6RXT


Conserved Protein Domain Family
Bystin

?
pfam05291: Bystin 
Bystin
Trophinin and tastin form a cell adhesion molecule complex that potentially mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of implantation. Trophinin and tastin bind to an intermediary cytoplasmic protein called bystin. Bystin may be involved in implantation and trophoblast invasion because bystin is found with trophinin and tastin in the cells at human implantation sites and also in the intermediate trophoblasts at invasion front in the placenta from early pregnancy. This family also includes the yeast protein ENP1. ENP1 is an essential protein in Saccharomyces cerevisiae and is localized in the nucleus. It is thought that ENP1 plays a direct role in the early steps of rRNA processing as enp1 defective yeast cannot synthesize 20S pre-rRNA and hence 18S rRNA, which leads to reduced formation of 40S ribosomal subunits.
Statistics
?
PSSM-Id: 461612
Aligned: 86 rows
Threshold Bit Score: 329.465
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
6RXT_CX      161 QTNLADLILQKIAEKEAMTG-GQN-GGN-------PIEeDYEIPPKVVEVFTKIGLILARYKSGPLPKPFKVLPT--IPH 229
CBJ32010     104 RRSLADIIMEKIREKEEGETrAAGmGGGgd----eDEDgMPRLPPKVVEVYGAIGKMLKSYTAGKLPKAFKIIPS--LTN 177
XP_004351477 206 rFTLGQLIEAKLKEQEEKES-MV-------------KEpRQKMNPKVLEVYKKVGQMLAHYRSGKVPRAFCILPN--FTN 269
Q54IS0       182 RFTLGDIIESKLKEHESRQV-----------------SsENAINPKVIDVYTKVGKLLETYTSGKIPRAFRILPN--FTN 242 Dictyostelium d...
ESS31277     144 APTLADFILEKLRQKEERES-SGAaAEA-------PEEdCSALPPKVVEVYTAMGSFLQKYRSGKMPKAFKVLPR--LQR 213
XP_001325919 101 AKQLFELFKADVVQTSNKLN-STLeKTAhi------------sDQSVVEIYQKLGVLLRNYKSGKLPKAINVIASqnIPD 167
A0DVD2       145 TNQIIEDFQKGLQDDENKKH-----------------HeNIMNNPKVVCVYENVAELMKTYRSGKLPQPFHLIPK--LEH 205 Paramecium tetr...
Q8IIR2       133 SKDIFEELNIKIMNDSKHVSyNKMeNTTqe----pNPStEDKVNLLVEKCYRTIGEDLAHYKSGKLHRALTILTK--SSK 206 Plasmodium falc...
EFJ50348     168 QTSLADLILARLKEQQAERG-LPQlPEEgadpgadPGPlPEGLEPRVVEVYRGVGKLLSRYTTGKIPKAFKIIPN--LRN 244
EFN54310     145 QRTLADLVLERIREKQAEQG-VSEiPREg------QEFvPDELDPKVVEVYQGVGKVLSRYTAGKVPKAFKVIPN--LQN 215
6RXT_CX      230 WEDIIQLTRPDL------------WTPNACYAATRIFVSA-KPQVVQRFMEMIILERVREDIHENKKLNVHLFNCLKKAL 296
CBJ32010     178 WEQVLWLTRPEQ------------WSSHAMLAATKIFASNfNAKMAQRFYNVFLLEACRTDILENRRLNYHLYEALRKSV 245
XP_004351477 270 WEDLIYLTRPDL------------WTPHAVREATKIFVMSsNARQTQRFLSLVLLPRVRDNIAEFRKLNFHLYMALKKSL 337
Q54IS0       243 WEDLLYLTRPDK------------WTPHSIRVATKLFCMStNSKITQRFLSIVVLPRVRDNIAEYKKLNYHLYMALKKSL 310 Dictyostelium d...
ESS31277     214 WEEVLLLTQPES------------WSRQAMFEATKIFTSNlSSAGAQRFLCLVLLPAVRSDISTNKKLNYHLYQALKKAL 281
XP_001325919 168 WFELLQYSEPEN------------WSANAIKEVTTLFAQTsSEARCNKFYREVLLEYIKNLLDDNKKLPRNVWDALVAAA 235
A0DVD2       206 WKQVFELTKPSE------------WSPQAIFAATKIFSSAlDRQQTEYLYSTVILPAIRLSIQEDKRLNVHLYNALIKAM 273 Paramecium tetr...
Q8IIR2       207 WYEYLLLTKPKK------------WTAHATFEITKLFSSGlKEKEVSKFYEFILLPIVLENIDKNKKLDAFLYKALIKAL 274 Plasmodium falc...
