Conserved Protein Domain Family
AKR_AKR6C1_2

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cd19143: AKR_AKR6C1_2 
AKR6C family of aldo-keto reductase (AKR)
Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Statistics
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PSSM-Id: 381369
Aligned: 34 rows
Threshold Bit Score: 543.343
Created: 19-Apr-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Rattus norvegicus voltage-dependent K+ channel beta subunit (3EAU) binds cortisone and cofactor NADPH.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                       ###     #                     #    #                          
O23016      1 MQYKNLGKsGLKVSTLSFGAWVTFGNQldVKEAKSILQCCRDHGVNFFDNAEVYAnGRAEEIMGQAIRelgWRRSDIVIS 80  thale cress
OGW63566    1 MNYRRLGHsGLKVSELSLGAWITYGGQvgEDAARECMSAGYDAGVNFFDNAEAYAhGAAETIMGNVIRkmgWRRSSLVVS 80  Nitrospirae bacter...
NP_228125   1 MEYRKVGKwGVKISELSLGSWLTFGKQldLDTATEVVKKAFNSGINFFDTAEAYAgGIAEAMLGKILKn--FRREDLVVS 78  Thermotoga maritim...
OGV42982    1 MQYRHMGKwGLKLSELSFGSWITFGRNldIQAVRMCMRTAFDHGVNFFDNAEAYGrGVSEMLMGEALRe--FPRDQVAIS 78  Lentisphaerae bact...
EFB42096    1 MEYRRLGKaGLKVSELSFGSWITFGSNlnLNNIRQCLKMAFDAGINFFDNAEVYAnGASELLMGEAIKd--LRREDLVIS 78  Parachlamydia acan...
KJF17738    1 MEYRRLGRsGVKVSALSLGSWVTFGTAvdTDLAVATMKVAREAGVNFFDNAEAYAgGQSEELMGKALRklkWRRNSYLVS 80  acid streamer bact...
EMS25181   10 MQYKHLGPtGLLVSVLSYGGWLTVGGSvkGQTNTDLIKCALDHGVNFFDNAEVYAnGESEIAMGQAFKeldVDRSQIVVT 89  Rhodosporidium tor...
EAA36333   62 MKFRYLGNtGLQVSIFSLGGWLTYGGTqkGEIVKKCLQTAWNHGIQTFDTAEVYAnGASEVEMGQALKelgWPRDEYVLT 141 Neurospora crassa ...
CAK64528    1 MEYRRLGAtGLKVSAISYGNWVNSDDKdtQDRNTKIIQKAWELGINFFDTAEIYGdGKAEIHLGHALKtlnVQRQDIVIS 80  Paramecium tetraur...
PRP82839   12 MQFRHLGAtGLKVSVLSLGGWLTYGGTvkGNPVKDCLEAAWNHGINFFDTAEVYSnGECELEMGKALQelnWPRDEYVIS 91  Protostelium sp. J...
Feature 1      #                                         #                              ##    
O23016     81 TKIFWGGpgp--ndkGLSRKHIVEGTKASLKRLdMDYVDVLYCHRPDASTPIEETVRAMNYVIDK-GWAFYWGTSEWsAQ 157 thale cress
OGW63566   81 TKFYFGLglkgpndrGLSRKRLMEGIHGSLRRLqMDYVDLIFAHRPDPETPIEETVRAMHDIIGQ-GKALYWGTSEWtAD 159 Nitrospirae bacter...
NP_228125  79 TKIFWGGsgp--ndlGLSKKHLLEGTWNSLKRLqMDYVDILYCHRPDPNVPMEEVVFAMDYILRE-GLALYWGTSEWsAK 155 Thermotoga maritim...
OGV42982   79 TKIFWGGdgv--ndtGLNAKHLIEGTKRSLRRLgLEYVDLLFCHRPDPETPIEETVRAMDVLLRQ-GLAIYWGTSEWsAE 155 Lentisphaerae bact...
EFB42096   79 TKIFWGGkgp--natGLNWKHLVEGTKGSLRRLqLDYVDLLFCHRPDPTTPIEETVRAMDVLVRS-GLAFYWGTSEWrAE 155 Parachlamydia acan...
KJF17738   81 SKYFWGLndgvnernTLNRKYLLDAIDGSLERLgLSFIDIAYCHRPDPETPIEETVRAMNDIIDR-GKALYWGVSEWsAA 159 acid streamer bact...
EMS25181   90 TKIFFGTgksdpnqrGLSRKHIIEGMRASLKRLqLDYVDVVFAHRPDVATPMEEFVRAMNWVIDQ-GWAFYYGTSEWtAQ 168 Rhodosporidium tor...
EAA36333  142 TKVFFGTgrkepntrGLSRKHIVEGLKASVNRLqTPYVDVVFAHRPDAATPMLEIVEAFTQVIRNlNLAYYWGTSEWsAV 221 Neurospora crassa ...
CAK64528   81 TKIYGGDgndfpnskYLSRKHLIEGLRNSLKRLdTPYVDIVFAHRYDYQTPLEETCRAFDWIIRH-GLAHYWGTSEWtAQ 159 Paramecium tetraur...
PRP82839   92 TKVFFGTgrkepntrGLSRKHVVEGLKSSLKRLqLDYVDVVFAHRPDPATPMKEIVEGFTQVIRNlNLAYYWGTSEWsAR 171 Protostelium sp. J...
