Conserved Protein Domain Family
TGF_beta_INHBC_E
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cd19406: TGF_beta_INHBC_E 
transforming growth factor beta (TGF-beta) like domain found in inhibin beta C chain (INHBC), inhibin beta E chain (INHBE) and similar proteins
The family includes INHBC and INHBE. INHBC, also termed activin beta-C chain, might play important roles in carcinogenesis. It may function as a negative regulator of liver growth. INHBE, also termed activin beta-E chain, is a possible insulin resistance-associated hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. It also acts as a possible new marker for drug-induced endoplasmic reticulum stress.
Links
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Statistics
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PSSM-Id: 381676
Aligned: 9 rows
Threshold Bit Score: 213.093
Created: 19-Jul-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Download Cn3D
 
putative
Feature 1:putative homodimer interface [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens INHBA (1NYS) forms a homodimer.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                            ## #        
P55103       247 CCRQEFFVDFrEIGWHDWIIQPEGYAMNFCIGQCPLHiAGMPGIaASFHTAVLNLLKANtaagttgggSCCVPTARRPLS 326 human
P58166       247 CCRRDHYVDFqELGWRDWILQPEGYQLNYCSGQCPPHlAGSPGIaASFHSAVFSLLKANnpwp--astSCCVPTARRPLS 324 human
CBN80830     271 CCKRDFYIKFkDIQWHDWIIAPEGYHMNYCMGQCPQHlSGSPGIaSSFHATVFSQLKVNgint--aasSCCVPTERRPLS 348 European seabass
XP_002199911 253 CCRREFFVDFkEIGWEDWIIQPEGYHMNYCAGLCPLHmAAIPGLaASFHTAVLNRVKAAsaaa--avdSCCVPTQRRPLS 330 zebra finch
XP_014348699 256 CCKKDFYMDFkDIGWNDWIIKPEGYHMNYCMGLCPLHiAGTPGIaASFHTAVFNLIKANniht--avnSCCVPTKKRPLS 333 coelacanth
NP_001079333 264 CCRKDYYVDFkDIGWNDWIIKPEGYQINYCMGLCPMHiAGAPGMaASFHTTVLNLIKANniqt--avnSCCVPTKRRPLS 341 African clawed ...
XP_012959130 469 CCRKDYYVDFrDIGWNDWIIKPEGYQINYCVGQCPLHvAGSPGMaSSFHTAVFNLVKANniqa--sghSCCVPTRRRPLS 546 mallard
XP_015128061 246 CCRRDHYVDFrAIGWNDWIISPEGYQLNYCVGQCPLHvAGSPGMaSSFHSAVLSLVKANnvrt--aahSCCVPTRRRPLS 323
KYO34905     249 CCLQDYYVDFrAIGWHDWIIKPEGYQLNYCVGQCPLHvAGSPGMaASFHSAVLNLVKANsiag--aghACCVPTHRQPLS 326 American alligator

Feature 1                    #  ##        #
P55103       327 LLYYDRDsnIVKTDIPDMVVEACGCS 352 human
P58166       325 LLYLDHNgnVVKTDVPDMVVEACGCS 350 human
CBN80830     349 MVYFNSQhsIVKTDVPDMIVESCGCT 374 European seabass
XP_002199911 331 LLYYDRDsnIVKTDIPDMIVDSCGCT 356 zebra finch
XP_014348699 334 MLYFDRDsnIVKTDIPDMIVEACGCT 359 coelacanth
NP_001079333 342 MLYFDRNnnVLKTDIADMIVEACGCS 367 African clawed frog
XP_012959130 547 VLYFDRNsnIVKTDIPDMIVDACGCS 572 mallard
XP_015128061 324 LLYFDRNsnIVKTDIPDMIVDACGCS 349
KYO34905     327 VLYFDRGsnIVKTDIPDMIVEACGCS 352 American alligator

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