4MXW,2RJK,1TNR,1DG6,5BNQ,4HT1,6MKB,6CU0


Conserved Protein Domain Family
TNF

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pfam00229: TNF 
Click on image for an interactive view with Cn3D
TNF(Tumour Necrosis Factor) family
Statistics
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PSSM-Id: 425540
Aligned: 27 rows
Threshold Bit Score: 84.6729
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam00229 is a member of the superfamily cl00147.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4MXW_B    60 LGWETTKE--QAFLTSGTQFSDAEg-LALPQDGLYYLYCLVGYR--GRAPPGGgdpqgrSVTLRSSLYRAGGAYgpGTPE 134 human
5BNQ_A    28 SSWYHDR---GWAKISNMTFSNGK--LIVNQDGFYYLYANICFR--HHETSGDla--teYLQLMVYVTKTSIKI--PSSH 96  human
AAG47640  84 hTWANKS---FGAHLYNMTLTNGR--LRVPQDGRYYLYSQVYFR--YPSPSDSdqs-svSHQLVQCIYKKTS-Y--LNPI 152
Q9I8D8   152 LKWMTTS---YAPTSSLISYHEGK--LKVEKAGLYYIYSQVSFCt-KAAAS---------APFTLYIYLYLPM---EEDR 213 chicken
P27548   137 LQWAKKGY--YTMKSNLVMLENGKq-LTVKREGLYYVYTQVTFC--SNREPSS------QRPFIVGLWLKPSS---GSER 202 house mouse
O97605   137 LQWAPKGY--YTISSNLVTLENGKq-LAVKRQGLYYIYAQVTFC--SNREASS------QAPFIASLCLHSPS---GSER 202 domestic cat
4HT1_T    36 SGWEEARI--NSSSPLRYNRQIGE--FIVTRAGLYYLYCQVHFD---EGKA---------VYLKLDLL--------VDGV 91  human
P32971   113 LSWNKDGI------LHGVRYQDGN--LVIQFPGLYFIICQLQFL---VQCPNN------SVDLKLELLINKH----IKKQ 171 human
P32972   118 LSWNEDGT------IHGLIYQDGN--LIVQFPGLYFIVCQLQFL---VQCSNH------SVDLTLQLLINSK----IKKQ 176 house mouse
6MKB_D    26 LNWHSQDGagSSYLSQGLRYEEDKkeLVVDSPGLYYVFLELKLSptFTNTGHK------VQGWVSLVLQAKPQV--DDFD 97  house mouse
4MXW_B   135 LLLEGAE-TVTPVLDPARrqgygplWYTSVGFGGLVQLRRGERVYVN--ISHPDMVDFA--RGKTFFGAVMV 201 human
5BNQ_A    97 TLMKGGS-TKYWSGNSEF-------HFYSINVGGFFKLRSGEEISIE--VSNPSLLDPD--QDATYFGAFKV 156 human
AAG47640 153 QLLKGVG-TKCWAPDAEY-------ALHSVYQGGLFELRAGDEVFVS--VSSPTMVYGE--DSSSYFGAFRL 212
Q9I8D8   214 LLMKGLDtHSTSTALC---------ELQSIREGGVFELRQGDMVFVN--VTDSTAVNVN--PGNTYFGMFKL 272 chicken
P27548   203 ILLKAANtHSSSQLC----------EQQSVHLGGVFELQAGASVFVN--VTEASQVIHR--VGFSSFGLLKL 260 house mouse
O97605   203 VLLRAANaRSSSKPC----------GQQSIHLGGVFELHPGASVFVN--VTDPSQVSHG--TGFTSFGLLKL 260 domestic cat
4HT1_T    92 LALRCLEeFSATAASSLGp------QLRLCQVSGLLALRPGSSLRIR----TLPWAHLKaaPFLTYFGLFQV 153 human
P32971   172 ALVTVCE-SGMQTKH----------VYQNLSQFLLDYLQVNTTISVN--VDTFQYIDTStfPLENVLSIFLY 230 human
P32972   177 TLVTVCE-SGVQSKN----------IYQNLSQFLLHYLQVNSTISVR--VDNFQYVDTNtfPLDNVLSVFLY 235 house mouse
6MKB_D    98 NLALTVElFPCSMENKLVdr----sWSQLLLLKAGHRLSVGLRAYLHgaQDAYRDWELSy-PNTTSFGLFLV 164 house mouse
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