Conserved Protein Domain Family
CYP71-like

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cd11072: CYP71-like 
cytochrome P450 family 71 and similar cytochrome P450s
The group includes plant cytochrome P450 family 71 (CYP71) proteins, as well as some CYPs designated as belonging to a different family including CYP99A1, CYP83B1, and CYP84A1, among others. Characterized CYP71 enzymes include: parsnip (Pastinaca sativa) CYP71AJ4, also called angelicin synthase, that converts (+)-columbianetin to angelicin, an angular furanocumarin; periwinkle (Catharanthus roseus) CYP71D351, also called tabersonine 16-hydroxylase 2, that is involved in the foliar biosynthesis of vindoline; sorghum CYP71E1, also called 4-hydroxyphenylacetaldehyde oxime monooxygenase, that catalyzes the conversion of p-hydroxyphenylacetaldoxime to p-hydroxymandelonitrile; as well as maize CYP71C1, CYP71C2, and CYP71C4, which are monooxygenases catalyzing the oxidation of 3-hydroxyindolin-2-one, indolin-2-one, and indole, respectively. CYPs within a single CYP71 subfamily, such as the C subfamily, usually metabolize similar/related compounds. The CYP71-like family belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410695
Aligned: 151 rows
Threshold Bit Score: 507
Created: 11-Feb-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
heme bindingputative
Feature 1:heme binding site [chemical binding site]
Evidence:
  • Comment:based on the structure of Salvia miltiorrhiza CYP76AH1 with bound heme (5YM3), defined at 4A contacts

cd11072 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd11072 is a member of the superfamily cl41757
cd11072 Sequence Cluster
Sub-family Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                          #                        #   #       #     
Q9STL2     62 RYGPLMLLHLGrvPVLVVSSADVARDILKTHDRVFASRPrsklfeklfydgrdvaFAPYGEYWRQIKSVCVLRLLsnkmv 141 thale cress
W8JDE2     73 KYGPIMHLRIGqlSAVIISSAEKAKEILNTHGVRVADRPqttvakimlynslgvtFAPYGDYLKQLRQIYAMELLspktv 152 Madagascar periwinkle
G3GBK0     61 KYGPIMHLQLGqvSTVVVSTPRLAREIMKTNDISFADRPttttsqiffykaqdigWAPYGEYWRQMKKICTLELLsakkv 140 chicory
F8S1H3     59 KYGPIMHLRLGqvSTVVISSPRLAHEIMKTQDLSFADRPttttsqiffykasniaWARYGNYWRQMKKICTLELLsakks 138 common sunflower
Q6IV13     65 KYGPVTHVQLGevFSVVLSSREATKEAMKLLDPACADRFesigtrimwydnddiiFSPYSDHWRQMRKICVSELLsarnv 144 spearmint
Q6WKZ1     65 KYGPVAHVQLGevYSVVLSSAEAAKQAMKVLDPNFADRFdgigsrtmwydkddiiFSPYNDHWRQMRRICVTELLspknv 144 Scotch spearmint
Q9XHE6     66 EYGPVAHVQLGevFSVVLSSREATKEAMKLVDPACANRFesigtrimwydnediiFSPYSEHWRQMRKICVSELLssrnv 145 peppermint
Q6WKZ0     63 EYGPVAHVQLGevYSVVLSSAEAAKQAMKVLDPNFADRFdsvgsrimwydnddiiFSPYNDHWHQMRKICVSELLspknv 142 Scotch spearmint
P0DO14     64 KYGPIMHLQFGevSAIIVSSAKLAKVFLGNHGLAVADRPktmvatimlynssgvtFAPYGDYWKHLRQVYAVELLspksv 143 Gelsemium sempervi...
I1TEM0     64 KHGPLMHVKMGerSAIIVSDARMAKIVLHNNGLAVADRSvntvasimtynslgvtFAQYGDYLTKLRQIYTLELLsqkkv 143 Madagascar periwinkle
Feature 1                                             #                                       
Q9STL2    142 tsFRNVRQEEISLMMEKIQkssslq-vnvseLLGSLTNDVISRIALGrkysGETDSKELMKRLMMLMGef-sVGTYVPWL 219 thale cress
W8JDE2    153 ksFWTIMDDELSTMITSIKsevgqp-milhdKMMTYLYAMLCRATVGsvcnGRETLIMAAKETSALSAsi-rIEDLFPSV 230 Madagascar periwinkle
G3GBK0    141 rsFSSIREEELSRISKVLEsqagtp-infteMTVEMVNNVICKATLGdsckDQATLIEVLYDVLKTLSaf-nLASYYPGL 218 chicory
F8S1H3    139 rsFFYIREEELTRTYKFLDfssgtp-itlrdTIQEMVNNVVSRATLGdvseDRQFIIDSTYTMLKSFNsf-nLFNYYPSL 216 common sunflower
Q6IV13    145 rsFGFIRQDEMSRLLRHLQssaget-vdmteRIATLTCSIICRAAFGaiinDHEELVELVKDSLSMASgf-eLADLFPSS 222 spearmint
Q6WKZ1    145 rsFGYIRQEEIERLIRLLGssggap-vdvteEVSKMSCVVVCRAAFGsvlkDQGSLAELVKESLALASgf-eLADLYPSS 222 Scotch spearmint
Q9XHE6    146 rsFGFIRQDEVSRLLRHLRssagaa-vdmteRIETLTCSIICRAAFGsvirDNAELVGLVKDALSMASgf-eLADMFPSS 223 peppermint
Q6WKZ0    143 rsFGFIRQEEIERLIRVMKqsegap-vdvteEVSKMSCFVVCRAAFGsvlkDQGSLAELVKESLAMASgf-eLKDLYPSS 220 Scotch spearmint
P0DO14    144 rsFSMIMDEEISLMLKRIQsnaagqplkvhdEMMTYLFATLCRTSIGsvckGRDLLIDTAKDISAISAai-rIEELFPSL 222 Gelsemium sempervi...
I1TEM0    144 rsFYSCFEDELDTFVKSIKsnvgqp-mvlyeKASAYLYATICRTIFGsvckEKEKMIKIVKKTSLLSGtplrLEDLFPSM 222 Madagascar periwinkle
Feature 1                                                                                     
Q9STL2    220 GWIDWISglDGQLNKTGNDLDEFLEKVVQDHVDGDGQrtdfvdvllri-----------qreksigfeiDRLCIKAIVLD 288 thale cress
W8JDE2    231 KILPVISglKSKLTNLLKELDIVLEDIISAREKKLLSqpqqplmldeedmlgvllkykngkgndtkfrvTNNDIKAIVFE 310 Madagascar periwinkle
G3GBK0    219 QFLNVILgkKAKWLKMQKQLDDILEDVLKEHRSKGSNksdqedlvdvll--------rvkdtggldftvTDEHVKAVVLD 290 chicory
F8S1H3    217 SFINVISgkQAQWLKMHKEVDVILEKILREHRSRPRGkndhedlvdvli--------riketgdldmaiTDDNIKAIILE 288 common sunflower
Q6IV13    223 KLLNLLCwnKSKLWRMRRRVDTILEAIVDEHKLKKSGefggediidvlf--------rmqkdsqikvpiTTNAIKAFIFD 294 spearmint
Q6WKZ1    223 WLLNLLSlnKYRLQRMRRRLDHILDGFLEEHREKKSGefggedivdvlf--------rmqkgsdikipiTSNCIKGFIFD 294 Scotch spearmint
Q9XHE6    224 KLLNLLCwnKSKLWRMRRRVDTILEAIVDEHKFKKSGefggediidvlf--------rmqkdtqikvpiTTNSIKAFIFD 295 peppermint
Q6WKZ0    221 WLLNLLSfnNYRLKRMRRRLDHVLDGFLEEHRVKKNGefggedivdvlf--------rmqkdsnikipiTSNGIKGFIFN 292 Scotch spearmint
P0DO14    223 KILPYITglHRQLGKLSKRLDGILEDIIAQREKMQESstgdnderdilgvll---klkrsnsndtkvriRNDDIKAIVFE 299 Gelsemium sempervi...
I1TEM0    223 SIFCRFSktLNQLRGLLQEMDDILEEIIVEREKASEVskeakddedmlsvll---rhkwynpsgakfriTNADIKAIIFE 299 Madagascar periwinkle
Feature 1     #  ##  ##                                                          #   ## #     
Q9STL2    289 VLVAGTDSSYALMDWAMTELLRHPeCLRTLQEEVRTICKgnlsvseeDIQNMSYLKAVIKETTRLHPPlpLLAPHESIQD 368 thale cress
W8JDE2    311 LILAGTLSSAAIVEWCMSELMKNPeLLKKAQDEVRQVLKgkktisgsDVGKLEYVKMVVKESVRLHPPapLLFPRECREE 390 Madagascar periwinkle
G3GBK0    291 MLTAGTDTSSATLEWAMTELMRNPhMMKRAQDEVRSVVKgnti-tetDLQSLHYLKLIVKETLRLHAPtpLLVPRECRQD 369 chicory
F8S1H3    289 MLTAGTSSSSMTIEWAFTEMMRNPkIMKKAQTEVRSVVKgdrv-teaDIQNLDYTKLVIKETLRLHGVp-ILVPRENQED 366 common sunflower
Q6IV13    295 TFSAGTETSSTTTLWVMAELMRNPaVMAKAQAEVRAALKgktsvdvdDVQELKYMKSVVKETMRMHPPi-PLIPRSCREE 373 spearmint
Q6WKZ1    295 TFSAGAETSSTTISWALSELMRNPaKMAKVQAEVREALKgktvvdlsEVQELKYLRSVLKETLRLHPPf-PLIPRQSREE 373 Scotch spearmint
Q9XHE6    296 TFSAGTETSSTTTLWVLAELMRNPaVMAKAQAEVRAALKektnwdvdDVQELKYMKSVVKETMRMHPPi-PLIPRSCREE 374 peppermint
Q6WKZ0    293 TFSAGAEASSTTISWALSELMRNPaKMAKVQAEVREALKgktsvdlsEMQELKYMRSVVKETLRLHPPf-PLIPRQSREE 371 Scotch spearmint
P0DO14    300 LILAGTLSTAATVEWCLSELKKNPgAMKKAQDEVRQVMKgeti-ctnDVQKLEYIRMVIKETFRMHPPapLLFPRECREP 378 Gelsemium sempervi...
I1TEM0    300 LILAATLSVADVTEWAMVEILRDPkSLKKVYEEVRGICKekkrvtgyDVEKMEFMRLCVKESTRIHPAapLLVPRECRED 379 Madagascar periwinkle
Feature 1                                                            ####  #####  ##          
Q9STL2    369 VILgDYHIPAGTQVMINAWAIGREaatwgPDAEKFRPERHLdssvdfrghnFELVPFGAGRRICPAISFAVVLIEVALAN 448 thale cress
W8JDE2    391 FEIdGMTIPKKSWVIINYWAIGRDpk-iwPNADKFEPERFSnnnidfygsnFELIPFGAGRRVCPGILFGTTNVELLLAA 469 Madagascar periwinkle
G3GBK0    370 CNVdGYDIPAKTKILVNAWACGTDpd-swKDPESFIPERFEncpinymgadFEFIPFGAGRRICPGLTFGLSMVEYPLAN 448 chicory
F8S1H3    367 CVVnGYDIPAKTRLLVNAWACATDpd-swEDPDSFIPERFEnnsigysgadFEFIPFGAGRRICPGMNFGMGTVEYVVAN 445 common sunflower
Q6IV13    374 CEVnGYKIPNKARIMINVWSMGRNpl-ywEKPETFWPERFDqvsrdfmgsdFEFIPFGAGRRICPGLNFGLANVEVPLAQ 452 spearmint
Q6WKZ1    374 CEVnGYTIPAKTRIFINVWAIGRDpq-ywEDPDTFRPERFDevsrdfmgndFEFIPFGAGRRICPGLHFGLANVEIPLAQ 452 Scotch spearmint
Q9XHE6    375 CVVnGYTIPNKARIMINVWSMGRNpl-ywEKPDTFWPERFDqvskdfmgndFEFVPFGAGRRICPGLNFGLANVEVPLAQ 453 peppermint
Q6WKZ0    372 CEInGFYIPARTRILINAWSIGRDpl-ywEDPDTFRPERFDevsrdfmgndFEFIPFGAGQRICPGLHFGLANVEIPLAQ 450 Scotch spearmint
P0DO14    379 IQVeGYTIPEKSWLIVNYWAVGRDpe-lwNDPEKFEPERFRnspvdmsgnhYELIPFGAGRRICPGISFAATNAELLLAS 457 Gelsemium sempervi...
I1TEM0    380 FEVdGYTVPKGAWVITNCWAVQMDpt-vwPEPEKFDPERYIrnpmdfygsnFELIPFGTGRRGCPGILYGVTNAEFMLAA 458 Madagascar periwinkle
Feature 1                                       
Q9STL2    449 FVHRYDWklpedsKENQTNVAESTGmVIHRLFPL 482 thale cress
W8JDE2    470 FLFHFDWelpggmKPEELDMNELFGaGCIRENPL 503 Madagascar periwinkle
G3GBK0    449 FLYHFDWklpnglKPHELDITEITGiSTSLKHQL 482 chicory
F8S1H3    446 LLLHYDWklpdgmKPHDIDMREITGiSTLPIHPL 479 common sunflower
Q6IV13    453 LLYHFDWklaegmKPSDMDMSEAEGlTGIRKNNL 486 spearmint
Q6WKZ1    453 LLYHFDWklpqgmTDADLDMTETPGlSGPKKKNV 486 Scotch spearmint
Q9XHE6    454 LLYHFDWklaegmKPSDMDMSEAEGlTGILKNNL 487 peppermint
Q6WKZ0    451 LLYHFDWklpqgmTDADLYVAGTPGlSGPRKKNV 484 Scotch spearmint
P0DO14    458 LIYHFDWkl--paGVKELDMDELFGaGCVRKNPL 489 Gelsemium sempervirens
I1TEM0    459 MFYHFDWeiadgkKPEEIDLTEDFGaGCIMKYPL 492 Madagascar periwinkle

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