Feature 1                         #                            ######   # #        ###        
O23016    158 QITEAWGAAdRLDLVGPIVEQPEYNMFARHKVEtEFLPLYTNHgIGLTTWSPLASGVLTGKYnkgaIPSDSRFALENYKN 237 thale cress
OGW63566  160 EIVQAHAVAeGHHLHKPQMEQPQYNMFWRERVErQYARLYTEIgLGLTTWSPLASGLLTGKYse-gIPAGSRLALKGMEW 238 Nitrospirae bacter...
NP_228125 156 EIEEAHRVCkELGVMPPIVEQPQYNMFVRERVEkEYAPLYEKYgMGLTTYSPLASGLLSGKYnn-gIPEGSRLATFPQVR 234 Thermotoga maritim...
OGV42982  156 EIETAHRWCrEMNVAPPCVEQPEYNLFVRDRVEkEYVPLYEKYgMGATIWSPLAGGILTGKYnn-gIPPGSRLEHQEWLR 234 Lentisphaerae bact...
EFB42096  156 DIEEAHQIArAIHAIPPAMEQPEYNMFQRARVEeEYASLYHKYgMGTTIWSPLESGILTGKYne-eIPPGSRLYRHEELR 234 Parachlamydia acan...
KJF17738  160 EIRNAYEIAdRYGFHKPVTEQPQYNLFHRKRVEvEYEEIFRDFkMGTTTWSPLASGLLSGKYvn-gIPEGSRGALSGYEW 238 acid streamer bact...
EMS25181  169 QIQEAIGIAdRLGLQRPIVEQPQYSILHREKFEvEYAPLFKNYgLGTTIWSPLAGGELSGKYan-gIPEDSRWKTNPNFY 247 Rhodosporidium tor...
EAA36333  222 QIKEAIHLAdKHNLIAPVVEQPQYNAFHRERFEnEYAPLFKEHgYGTTIWSPLASGLLTGKYnd-gIPEDSRFATNKAFF 300 Neurospora crassa ...
CAK64528  160 QIHQAIGICdRLSLHKPVVEQPQYNMMVRDRFEwEYESVFASG-YGSTIWSPLYQGLLTGKYnd-dILADGRFNNSDNIY 237 Paramecium tetraur...
PRP82839  172 QIEEAIQIAeRYNLIAPVVEQPQYNAFHRERFEvEYAPLFKQYgYGTTIWSPLASGLLTGKYne-gIPKDSRFSNNSQFF 250 Protostelium sp. J...
Feature 1                                         #                #####   #  ##              
O23016    238 LAnrs--------lvDDVLRKVSGLKPIADELGvtLAQLAIAWCASNPnVSSVITGATRESQIQENMKAvDVIPLLTPIV 309 thale cress
OGW63566  239 LReev--------vtPERIEKVKRLAMVARDLEmsTAQLAIAWCLKNPnVSSVITGATRVEQVRENLKAaELSDKLTPDA 310 Nitrospirae bacter...
NP_228125 235 KWleeg-----gllnEKTFKKLRKLQNIADQLGasLPQLAIAWILKNKnVSSVILGVSRPEQLEENLKAvEIKEKLTEDV 309 Thermotoga maritim...
OGV42982  235 QTl-----------tPERIQVVKELMQTAGELGcsVGQLALAWCLKNPrVSTVIMGAAQLAQLEENLQAvEVKKQLTDEV 303 Lentisphaerae bact...
EFB42096  235 NRl-----------tKEKIAKVKALEKIAHELSctLSQLAIAWCLKNPhVSSVILGASSIPQLQENLGAeQVKLQLTDEV 303 Parachlamydia acan...
KJF17738  239 LTpsl--------tdPSKNNVVGELAKLAAEIGatPSQLAIAWCLLNPnVSTVITGATSIAQVNENMESiKVLSSLTPEI 310 acid streamer bact...
EMS25181  248 EKqikey---espegQARQAKIRKLGDVAKRLDstTAAVALAWCAKNPnVSTVILGATKVAQLEENFKAlDVLPKITDDI 324 Rhodosporidium tor...
EAA36333  301 ENtiksl---qseegQAKIEKVRKLTKIAERLGatVTHLALAWAAKNPnVSTVILGATKVEQIEDNLKAlPLIDKLTPEI 377 Neurospora crassa ...
CAK64528  238 VKhfyqqilgdpekrTKIQNQLKQLGEVAKELGvtQAQLSLAWALKNKdVSTAITSATRPEQLEETVKSvQVVKLITKEV 317 Paramecium tetraur...
PRP82839  251 NDtikel---etpkgKEKIEKVKKLTAIAERLGgsTTQLALAWAAYNQnVSTVILGASKPEQIDENVKSlEILAKLTPEI 327 Protostelium sp. J...
Feature 1            
O23016    310 LDKIEQV 316 thale cress
OGW63566  311 MERIEKV 317 Nitrospirae bacterium RBG_16_64_22
NP_228125 310 MEEIEKI 316 Thermotoga maritima MSB8
OGV42982  304 MKRIRQI 310 Lentisphaerae bacterium GWF2_57_35
EFB42096  304 MQAIEGI 310 Parachlamydia acanthamoebae
KJF17738  311 AQRIQAI 317 acid streamer bacterium Py-F3
EMS25181  325 VKEIDEI 331 Rhodosporidium toruloides NP11
EAA36333  378 MEEIESV 384 Neurospora crassa OR74A
CAK64528  318 EQKIESI 324 Paramecium tetraurelia strain d4-2
PRP82839  328 KKEIDDI 334 Protostelium sp. Jena Gg-2016a

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