EFJ50348     245 WEDVLYLTDPGKdfrssvnqnrysWSVHAMYQASRLFVSNlNARLAQRFLALVLLPRVRAEIRQHKRLHFALFQALRKAT 324
EFN54310     216 WEEILYLTDPDN------------WTPHAVYQATRMFVSNlNQKMSQRFLVLVLLPHVRADIRKNRRLHFALFMALKKAT 283
6RXT_CX      297 YKPAGFFKGFLFPLAASGTCTLREAQIISAVLARISIPVLHSAAAIKTLCDIaaeqasqraECVSATNYLLKVLLEKRYA 376
CBJ32010     246 YKPAAFYKGMLLPLASAGDCTLREAAIFASVLSRVTIPANHSAVALLKLAQL---------PYNGATSLFIRVLLNKKYA 316
XP_004351477 338 YRPQAFYKAIFLPLAEEGDATLLEAKIIASVVKKVSVPVIHSSVALLKLAQIp--------KYNGATSLFIMTLCDKKYS 409
Q54IS0       311 YRPAAFYKAILLPLAESGDCTLLEAKIIGSVVCKVSIPVLHSSVALMKLSQLt--------RYNGATSMFIRMLCDKKYA 382 Dictyostelium d...
ESS31277     282 FKPAAFFKGIFLPLALEG-CSNREAIIVGSVVAKVSIPVLHAAAALMRLALVpp------pQWLPAVSVLMGLLINKKYS 354
XP_001325919 236 RRPKPFILALMMPLAAQDNCSPKDARVISAMVNRVKLPNDLVNSFLVWLCEGk--------PITLPRTIFVIRFVQKGKV 307
A0DVD2       274 YKPQAWFRSILFPLCLEKDFTLKEAQIIGSVIHKLHVPPIHGSIAIFKVAQL---------DFTGPVAVILKVLIEKKFS 344 Paramecium tetr...
Q8IIR2       275 YKSKSWFKGILFPIL-HRECTKKQMIIIGSVIQKMSISINCVVLALDEIFSF---------SWNSIISYILILLFNKKYA 344 Plasmodium falc...
EFJ50348     325 YKPGAFYKGILLPLCQSRTCTLREAVILTSVLKRASLPVLHSAAALLRLAQL---------EYCGTTSFFMRVLLDKKYA 395
EFN54310     284 YKAAAFYKGVLLPLCASGTCNLREAVILTSVIKRTSIP-------------M---------PYSGTNSFFLRVLLDKRYA 341
6RXT_CX      377 LPWQCIDALVFHFLRYASMareGdgapkaLPVIFHQCLLVFAQRYRNDITEDQREALL-DLLLTHGHEKIAPEIRKELLA 455
CBJ32010     317 LPYKVIDSLVDHFMTFTTEt-rV------LPVLWHQSLLVFAQRYRGDITRADKDRLK-ELLKAQQHHQITPEVRRQLFM 388
XP_004351477 410 LPLRVVDSLYQHFISFVDEr-rD------LPVLWHQSLLMFVQRYKNDIKPQHKENLK-ILLRNQFHHQITNEIRRELFN 481
Q54IS0       383 LPYRVIDGLVDHFVMFDEEv-rE------LPVLWHRALLSFVQRYKTDITKDQKEKLK-IILRKHNHHIITAEIRRELFF 454 Dictyostelium d...
ESS31277     355 LPVKAVQACVAHFHRFAERad-------lLPVAWHQALLVFVQRYKFCLSEDERSMLK-EVLRVHFHEKIGPEIRRELLA 426
XP_001325919 308 LAIRAVDAVYGYFMQFAAEte-------qQPVIWHKALKDFAKHYARDLTQEQKEIMVgDLLQKQHKSGITPEIREIIMK 380
A0DVD2       345 LPERALDEVIKYFMRYENDq-rE------MPVIWHQMILRVCELYQ--LKQDHKDQLK-KLINKKKHHLITKEIQKQLKQ 414 Paramecium tetr...
Q8IIR2       345 FTKQCIDNCVNYFLRFENYqd-------vLSINWHKSLLTLVHNYRGLMCDTQVEALT-HLVKKKNHHQISSEIMKHLYS 416 Plasmodium falc...
EFJ50348     396 LPYRVIDALVDHFVRFADDe-rQ------MPVVWHQTMLCFVQRYKHEVRADDLLALR-ALCGKQHHYKVTPEVLRELDH 467
EFN54310     342 LPYRVVDALVDHFLRFKTEe-rQ------LPVVWQQTLLCFVQRYKTEIRREDKHALR-DLVKRQHHYALTPAILRELDS 413
6RXT_CX      456 GRGRGIP 462
CBJ32010     389 GSCRGEP 395
XP_004351477 482 NQSSQQS 488
Q54IS0       455 SNSRGGV 461 Dictyostelium discoideum
ESS31277     427 KQAALVL 433
XP_001325919 381 SPTREeg 387
A0DVD2       415 RHQNGCR 421 Paramecium tetraurelia
Q8IIR2       417 PTSLMNK 423 Plasmodium falciparum 3D7
EFJ50348     468 ALGRGga 474
EFN54310     414 SLSRGEQ 420
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap