2NRY,3UIM,2OID


Conserved Protein Domain Family
STKc_IRAK

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cd14066: STKc_IRAK 
Click on image for an interactive view with Cn3D
Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRAKs are involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways, and are thus critical in regulating innate immune responses and inflammation. Some IRAKs may also play roles in T- and B-cell signaling, and adaptive immunity. Vertebrates contain four IRAKs (IRAK-1, -2, -3 (or -M), and -4) that display distinct functions and patterns of expression and subcellular distribution, and can differentially mediate TLR signaling. IRAK-1, -2, and -4 are ubiquitously expressed and are active kinases, while IRAK-M is only induced in monocytes and macrophages and is an inactive kinase. Variations in IRAK genes are linked to diverse diseases including infection, sepsis, cancer, and autoimmune diseases. IRAKs contain an N-terminal Death domain (DD), a proST region (rich in serines, prolines, and threonines), a central kinase domain (a pseudokinase domain in the case of IRAK3), and a C-terminal domain; IRAK-4 lacks the C-terminal domain. This subfamily includes plant receptor-like kinases (RLKs) including Arabidopsis thaliana BAK1 and CLAVATA1 (CLV1). BAK1 functions in BR (brassinosteroid)-regulated plant development and in pathways involved in plant resistance to pathogen infection and herbivore attack. CLV1, directly binds small signaling peptides, CLAVATA3 (CLV3) and CLAVATA3/EMBRYO SURROUNDING REGI0N (CLE), to restrict stem cell proliferation: the CLV3-CLV1-WUS (WUSCHEL) module influences stem cell maintenance in the shoot apical meristem, and the CLE40 (CLAVATA3/EMBRYO SURROUNDING REGION40) -ACR4 (CRINKLY4) -CLV1- WOX5 (WUSCHEL-RELATED HOMEOBOX5) module at the root apical meristem. The IRAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 270968
Aligned: 23 rows
Threshold Bit Score: 266.831
Created: 5-Jul-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:

cd14066 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd14066 is a member of the superfamily cl21453
Sub-family Hierarchy
cd13968PKc_likecd00142PI3Kc_likecd00891PI3Kccd00896PI3Kc_IIIcd05165PI3Kc_Icd00894PI3Kc_IB_gammacd05173PI3Kc_IA_betacd05174PI3Kc_IA_deltacd05175PI3Kc_IA_alphacd05166PI3Kc_IIcd00895PI3Kc_C2_betacd05176PI3Kc_C2_alphacd05177PI3Kc_C2_gammacd00893PI4Kc_IIIcd05167PI4Kc_III_alphacd05168PI4Kc_III_betacd05164PIKKccd00892PIKKc_ATRcd05163PIKK_TRRAPcd05169PIKKc_TORcd05170PIKKc_SMG1cd05171PIKKc_ATMcd05172PIKKc_DNA-PKcd00180PKccd00192PTKccd05032PTKc_InsR_likecd05061PTKc_InsRcd05062PTKc_IGF-1Rcd05033PTKc_EphRcd05063PTKc_EphR_A2cd05064PTKc_EphR_A10cd05065PTKc_EphR_Bcd05066PTKc_EphR_Acd05034PTKc_Src_likecd05067PTKc_Lck_Blkcd05068PTKc_Frk_likecd05072PTKc_Lyncd05073PTKc_Hckcd05148PTKc_Srm_Brkcd14203PTKc_Src_Fyn_likecd05069PTKc_Yescd05070PTKc_Fyncd05071PTKc_Srccd05035PTKc_TAMcd05074PTKc_Tyro3cd05075PTKc_Axlcd14204PTKc_Mercd05036PTKc_ALK_LTKcd05038PTKc_Jak_rpt2cd05079PTKc_Jak1_rpt2cd05080PTKc_Tyk2_rpt2cd05081PTKc_Jak3_rpt2cd14205PTKc_Jak2_rpt2cd05039PTKc_Csk_likecd05082PTKc_Cskcd05083PTKc_Chkcd05040PTKc_Ack_likecd05041PTKc_Fes_likecd05084PTKc_Fescd05085PTKc_Fercd05042PTKc_Aatykcd05086PTKc_Aatyk2cd05087PTKc_Aatyk1cd14206PTKc_Aatyk3cd05043PTK_Rykcd05044PTKc_c-roscd05045PTKc_RETcd05046PTK_CCK4cd05047PTKc_Tiecd05088PTKc_Tie2cd05089PTKc_Tie1cd05048PTKc_Rorcd05090PTKc_Ror1cd05091PTKc_Ror2cd05049PTKc_Trkcd05092PTKc_TrkAcd05093PTKc_TrkBcd05094PTKc_TrkCcd05050PTKc_Muskcd05051PTKc_DDRcd05095PTKc_DDR2cd05096PTKc_DDR1cd05097PTKc_DDR_likecd05052PTKc_Ablcd05053PTKc_FGFRcd05098PTKc_FGFR1cd05099PTKc_FGFR4cd05100PTKc_FGFR3cd05101PTKc_FGFR2cd05054PTKc_VEGFRcd05102PTKc_VEGFR3cd05103PTKc_VEGFR2cd14207PTKc_VEGFR1cd05055PTKc_PDGFRcd05104PTKc_Kitcd05105PTKc_PDGFR_alphacd05106PTKc_CSF-1Rcd05107PTKc_PDGFR_betacd05056PTKc_FAKcd05057PTKc_EGFR_likecd05108PTKc_EGFRcd05109PTKc_HER2cd05110PTKc_HER4cd05111PTK_HER3cd05058PTKc_Met_Roncd05059PTKc_Tec_likecd05112PTKc_Itkcd05113PTKc_Btk_Bmxcd05114PTKc_Tec_Rlkcd05060PTKc_Syk_likecd05115PTKc_Zap-70cd05116PTKc_Sykcd05037PTK_Jak_rpt1cd05076PTK_Tyk2_rpt1cd05077PTK_Jak1_rpt1cd05078PTK_Jak2_rpt1cd14208PTK_Jak3_rpt1cd05117STKc_CAMKcd14082STKc_PKDcd14083STKc_CaMKIcd14166STKc_CaMKI_gammacd14167STKc_CaMKI_alphacd14168STKc_CaMKI_deltacd14169STKc_CaMKI_betacd14084STKc_Chk2cd14085STKc_CaMKIVcd14086STKc_CaMKIIcd14087STKc_PSKH1cd14088STKc_CaMK_likecd14089STKc_MAPKAPKcd14170STKc_MAPKAPK2cd14171STKc_MAPKAPK5cd14172STKc_MAPKAPK3cd14090STKc_Mnkcd14173STKc_Mnk2cd14174STKc_Mnk1cd14091STKc_RSK_Ccd14175STKc_RSK1_Ccd14176STKc_RSK2_Ccd14177STKc_RSK4_Ccd14178STKc_RSK3_Ccd14092STKc_MSK_Ccd14179STKc_MSK1_Ccd14180STKc_MSK2_Ccd14093STKc_PhKGcd14181STKc_PhKG2cd14182STKc_PhKG1cd14094STKc_CASKcd14095STKc_DCKLcd14183STKc_DCKL1cd14184STKc_DCKL2cd14185STKc_DCKL3cd14096STKc_RCK1-likecd14097STKc_STK33cd14098STKc_Rad53_Cds1cd05118STKc_CMGCcd07829STKc_CDK_likecd07835STKc_CDK1_CdkB_likecd07837STKc_CdkB_plantcd07860STKc_CDK2_3cd07861STKc_CDK1_eukcd07836STKc_Pho85cd07838STKc_CDK4_6_likecd07862STKc_CDK6cd07863STKc_CDK4cd07839STKc_CDK5cd07840STKc_CDK9_likecd07864STKc_CDK12cd07865STKc_CDK9cd07866STKc_BUR1cd07841STKc_CDK7cd07842STKc_CDK8_likecd07867STKc_CDC2L6cd07868STKc_CDK8cd07843STKc_CDC2L1cd07844STKc_PCTAIRE_likecd07869STKc_PFTAIRE1cd07870STKc_PFTAIRE2cd07871STKc_PCTAIRE3cd07872STKc_PCTAIRE2cd07873STKc_PCTAIRE1cd07845STKc_CDK10cd07830STKc_MAK_likecd07831STKc_MOKcd07832STKc_CCRKcd07833STKc_CDKLcd07846STKc_CDKL2_3cd07847STKc_CDKL1_4cd07848STKc_CDKL5cd07834STKc_MAPKcd07849STKc_ERK1_2_likecd07850STKc_JNKcd07874STKc_JNK3cd07875STKc_JNK1cd07876STKc_JNK2cd07851STKc_p38cd07877STKc_p38alphacd07878STKc_p38betacd07879STKc_p38deltacd07880STKc_p38gammacd07852STKc_MAPK15-likecd07853STKc_NLKcd07854STKc_MAPK4_6cd07855STKc_ERK5cd07856STKc_Sty1_Hog1cd07857STKc_MPK1cd07858STKc_TEY_MAPKcd07859STKc_TDY_MAPKcd14132STKc_CK2_alphacd14133PKc_DYRK_likecd14210PKc_DYRKcd14224PKc_DYRK2_3cd14225PKc_DYRK4cd14226PKc_DYRK1cd14211STKc_HIPKcd14227STKc_HIPK2cd14228STKc_HIPK1cd14229STKc_HIPK3cd14212PKc_YAK1cd14134PKc_CLKcd14213PKc_CLK1_4cd14214PKc_CLK3cd14215PKc_CLK2cd14135STKc_PRP4cd14136STKc_SRPKcd14216STKc_SRPK1cd14217STKc_SRPK2cd14218STKc_SRPK3cd14137STKc_GSK3cd05122PKc_STEcd06605PKc_MAPKKcd06615PKc_MEKcd06649PKc_MEK2cd06650PKc_MEK1cd06616PKc_MKK4cd06617PKc_MKK3_6cd06618PKc_MKK7cd06619PKc_MKK5cd06620PKc_Byr1_likecd06621PKc_Pek1_likecd06622PKc_PBS2_likecd06623PKc_MAPKK_plant_likecd06606STKc_MAPKKKcd06624STKc_ASKcd06625STKc_MEKK3_likecd06651STKc_MEKK3cd06652STKc_MEKK2cd06653STKc_MEKK3_like_u1cd06626STKc_MEKK4cd06627STKc_Cdc7_likecd06628STKc_Byr2_likecd06629STKc_Bck1_likecd06630STKc_MEKK1cd06631STKc_YSK4cd06632STKc_MEKK1_plantcd06607STKc_TAOcd06633STKc_TAO3cd06634STKc_TAO2cd06635STKc_TAO1cd06608STKc_myosinIII_N_likecd06636STKc_MAP4K4_6_Ncd06637STKc_TNIKcd06638STKc_myosinIIIA_Ncd06639STKc_myosinIIIB_Ncd06609STKc_MST3_likecd06640STKc_MST4cd06641STKc_MST3cd06642STKc_STK25cd06917STKc_NAK1_likecd06610STKc_OSR1_SPAKcd06611STKc_SLK_likecd06643STKc_SLKcd06644STKc_STK10cd06612STKc_MST1_2cd06613STKc_MAP4K3_likecd06645STKc_MAP4K3cd06646STKc_MAP4K5cd06614STKc_PAKcd06647STKc_PAK_Icd06654STKc_PAK1cd06655STKc_PAK2cd06656STKc_PAK3cd06648STKc_PAK_IIcd06657STKc_PAK4cd06658STKc_PAK5cd06659STKc_PAK6cd14131PKc_Mps1cd05123STKc_AGCcd05570STKc_PKCcd05587STKc_cPKCcd05615STKc_cPKC_alphacd05616STKc_cPKC_betacd05588STKc_aPKCcd05617STKc_aPKC_zetacd05618STKc_aPKC_iotacd05589STKc_PKNcd05590STKc_nPKC_etacd05591STKc_nPKC_epsiloncd05592STKc_nPKC_theta_likecd05619STKc_nPKC_thetacd05620STKc_nPKC_deltacd05571STKc_PKBcd05593STKc_PKB_gammacd05594STKc_PKB_alphacd05595STKc_PKB_betacd05572STKc_cGKcd05573STKc_ROCK_NDR_likecd05596STKc_ROCKcd05621STKc_ROCK2cd05622STKc_ROCK1cd05597STKc_DMPK_likecd05623STKc_MRCK_alphacd05624STKc_MRCK_betacd05598STKc_LATScd05625STKc_LATS1cd05626STKc_LATS2cd05599STKc_NDR_likecd05627STKc_NDR2cd05628STKc_NDR1cd05629STKc_NDR_like_fungalcd05600STKc_Sid2p_likecd05601STKc_CRIKcd05574STKc_phototropin_likecd05575STKc_SGKcd05602STKc_SGK1cd05603STKc_SGK2cd05604STKc_SGK3cd05576STKc_RPK118_likecd05577STKc_GRKcd05605STKc_GRK4_likecd05630STKc_GRK6cd05631STKc_GRK4cd05632STKc_GRK5cd05606STKc_beta_ARKcd05633STKc_GRK3cd14223STKc_GRK2cd05607STKc_GRK7cd05608STKc_GRK1cd05578STKc_Yank1cd05579STKc_MAST_likecd05609STKc_MASTcd05610STKc_MASTLcd05611STKc_Rim15_likecd05580STKc_PKA_likecd05612STKc_PRKX_likecd14209STKc_PKAcd05581STKc_PDK1cd05582STKc_RSK_Ncd05583STKc_MSK_Ncd05613STKc_MSK1_Ncd05614STKc_MSK2_Ncd05584STKc_p70S6Kcd05585STKc_YPK1_likecd05586STKc_Sck1_likecd08215STKc_Nekcd08217STKc_Nek2cd08218STKc_Nek1cd08219STKc_Nek3cd08220STKc_Nek8cd08221STKc_Nek9cd08222STKc_Nek11cd08223STKc_Nek4cd08224STKc_Nek6_7cd08228STKc_Nek6cd08229STKc_Nek7cd08225STKc_Nek5cd08528STKc_Nek10cd08529STKc_FA2-likecd08530STKc_CNK2-likecd08216PK_STRADcd08226PK_STRAD_betacd08227PK_STRAD_alphacd13973PK_MviN-likecd13974STKc_SHIKcd13975PKc_Dustycd13976PK_TRBcd14022PK_TRB2cd14023PK_TRB1cd14024PK_TRB3cd13977STKc_PDIK1Lcd13978STKc_RIPcd14025STKc_RIP4_likecd14026STKc_RIP2cd14027STKc_RIP1cd13979STKc_Moscd13980STKc_Vps15cd13981STKc_Bub1_BubR1cd14028STKc_Bub1_vertcd14029STKc_BubR1_vertcd13982STKc_IRE1cd13983STKc_WNKcd14030STKc_WNK1cd14031STKc_WNK3cd14032STKc_WNK2_likecd14033STKc_WNK4cd13984PK_NRBP1_likecd14034PK_NRBP1cd14035PK_MADMLcd13985STKc_GAK_likecd14036STKc_GAKcd14037STKc_NAK_likecd13986STKc_16cd13987STKc_SBK1cd13988STKc_TBK1cd13989STKc_IKKcd14038STKc_IKK_betacd14039STKc_IKK_alphacd13990STKc_TLKcd14040STKc_TLK1cd14041STKc_TLK2cd13991STKc_NIKcd13992PK_GCcd14042PK_GC-A_Bcd14043PK_GC-2Dcd14044PK_GC-Ccd14045PK_GC_unkcd13993STKc_Pat1_likecd13994STKc_HAL4_likecd13995STKc_MAP3K8cd13996STKc_EIF2AKcd14046STKc_EIF2AK4_GCN2_rpt2cd14047STKc_EIF2AK2_PKRcd14048STKc_EIF2AK3_PERKcd14049STKc_EIF2AK1_HRIcd13997PKc_Wee1_likecd14050PKc_Myt1cd14051PTKc_Wee1cd14138PTKc_Wee1acd14139PTKc_Wee1bcd14052PTKc_Wee1_fungicd13998STKc_TGFbR-likecd14053STKc_ACVR2cd14140STKc_ACVR2bcd14141STKc_ACVR2acd14054STKc_BMPR2_AMHR2cd14055STKc_TGFbR2_likecd14056STKc_TGFbR_Icd14142STKc_ACVR1_ALK1cd14143STKc_TGFbR1_ACVR1b_ACVR1ccd14144STKc_BMPR1cd14219STKc_BMPR1bcd14220STKc_BMPR1acd13999STKc_MAP3K-likecd14057PK_ILKcd14058STKc_TAK1cd14059STKc_MAP3K12_13cd14060STKc_MLTKcd14061STKc_MLKcd14145STKc_MLK1cd14146STKc_MLK4cd14147STKc_MLK3cd14148STKc_MLK2cd14062STKc_Rafcd14149STKc_C-Rafcd14150STKc_A-Rafcd14151STKc_B-Rafcd14063PK_KSRcd14152STKc_KSR1cd14153PK_KSR2cd14064PKc_TNNI3Kcd14065PKc_LIMK_likecd14154STKc_LIMKcd14221STKc_LIMK1cd14222STKc_LIMK2cd14155PKc_TESKcd14156PKc_LIMK_like_unkcd14066STKc_IRAKcd14157STKc_IRAK2cd14158STKc_IRAK4cd14159STKc_IRAK1cd14160PK_IRAK3cd14664STK_BAK1_likecd14000STKc_LRRKcd14067STKc_LRRK1cd14068STKc_LRRK2cd14001PKc_TOPKcd14002STKc_STK36cd14003STKc_AMPK-likecd14069STKc_Chk1cd14070STKc_HUNKcd14071STKc_SIKcd14072STKc_MARKcd14073STKc_NUAKcd14161STKc_NUAK2cd14074STKc_SNRKcd14075STKc_NIM1cd14076STKc_Kin4cd14077STKc_Kin1_2cd14078STKc_MELKcd14079STKc_AMPK_alphacd14080STKc_TSSK-likecd14162STKc_TSSK4-likecd14163STKc_TSSK3-likecd14164STKc_TSSK6-likecd14165STKc_TSSK1_2-likecd14081STKc_BRSK1_2cd14662STKc_SnRK2cd14665STKc_SnRK2-3cd14663STKc_SnRK3cd14004STKc_PASKcd14005STKc_PIMcd14100STKc_PIM1cd14101STKc_PIM2cd14102STKc_PIM3cd14006STKc_MLCK-likecd14103STKc_MLCKcd14190STKc_MLCK2cd14191STKc_MLCK1cd14192STKc_MLCK3cd14193STKc_MLCK4cd14104STKc_Titincd14105STKc_DAPKcd14194STKc_DAPK1cd14195STKc_DAPK3cd14196STKc_DAPK2cd14106STKc_DRAKcd14197STKc_DRAK1cd14198STKc_DRAK2cd14107STKc_obscurin_rpt1cd14108STKc_SPEG_rpt1cd14109PK_Unc-89_rpt1cd14110STKc_obscurin_rpt2cd14111STKc_SPEG_rpt2cd14112STKc_Unc-89_rpt2cd14113STKc_Trio_Ccd14114STKc_Twitchin_likecd14115STKc_Kalirin_Ccd14007STKc_Auroracd14116STKc_Aurora-Acd14117STKc_Aurora-B_likecd14008STKc_LKB1_CaMKKcd14118STKc_CAMKKcd14199STKc_CaMKK2cd14200STKc_CaMKK1cd14119STKc_LKB1cd14009STKc_ATG1_ULK_likecd14120STKc_ULK1_2-likecd14201STKc_ULK2cd14202STKc_ULK1cd14121STKc_ULK3cd14010STKc_ULK4cd14011PK_SCY1_likecd14012PK_eIF2AK_GCN2_rpt1cd14013STKc_SNT7_plantcd14014STKc_PknB_likecd14015STKc_VRKcd14122STKc_VRK1cd14123STKc_VRK2cd14124PK_VRK3cd14016STKc_CK1cd14125STKc_CK1_delta_epsiloncd14126STKc_CK1_gammacd14127STKc_CK1_fungalcd14128STKc_CK1_alphacd14017STKc_TTBKcd14129STKc_TTBK2cd14130STKc_TTBK1cd14018STKc_PINK1cd14019STKc_Cdc7cd14020STKc_KIScd14099STKc_PLKcd14186STKc_PLK4cd14187STKc_PLK1cd14188STKc_PLK2cd14189STKc_PLK3cd05119RIOcd05144RIO2_Ccd05145RIO1_likecd05146RIO3_eukcd05147RIO1_eukcd05120APH_ChoK_likecd05150APHcd05151ChoK-likecd14021ChoK-like_eukcd05156ChoK_eukcd05157ETNK_eukcd05152MPH2'cd05153HomoserineK_IIcd05154ACAD10_11_N-likecd05155APH_ChoK_like_1cd05121ABC1_ADCK3-likecd13969ADCK1-likecd13970ABC1_ADCK3cd13971ADCK2-likecd13972UbiBcd05124AFK
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1     #####   #            # #                                     #                 #
2NRY_A     39 MGEGGFGVVYKGYVn--NTTVAVKKLAAmvdi---tteeLKQQFDQEIKVMAKCq--HENLVELLGFSSdg--dDLCLVY 109 human
