Conserved Protein Domain Family
NCA2

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pfam08637: NCA2 
ATP synthase regulation protein NCA2
NCA2 has been shown to be required for the regulation of ATP synthase subunits Atp6p and Atp8p in Saccharomyces cerevisiae.
Statistics
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Structure
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PubMed ReferencesClick to see Conserved Features Help

pfam08637 is the only member of the superfamily cl07311
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EGX52284      371 FLSSGTLLRLLVNRQEAIQMWIREAGETAYEFWDNWVVDPI----KRIISTIR-TGEDQEVAL-MSRESLISDRESLERM 444 
XP_003632255  310 WLLRHSSLM----GSNDIENWVREARDSTITFWNDHVEQPIlsirDELFETFRkRHRSV-----MELEDVQLTANSLHRM 380 
Q8GUK1        318 WLLRHSSLM----GSSDIENWVHDAKEATMSFFSDHVEQPLlsirDELFDTFRkRHKGV-----METEEVQLTQDSLHRM 388  thale cress
KRH73507      306 WLLRHSRLV----GSSDLDNWVQEARNSTYSFFRNHVEEPIfsirDELFDTFKkRHQGI-----MDVEEVQLTSNSLHRM 376 
XP_002523227  326 WLLRHSRFM----GSSDIDNWVREAKDSTVSFFSEHVEQPLvsirDELFDTFRkRHKGV-----MEIEEVQLTANSLHRM 396 
XP_002313474  326 WLLRHSRLM----GSPDIDNWVREAKDSTISFFNDHVEQPLlsirDELFDTFRkRHKGV-----MEVEEVQLTASSLHRM 396 
XP_004228479  311 WLLRHSSLV----GSSDIDNWIREAKESTASFWNDHVEQPLisirDDLFYTFRkRQKGA-----MEPEEVQLTADSLHRM 381 
ERM99085      190 WILRHSSLM----GSSDIDNWIREAKESTIGFWKDHVESPIlsirDELFETFRkRHKGM-----MELEEVQLTATSLHRM 260 
XP_009410420  316 WFLRHSSFM----GSPDIDNWIHEAKESAAGFLKDHVEQPLisirDELFETFRkRQKGV-----MEMEEVQLTADSLHRM 386 
CBJ27434     1846 vpvaVRSARYARSNREELGRITTEAATGVSSFFSDQLWQPCeairKQVF--FR------ERSElMDKDSLEDAETSLQNM 1917
EGX52284      445 VVEFAIDNpsaalenastpLTPAEIELIRENVKQGD-LTPVLRVYEQDMKKPIRGAVTGELLRSLLIQIQKTKVDVEVAV 523 
XP_003632255  381 LLTFSEQT---------------QGQKFPEHASDQQmLEIVMARYEKELMHPIQNLLKGELAHALLIQIQKLKLDIETAM 445 
Q8GUK1        389 LRNFCEQA---------------TREKVPDNASDQEmLEVVMNRYEKELVHPIHNLLSGELARGLLIQVQKLKLDIETAM 453  thale cress
KRH73507      377 LLAFSEQT---------------KGQKFPVNASDQEmMEIVMDRYEKELMHPIQNLLNGELVRAILIQVQKLKLDTETAM 441 
XP_002523227  397 LLAFSEQT---------------KGQKLPENASDQElLEIVMNRYEKELMHPIQNLLNGELARALLIQVQKLKLDIETAM 461 
XP_002313474  397 LLAFSEQT---------------KVQKFPEHASDQEmLEIVMDRYEQELTHPIQNLLKGELAHALLIQVQKLKLDIETAM 461 
XP_004228479  382 LQAFTEQT---------------KGEKAPPNATDQEmLEIVMMRYEKELMHPIQNLFSGELSRALLIQVQKLKLDIEEAM 446 
ERM99085      261 LLAFTEQI---------------KGYKLPENSSDQEmLEIVMARYEKELMHPIQNLMGGELARLFLIQIQKLKLDIETVM 325 
XP_009410420  387 LLAFCEQT---------------KSQKLPENIPDQEmLEIVMARYEKEVMHPLQNLLSGELARAMLIQIQKLKLDLETAM 451 
