Conserved Protein Domain Family
Glu_cyclase_2

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pfam05096: Glu_cyclase_2 
Glutamine cyclotransferase
This family of enzymes EC:2.3.2.5 catalyze the cyclization of free L-glutamine and N-terminal glutaminyl residues in proteins to pyroglutamate (5-oxoproline) and pyroglutamyl residues respectively. This family includes plant and bacterial enzymes and seems unrelated to the mammalian enzymes.
Statistics
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PSSM-Id: 428301
Aligned: 36 rows
Threshold Bit Score: 305.665
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002906452             8 LLLATC----LGISATGNGLPT-----------AVRLVTIHPHNVSAFTEGLVFD-DGALIESTGLNGASFIRKYKLsDL 71 
bsuwp:MCON_2478         20 LLAAAL----TAGSASADKVDIdsftsssiktySYRIVNSYPHDPNAFTQGLEYD-DGLLYEGTGGYGQSSLRRVDI-QT 93 
WP_014587468            22 ALLSAL----VAGCLGGPSVGMapp------vyGYRVVAAYPHDPEAFTQGLAFR-DGLLYEGTGLYGRSEIRETVL-ET 89  Metha...
Q01NY8                  10 LLIALA----CALCACGPASSGsai-----reySYEVVNTFPHDPNAFTEGLFYL-DGFLYESTGLEGQSSIRKVRL-ET 78  Candi...
Q9A519                  13 LAAAIG----LAAPVLAAPAPVg----------GYKVVKSYPHDTRAFTQGLLYR-DGFIFESTGLQGRSFIRKWNL-ET 76  Caulo...
PRJNA213647:NX02_03905   7 ALLAGA----LAQPAEAAQPPAqpk------vcGYTVERSFPHDADAFTQGLIYR-DGNLIESTGLVGQSTIRRVRI-AD 74 
Q5VRH1                  60 VVLAAAhpygYAPWLANAAPAAllrrpvsttfySFDLLREYPHDPYAFTQGLLYGgNDTFFESTGLYHRSSVRRVDL-KT 138 Japan...
NP_001305615            26 LIVLLI----FAVFSEAEASYGa---------yKVKVINEFPHDPEAYTQGLLYAeNDTLFESTGLYGRSSVRKVAL-QN 91 
XP_003533156            43 VVSVIA----LLVLSSNKLRAFqrgv----syeTITVVNVFPHDPQAFTQGLVYDrNDTLFESTGLYGKSSVRKVAL-HT 113
jgi:Deipe_4032           2 kaIALP----LLAGTAALGGTVfitqq-qprviTPAVLHTLPHDSQAFTQGLVIH-HGRLFESTGLYGYSKLREVEL-TT 74 
XP_002906452            72 NAdyfktgathgVPfvQEFCFDASI-FGEGVTVLGDKLFALTYKAEQVLVLSRRDFQLIGQFPLttStKEGWGLTTDGEF 150
bsuwp:MCON_2478         94 GR----------VV--DIVHLEDEF-FAEGIAIWKDRIIQLTWRSYQGFVWDKENLTRTGSFSY--R-REGWGITSDASR 157
WP_014587468            90 GE----------EI--RSRGLPPSL-FGEGIALIDDELLQLTWRSGVGLVWDLESFTVVGAFSY--P-TEGWGITADGQR 153 Metha...
Q01NY8                  79 GE----------VL--QRRDLSNPYiFGEGIVNWKDRLLQLTWQGQVGFIYDLASFAPKGEFHY--T-GEGWALTQDGKR 143 Candi...
Q9A519                  77 GA----------IE--AERTIDSRY-FGEGIVDWKNRVYALTWTDQVGFIYDIDSFETLGEFSY--P-GEGWALTRDDKR 140 Caulo...
PRJNA213647:NX02_03905  75 GQ----------VL--QRIDIPAGL-FGEGITDWKNELVSITWQNGKGFRWDATSLRRKGEFAY--P-GEGWGITQDGRQ 138
Q5VRH1                 139 GK----------VL--VQHEMDGRL-FGEGLTLLNDKLFQVVWMKNQGFIYDRHNFSKRESFTH--KmSDGWGLATDGKV 203 Japan...
NP_001305615            92 GK----------VE--TVHEMQASD-FGEGLTLLGESLFQLTWLQDTGFIYDRYNFSKFKKFTH--HmQDGWGLATDGKV 156
XP_003533156           114 GK----------VE--DVQKMDSSL-FGEGLTLLNNRLFQVTWLQKAGFIYNPKNLRKIGTFNH--AmKDGWGLATDGKV 178
jgi:Deipe_4032          75 GK----------VK--RRTKLPENI-FAEGLAQSGNDLVQLTWRNGFARIVDRESFKQKGQFTY--H-GEGWGLTQDGTH 138
XP_002906452           151 LIASDGSANVLFFDPrDDFKLHHSITVRKDGKEVTNVNELEYVEGELLANVWFEDHILRIDMATGDVLEQIDLDWISNMV 230
bsuwp:MCON_2478        158 LIMSDGSDALYFLDP-NDYSLQGSIRVTADGEPVKGLNELEYINGMIYANLWPSTWIAIISPDTGEVTGRIDLSGIMDEG 236
WP_014587468           154 LIMSDGSSTLRFLDP-ETFEVTGSLEVEADGKPLLGLNELEWVDGLIYANVWKADEIAIISPGSGRVVGWIDLAGLLSEE 232 Metha...
Q01NY8                 144 IIMSDGTSQLRFLDP-ETQQELGRLNVTSEGRQVPFLNELEWVKGEIYSNVWHQDRIARIDPATGNVVAWINLTGLWAGS 222 Candi...
Q9A519                 141 IMMSDGTAFIRFLDP-ETLKETGRIQVTDNGVPVTKLNELEWVKGELLANVWQTTRIARIDVATGRVKGWIELAGLLPEA 219 Caulo...
PRJNA213647:NX02_03905 139 LILSDGTPALRFLDP-ATMRETRRISVTVQGRPVRNLNELEYVDGAILANVWHSDYVLRIDPATGAVQAVIDLSGLREQA 217
Q5VRH1                 204 LFGSDGTSRLYQLDP-KSIQVMKTVTVKYQDNEVPYLNELEYINGEVWANVWQTDCIARVSHEDGLVVGWIFLHELRQHL 282 Japan...
NP_001305615           157 LFGSDGTSTLYKIDP-KTMKVIRKQVVKSQGHEVRYLNELEYVKDEVWSNVYGTDCIARISPKDGTVIGWILLQSLREDL 235
XP_003533156           179 LFGSDGSSTLYQIDP-QTFKALSKQVVHYKGHQVHNLNELEYINGEVWANVFMTDCIVRISPSDGNVLGWILLQNLRKEL 257
jgi:Deipe_4032         139 LILSDGSNVLRFLNP-KTYQVERQLAVQTKDSLVTYLNELEYGHGYILANVWLTTRIAVIDPDTGFVERWIDLSKIAQEH 217
XP_002906452           231 PNihTGAMmsspfkqdAV--MNGIAYDPVTRHVFVTGKLWDSMFEL 274
bsuwp:MCON_2478        237 DIpkr---------wvDV--LNGIAYDPSEDRLFVTGKLWPSLFEI 271
WP_014587468           233 ERerG-----------DV--LNGIAYDPASGRLFVTGKLWPWVFEI 265 Methanothrix harundinacea
Q01NY8                 223 DH--------------DVktLNGIAYDASRDRLFVTGKKWPNVFEI 254 Candidatus Solibacter usitatus Ellin6076
Q9A519                 220 GV--RGDRd-------DV--LNGIAYDAAGDRLFVTGKLWPKLFEI 254 Caulobacter vibrioides
PRJNA213647:NX02_03905 218 GA--GGPE--------AV--LNGIAYDKAGKRLFVTGKNWPKLFQI 251
Q5VRH1                 283 WN--SGNTe------iDV--LNGIAWDEENQRLFVTGKLWPKIYEI 318 Japanese rice
NP_001305615           236 KS--RGYKy------fEV--LNGIAWDRDGDRIFVTGKLWPKIFEI 271
XP_003533156           258 IK--AGNNd------iDV--LNGIAWDGEQKRIFVTGKLWPKLYEI 293
jgi:Deipe_4032         218 LN--SDKD--------NV--LNGIVYNPADETLYVTGKRWNKAyll 251
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