG-------RLLIEDQVKIVAAIKEAGnVKRFFPSEFG 125
O65679        64 ------------------------DEGSLAEAVSKVDVVISAIP-------SKHVLDQKLLVRVIKQAGsIKRFIPAEYG 112 thale cress
P23762       124 tpaesdkgqcvdvtkngpisgigvNDALISELFRGAQLAFINTTf-----yGDEERIGMALADAAKKAG-VQHYVYSSMP 197 Neurospora cras...
CCT65673     129 qpseanrdv----tkhgplagvgvNYDVIASLFRGAQLAFINTTf-----yGDEIQIGKALADAAKRAG-IQHYVYSSMP 198
Q6BYE2        61 ------------------------DKQSIKQAFKGADTIFAMTAlnf--ggQTELEQGKLIADAAVEEK-VPNIIWSTLV 113 Debaryomyces ha...
Q7S346        66 ------------------------DKSSLRAAVDGAYAVFAVTNywekmdkDVEVQQGKNLVDAAAEAG-VQHFIWSSVL 120 Neurospora crassa
Q86IG4        60 ------------------------SKEAIQEVLKGSDAVFALTIaf----aQNETDVGKKIADAAFGAG-VKHFVFSGLP 110 Dictyostelium d...
Q86KD5        60 ------------------------SKEIIQEALSGSYGVFCVTNywg--yfEKEVEYGRNMADAALAAG-IKHFIFSGLT 112 Dictyostelium d...
Q86I47        58 ------------------------PKEVIEKALKGSDSVFCVTNfwa--yfGKELEYGLNIAHAALAAG-VKHFVFSGLA 110 Dictyostelium d...

2VUT_C       115 DHS-LY-GPWPAVPMWAPKFTVENYVRQL------GLPSTFVYAGIYNNNFTSLPYPlfQMELMPDG-TFEWHAPFDPDI 185 Aspergillus nid...
NP_001236037 126 LDVdRHdAAEPVREVFEEKAKIRRVIEAE------GIPYTYLCCHAFTGYFLRNLAQ--IDITVPPRdKVFIQGDGNVKG 197
O65679       113 ANPdKTqVSDLDHDFYSKKSEIRHMIESE------GIPYTYICCGLFMRVLLPSLVQ--PGLQSPPTdKVTVFGDGNVKA 184 thale cress
P23762       198 DHH-AYnKDWPSLPLWASKHRVEDYVKEI------GIPATFVYTGIYNNNFTSLPYPlfCTDLQPDG-SWIWQAPFHPNA 269 Neurospora cras...
CCT65673     199 DHG-AYnPEWPSLPLWAAKHEVEQYVRKL------RIPATFVYTGIYNNNFTSLQYPlfCMDLQKDG-SFKWQAPFHPDA 270
Q6BYE2       114 NANeISnGEFPHVVHFDEKAEVEKYIRSL------PINSSFFSPGCFMQNFLGMLKPqpVGDGKYSM--FNVLRPGS--E 183 Debaryomyces ha...
Q7S346       121 NINkLSkGKLPHLYHFDSKAEVEEYARSIa----tSLPSTFFLPGFYMSNFSGPALGltHHDTNTGKwTFALPTPASSSI 196 Neurospora crassa
Q86IG4       111 PCNkISnGRI-IVPHFDQKYLVEEYVRELses-npSFISSFVYAPFYYQNFKS-FVPkkNENGDGG---YTISLPSN--G 182 Dictyostelium d...
Q86KD5       113 PMNeISqGRF-SVPHYDQKYLIEKYIRELsklnpkTFISSFVYAPGYMQNFLTFYKLkkNIESDGSE-TYTLSTPSDPIG 190 Dictyostelium d...
Q86I47       111 PCNkISgGRY-NVPHFDLKHKIEEELRKMske-npSFVTSFVYAPFYMQNFKTFFAPkrTVNEATQEvTYVLGMPLNPKM 188 Dictyostelium d...

2VUT_C       186 PLPwldAEHDVGPALLQIFKDgPQKW-NGHRIALTFETLSPVQVCAAFSRA---LNRR---------------------- 239 Aspergillus nid...
NP_001236037 198 AYI---TEADVGTFTIEAAND-PRALnKAVHIRLPNNYLSLNDIISLWEKK---IGKTlekiyvs--------------- 255
O65679       185 VFV---NDVDVAAFTIKTIDD-PRTLnKTLYLSPPGNICSMNDLVELWEGK---IEKKlektfatenqllkkiketpypd 257 thale cress
P23762       270 KLPwldAEHDVGPAILQIFKDgVKKWgGGKRIALAYEMLTPLEACEVFSRG---VGRP---------------------- 324 Neurospora cras...
CCT65673     271 KLPwldAEHDVGPAVLQIFKDgPSKW-NGERIALAYEYLTPKEVCRLFSKG---VGRP---------------------- 324
Q6BYE2       184 VPFf--DTEDTGKFVGAILNE-PEKF-HGKILYAANGMYSYETIAKIISKD---TGKK---------------------- 234 Debaryomyces ha...
Q7S346       197 FPLf--DTADTGKFVKAAVLH-REET-LGKRLLGATEYLTGDQVVEGFKKVfpeAGAT---------------------- 250 Neurospora crassa
Q86IG4       183 KPMdmgDVDNIGAIVCEILLN-ENKY-SGVVVPFSGGALSGPEIANIFSKV---SGKS---------------------- 235 Dictyostelium d...
Q86KD5       191 KPLdigDITEMGYIVESILSD-PIKY-SGSVIPMSGDCLTGPQIAEIYSKV---TGKT---------------------- 243 Dictyostelium d...
Q86I47       189 LPLdmgDINDIGSIVAVMMKD-PTKY-SGKIIPFSGDCLHGEKIAEIMSKV---TGKK---------------------- 241 Dictyostelium d...

2VUT_C       240 -----------------------------------VTYV 243 Aspergillus nidulans
NP_001236037 256 ----------------------------eeevlkqIket 266
O65679       258 nmemvfiysvfikgdhtyfdiescggvngtelypdVKYM 296 thale cress
P23762       325 -----------------------------------VRYV 328 Neurospora crassa OR74A
CCT65673     325 -----------------------------------VRYV 328
Q6BYE2       235 -----------------------------------VNYQ 238 Debaryomyces hansenii
Q7S346       251 -----------------------------------ASYY 254 Neurospora crassa
Q86IG4       236 -----------------------------------VTFK 239 Dictyostelium discoideum
Q86KD5       244 -----------------------------------VNFE 247 Dictyostelium discoideum
Q86I47       242 -----------------------------------VVYN 245 Dictyostelium discoideum
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