2OID_A     33 MGEGGFGVVYKGYVn--NTTVAVKKLAAmvdi---tteeLKQQFDQEIKVMAKCq--HENLVELLGFSSdg--dDLCLVY 103 human
P51617    218 IGEGGFGCVYRAVMr--NTVYAVKRLKEnadl---ewtaVKQSFLTEVEQLSRFr--HPNIVDFAGYCAqn--gFYCLVY 288 human
NP_973956  49 IGTGGYSSIYLARVs--GSINAALKVHVss-------hrLYQVFRSELEILLRLq--HPHIVKLLGYFDds--eSGALLL 115 thale cress
NP_567053  55 ISSWGYFIWYKGVIe--ERQVSIKKWSSqn-------lsSFTEAYRDISVSSQMs-gHKNALKLIGCCLef--dLPALVC 122 thale cress
AAK37545  191 IGKGGYGTVYKGELkgtGGIVAVKRLHSgndtsqngsreRLRQSLTELRTLARFr--HDNILPIYAYSLeg--sEPCLVY 266 nematode
Q05652    219 LGQGGFGDVYRGKWk--QLDVAIKVMNYrspni-dqkmvELQQSYNELKYLNSIr--HDNILALYGYSIkg--gKPCLVY 291 fruit fly
NP_180839 538 VAEVDFGTAYYGLLn-gDQHIVVKRLGMtkc------paLVTRFSTELLNLGRLr--HRNLVMLRGWCTeh--gEMLVVY 606 thale cress
ABA94280  349 LATGSSYNIYKGTLe-dNTLVAVKKYFDry-------eaGKEEFRSRVAMVIMSpvvHKNITKLLGICLea--nPPTLVY 418 Japanese rice
NP_182059 423 LGKSNVSSVYKGILr-dGSVAAIKCIAKssc------ksDESEFLKGLKMLTLLk--HENLARLRGFCCskgrgECFLIY 493 thale cress
Feature 1     ###   #                                                 # # ## #          #     
2NRY_A    110 VYMpNGSLLDRLScld---gtPPLSWHMRCKIAQGAANGINFLHE-----NHHIHRDIKSANILLDeaFTAKISDFGLAR 181 human
2OID_A    104 VYMpNGSLLDRLScld---gtPPLSWHMRCKIAQGAANGINFLHE-----NHHIHRDIKSANILLDeaFTAKISDFGLAR 175 human
P51617    289 GFLpNGSLEDRLHcqt--qacPPLSWPQRLDILLGTARAIQFLHQd---sPSLIHGDIKSSNVLLDerLTPKLGDFGLAR 363 human
NP_973956 116 EYLpQGNLQEKLNrn----skQVLPWRNRTAIAFQVAQAIEHIHEkc--sPQIVHGDIKSSNILLDkhFNSKLCDFGSAK 189 thale cress
NP_567053 123 EYTeHGPLNRDGGls----sgVVLPWKVRLKIAKEIASSVTYLHTaf--pETIVHRNINPTNIFIDenWTAKLSDFWFCV 196 thale cress
AAK37545  267 QFMsNGSLEDRLLcrk---gsVPLTWIQRKEISIGAGRGLGFLHSfg--kTPIIHGDIKTANILLDkhMEPKIGDFGLCR 341 nematode
Q05652    292 QLMkGGSLEARLRahkaqnplPALTWQQRFSISLGTARGIYFLHTar--gTPLIHGDIKPANILLDqcLQPKIGDFGLVR 369 fruit fly
NP_180839 607 DYSaNRKLSHLLFhnhi-pgnSVLRWKSRYNVIKSLACAVRYLHEew--dEQVIHRNITSSTIFLDrdMNPRLCGFALAE 683 thale cress
ABA94280  419 EYA-ARNLSDILHc------kEDFPLELRLKIASKTSRVLEHLHSs---rIALRHGDVMPSNILLDdgFVPKVTAFTLST 488 Japanese rice
NP_182059 494 EFVpNGNLLQYLDvkd--etgEVLEWATRVSIINGIARGIVYLHGengnkPAIVHQNLSAEKILIDhwYNPSLADSGLHK 571 thale cress
Feature 1                                                                                     
2NRY_A    182 ASekfaq-----------tvmxSRIVGTTAYMAPEALrg-eiTPKSDIYSFGVVLLEIItGLPAVDEhrep----qllLD 245 human
2OID_A    176 ASekfaq-----------xvmxXRIVGTTAYMAPEALrg-eiTPKSDIYSFGVVLLEIItGLPAVDEhrep----qllLD 239 human
P51617    364 FSrfagssps----qssmvartQTVRGTLAYLPEEYIktgrlAVDTDTFSFGVVVLETLaGQRAVKThga------rtKY 433 human