CBJ27434     1918 LHDFVYDD-----------KNNVPEDLREEAVAAMD-MSVVSRELEEETKYSIRGTVNGRIPRMLFIQATFLKKELLHSM 1985
EGX52284      524 SGIDNMLKSQQLLFGMLGLTPGVLIVVGTTR----WMRSAWG-GRN----GIKkgeAKGRMVRILRHIDRILST--SAAy 592 
XP_003632255  446 LELNQILRANEINFAILAALPAFFVSLLLIM----LVRAWVKqDTRaegrGRV---ARIQRRLLVVEVEKWIMQyqTCMn 518 
Q8GUK1        454 LELDQILRANEINFAILAALPAFFLSIVMLT----VLRTWLKkDSKaqgrGRI---ARIHRRLLVVEIEKRIMQyqSYIe 526  thale cress
KRH73507      442 LELNQILRANEINFAVLTALPAFFLSLLLMM----LVRGWFKqDTKaegrGRV---ARIQRRLLVIEVKKRIMQyqNYVd 514 
XP_002523227  462 LELDQILKANEINFAVLAALPAFFLSLSLLM----LVRAWFKrDTKaegkGRI---ARRQRRLLLVEVEKRIMQyqTFVd 534 
XP_002313474  462 LELDQILKANEINFAILAALPAFFLSLLLLM----LLRAWFKrDTRaegrGRI---ARRQRRLLLVEVEKGIAQyqTYVn 534 
XP_004228479  447 LELDQILRANEINFAILAALPAFFLSLIVIM----LVRAWLKqDKKaegrGRV---ARIQRRLLIVEVERKIMQleSCKe 519 
ERM99085      326 LELNQILRANEINLAVLAALPAFFMSVGLGM----LVRAWIKqDKGaegrGKV---ARIQRRLLLVDAEKQIMHfqICMd 398 
XP_009410420  452 LELDQILRANEINFAVLAALPAFFLSLVLLM----LVRAWVMqDKSaegrGRV---ARRQRRLLVVEVERRLVQfqTCMd 524 
CBJ27434     1986 QAIDELFQANQVTLRLISVIPAALLLFAVAKvsgpFVHAA---SSRrlepTTA---VHRSMRASLREIERLLTS--SRGf 2057
EGX52284      593 ratkgr--gpevhgERSSILTFKEHGLLLCEIHVLRQLAGYVL--PRGvVMKE-FLEDLEEMGNIRn-GVRAQRGVVERV 666 
XP_003632255  519 qgkek--------------daqcmFGMVLYSLDRLYRAVERHA---KAtGEWLcLRQDIVELAKPGl-DTASKLILTARM 580 
Q8GUK1        527 qgrdk--------------daetvFGLLIYSLERLYRVVEKPA---RAtDEWDlVKQDLIELGRPQq-QTSYKLTVTQRL 588  thale cress
KRH73507      515 qgler--------------daeymFGLALYSLDRLYHSVKWHA---EAtGEWErLREDIIDLAKPRl-QTSHKESVISHM 576 
XP_002523227  535 qglen--------------esqcmFGLMLCSLDRLFHAVERHA---KEtGEWQsLKQDIFDLGKPSi-QTTYKLVVTSRM 596 
XP_002313474  535 qglek--------------esqcmFGLVLHCLDRLFHAVEGHA---KAtGEWQwLRQDIIDLGKPRl-QTDYKLMVLSRM 596 
XP_004228479  520 qgqek--------------daqcmLGLALYYLDRLYCAVEGHA---RAtGEWIsLRQDIIDLAKPDl-QTAHKLRITSRM 581 
ERM99085      399 rgqee--------------galqsFGLMLLTLNLLYKVVERHA---REtGEWSsLRQDIIDLAKPGl-QTGYKLTITSRM 460 
XP_009410420  525 qgkee--------------darciYGMVLYSLDRLYKAAERHA---KEtGEWMsLQQDILDLAKPNl-ETIYKLTVTSRM 586 
CBJ27434     2058 vgshepvgeeaegfASRGLLQDEEMGKLALHMHELQTTLRQNAsrFDSrARRR-LEEDLTDLMARGrpTVSQQIAVVHRM 2136
EGX52284      667 RWAY 670 
XP_003632255  581 ERVY 584 
Q8GUK1        589 VTVY 592  thale cress
KRH73507      577 --VT 578 
XP_002523227  597 ERVY 600 
XP_002313474  597 ERVY 600 
XP_004228479  582 ERVY 585 
ERM99085      461 GRMY 464 
XP_009410420  587 GQMY 590 
CBJ27434     2137 QRSY 2140
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