5A7Z,4JWJ,4JWG,4JWF,4JWJ,4JWH,4FMW


Conserved Protein Domain Family
SPOUT_Trm10-like
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cd18089: SPOUT_Trm10-like 
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tRNA methyltransferase Trm10-like
Family of tRNA methyltransferase Trm10-like proteins catalyzes the N(1) methylation of guanine at position 9 (m(1)G9) of tRNA (eukaryotes) or N(1) methylation of guanine or adenine at position 9 (m1G9/m1A9) of tRNA (archaea), which might play a role in the stabilization of tRNA and in translation termination efficiency. Trm10 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Links
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Statistics
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PSSM-Id: 349962
Aligned: 96 rows
Threshold Bit Score: 86.4353
Created: 15-Aug-2016
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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SAM binding
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:SAM binding site [chemical binding site]
Evidence:
  • Structure:4JWJ; Saccharomyces cerevisiae Trm10 bound to SAM, contacts at 4.0A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
5A7Z_A    108 PKXVIDLGLFeflneEEKEKTLLQVDLCLSVIRkfl--wdGNLTVVgkady------------------vlgrANIVQsl 167 Sulfolobus acidoca...
4JWJ_B     21 IEIILDCSFDelmndKEIVSLSNQVTRAYSANRran--hfAEIKVApfdkrlkqrfet---tlkntnyenwnhFKFLPdd 95  Saccharomyces cere...
CUX77882   99 PWIIVDLMFWdkhipKEKGKVTLQLRETYAVMRrmf--wpRKLAITwvneefk--------------rmsklpLNKVEaf 162 Thermococcus chito...
KUK01605   96 PYFIIDLMYWdehtdKEKRKLALQLNQSYGLIRdyl--wgERLVLTwlnkrae--------------ssmhfpLQRITsf 159 Methanobacteriacea...
CEF98121  484 LRVAVDVSYEqd-saRARRSVAKQLCECVGVAHre---daLAMTYCafqgdiaqe---------arefffsdgWTSVRte 550 Ostreococcus tauri
CCO15853  598 LKVIVDLSYEhd-saRALRSVAKQLCEITSVGKksk--gdLRVTFAsfagdikye---------setffnadtWSKHVem 665 Bathycoccus prasinos
ACO61137  675 LRIAIDTGYDqd-sqRAVRSVAKQLAECIGVKRralkvepSQVDTTpvdvdltfagwrgvvaahaadhfnadrWSEVRkd 753 Micromonas sp. RCC299
EEY65902   63 IQVVVDLAFAldqttRESHSILKQLGCVYGYLKtcpldrlLSLHLAsctqg------------------lasiCAQHAgr 124 Phytophthora infes...
EZG45076   80 LHICIALDFMddmspREKNSLARQIQWVWNDIVrkp-elkIKLDLApfaagcpfeed------crrfgfvhwkMNYRPqs 152 Gregarina niphandr...
AFZ81369   36 VGVCINCSFNeimnpREIRSLAKQLSMSYNLIKkhm--apIKMVLTsfshdsalyk--------dcelfgiqnWKIHKhe 105 Babesia equi strai...

Feature 1                                          ###                   ## # # #  #  ##      
5A7Z_A    168 sl---------------------------sdedNPVILDPYGDVVATDqilr-dhnVFVIGGIVDKGr-RLDRATERLAl 218 Sulfolobus acidoca...
4JWJ_B     96 kimfg---------------------dehiskdKIVYLTADTEEKLEKlep---gmRYIVGGIVDKNr-YKELCLKKAQk 150 Saccharomyces cere...
CUX77882  163 egstae-------------------flklkgieRVVLLDPNAQEVLSQddl--kekAFIIGGIVDMKgdKKGTTAKIGEe 221 Thermococcus chito...
KUK01605  160 kgpthk-------------------flaengmrEAILLDPWAEKDIKPedf--iskAFIIGGIVDKTgnKKGATPRMGEk 218 Methanobacteriacea...
CEF98121  551 srave----------------------dafdpsSVVYLSPDATDVLDEvrs---dkVYVIGGIVDLAt-RGIPTSLTRAt 604 Ostreococcus tauri
CCO15853  666 lpdpaeecdv------------vacqeegqtknNVIYLSPDAETPLSLselrdpsnIFVVGGIVDLKt-RGMKTSKKKAs 732 Bathycoccus prasinos
ACO61137  754 prdvedifmrggdgggdgvdgvdgppeggaptaKVVYLSPDAEEVLEDvep---gtVYVIGGIVDLAa-RGVAWSLPKAn 829 Micromonas sp. RCC299
EEY65902  125 heepl---------------------eqlydadKLVYLSPDSDNVLEHldp---afVYIVGGIVDRSv-RKGETKTKAAs 179 Phytophthora infes...
EZG45076  153 fhe-------------------------eypmeRVVVLSPDAETALTQadlqddrtVFVIGGIVDKTv-KRNMTKDLADq 206 Gregarina niphandr...
AFZ81369  106 qgfw-----------------------eifeseKIIVLTPDATEILEEiqh---dkVYIIGGLVDTNv-KKRETLTQASk 158 Babesia equi strai...

Feature 1               ###                ## #  #                               
5A7Z_A    219 srg--ysfpRVKIQLrgsi-------igvPDEINKILEIILRVKel----------dqSLEEAIISL 266 Sulfolobus acidocaldarius
4JWJ_B    151 mg-----ipTRRLPIdeyin----legrrVLTTTHVVQLMLKYFdd-----------hNWKNAFESV 197 Saccharomyces cerevisiae S288c
CUX77882  222 leskgiemlRRKIVLrgdi-------vgvPDRINHIAEILLRMLyg-----------eNMEKAILAV 270 Thermococcus chitonophagus
KUK01605  219 lqengikvkRRRISLrgdt-------vgvPDRINLILEILLKMIfe----------dkKMEEAILEV 268 Methanobacteriaceae archaeon 41...
CEF98121  605 sa----rleTRRLPIrehrp----dqthtVLNIDAVVKILCARHrg-----------eSWTEVFERE 652 Ostreococcus tauri
CCO15853  733 sl----gvqSRKLPVktlrp----dqthdVLNIDTVVKILRSAWtmderqedddekkgGFHRAFDEV 791 Bathycoccus prasinos
ACO61137  830 al----gacARRLPVrehlp----lvtnqILNIDTAMKVLCERYsg-----------kEWGDALRAA 877 Micromonas sp. RCC299
EEY65902  180 rg-----irTARLPLqehfeqlgsrvrthIMNLDSVLIVLNEVAnh-----------gDWKRAFERA 230 Phytophthora infestans T30-4
EZG45076  207 lq-----acCRRLPIkelam-----smnpILNINTVAEILADVKfn----------gaTINDAIVRA 253 Gregarina niphandrodes
AFZ81369  159 yg-----itCKSLPVkkyfp----eckkvVLNVSTVFEILMHKInn-----------lSWEDALNRC 205 Babesia equi strain WA

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