NP_973956 190 VGfssmvqpskttstmsprskqVMMIGSPGYTDPHYLrtgiaSKKMDMYGFGVVVLELVsGKEAVSSergemlvhstaSL 269 thale cress
NP_567053 197 AIpege------------lyveDDVKGVIGFVDPDYYwtmkvTEKVDIYSFGVVMLVLLsGRAAVFNgpdea--pmslND 262 thale cress
AAK37545  342 DGhveaeam------ekhpliaSHIKGTLAYLAPEFItskilTTKLDVYSFGIVLLEIAsGQRAYSDsr-------etRG 408 nematode
Q05652    370 EGpksld----------avvevNKVFGTKIYLPPEFRnfrqlSTGVDVYSFGIVLLEVFtGRQVTDRvpen----etkKN 435 fruit fly
NP_180839 684 FLsrndkah-------qaakkkGSAQGIFGYMAPEYMesgeaTTMADVYSFGVVVLEMVtGQPAVDYkrkke-dalmvLR 755 thale cress
ABA94280  489 RFtedn------------atrmSMVKGDGNYMDPYYRhtnlvLLKSDVYSFGVVLLELItRKQPAGDcp-------ekYG 549 Japanese rice
NP_182059 572 LFtddi------------vfskLKASAAMGYLAPEYIttgrfTDKSDVYAFGMILLQILsGKSKISH-----------LM 628 thale cress
Feature 1                                                                                     
2NRY_A    246 IKEEIEdeek-----------------------------tieDYIDKKMNDad---------stSVEAMYSVASQCLHek 287 human
2OID_A    240 IKEEIEdeek-----------------------------tieDYIDKKMNDad---------stSVEAMYSVASQCLHek 281 human
P51617    434 LKDLVEeeaeeagvalrstqstlqaglaadawaapiamqiykKHLDPRPGPcp---------peLGLGLGQLACCCLHrr 504 human
NP_973956 270 IHEILDsngdig-------------------------eekvrQFLDPRLSRdgsi------dleEVKTMLRVAAFCLRsp 318 thale cress
NP_567053 263 HVSEVMekg------------------------------efdEIVDKEIWNdlggdddlvlrrsQVKAFLRLALRCVRy- 311 thale cress
AAK37545  409 LVEYCQvnkelaah---------------------rkipvreIFIDRRAPPlvgd-----eeksFLDALIEVGLAGANnd 462 nematode
Q05652    436 LLDYVKqqwr----------------------------qnrmELLEKHLAApmgk------eldMCMCAIEAGLHCTAld 481 fruit fly
NP_180839 756 IREVVGnrkk-----------------------------lleEIADIHLDDeye--------nrELARLLRLGLVCTRtd 798 thale cress
ABA94280  550 LVSEFAraykm--------------------------nksgkAMFDERIATeen--------ipVLEEIGKLALHCINlk 595 Japanese rice
NP_182059 629 ILQAVEsgr------------------------------lneDFMDPNLRKnfp--------evEAAQLARLGLLCTHes 670 thale cress
Feature 1                        
2NRY_A    288 KNKRPDIK--KVQQLLQEM 304 human
2OID_A    282 KNKRPDIK--KVQQLLQEM 298 human
P51617    505 AKRRPPMT--QVYERLEKL 521 human
NP_973956 319 PSLRPSAS--QVVQTLNKK 335 thale cress
NP_567053 312 KKEDPVSGmlEVAKELKLI 330 thale cress
AAK37545  463 RKVRPTMS--QIVEYLCKN 479 nematode
Q05652    482 PQDRPSMN--AVLKRFEPF 498 fruit fly
NP_180839 799 PKLRPSIS--QVVSILDGS 815 thale cress
ABA94280  596 LSKRPTMK--EVAERLKKI 612 Japanese rice
NP_182059 671 SNQRPSME--DVIQELNNL 687 thale cress

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