4UF5,4WLP


Conserved Protein Domain Family
DEUBAD_NFRKB
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cd21865: DEUBAD_NFRKB 
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DEUBAD domain found in nuclear factor related to kappa-B-binding protein (NFRKB) and similar proteins
NFRKB, also called DNA-binding protein R kappa-B, or INO80 complex subunit G (INO80G), is a regulatory component of the metazoan INO80 complex involved in chromatin remodeling, transcription regulation, DNA replication and DNA repair. It modulates the deubiquitinase activity of UCHL5 in the INO80 complex. It binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. The model corresponds to the DEUBAD domain (conserved domain within the UCH regulatory proteins RPN13, NFRKB/INO80G, and ASX) of NFRKB, which binds primarily to the C-terminal ULD domain of UCH-L5.
Links
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Statistics
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PSSM-Id: 439381
Aligned: 95 rows
Threshold Bit Score: 75.322
Created: 15-Oct-2021
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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heterodimer
Conserved site includes 31 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:4UF5: Homo sapiens NFRKB in complex with UCHL5; contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               #       #   #   #   #   ### #      #   #   #      ####  ##  #   #        
4UF5_B         6 LLEDPEIFFDVVSLSTWQEVlSDSQREHLQQFLPQFpedsaeQQNELILALFSg--ENFRFGNPLHIAQKLFRDGhfnPE 83   human
NP_001331013  92 ETFQLENLSEVLSNEVWRSClSDGERNYLRQFLPEGv-----DVEQVVQALLDg--ENFHFGNPSLDWGTAVCSGkahPD 164  thale cress
XP_024543704  60 EVFALENLHQILSIETWNSClSDLEKEHLCGLLPQGc-----DIEKTITALLAg--ENVNFGNPLTSWGELACSRamhPD 132  Selaginella mo...
NP_001143795  91 EIFSLKSLKGVLSYEAWSTSlTEAERKFLIQFLPSEt-----DAEENVKLLLTg--QNHHFGNPFLSWSSSLCYGdihPD 163  Zea mays
XP_031489469  95 EIFELDNLHGLLSCQAWKMClSASERKLLSQFLPKGi-----DVDQLLQSLFDg--ENFHFGNSFLEWGSLLCSGnlhPD 167  Nymphaea colorata
PHT92106      94 ETFELKNLSEVLSHKVWQANlSEDEREFLMQFLPEGs-----GPDDIVYKLLGe--ENFHFGNPFVKWQMICSGSf-hPD 165  Capsicum annuum
GBG81509     210 EILELSSLKGVLSAEVWEKHlTESDRQYLSRFLPAGv-----NTREAVSALLAg--RNLHFGNQFLTWSAALCHRelhPK 282  Chara braunii
KMZ75007      75 DIFELNNLAEVLSYHTWETDlSCLEKLYLQQFLPSGm-----DADLVVKSLLTe--ENLHFGNPFTKWSASLFSRelcSE 147  Zostera marina
TVU39391     147 EAFSFENLRSMLSYEVWATClTEDERKFLIQFLPSEt-----DAEENVHMASSlcyGDIHPDALLDKEKHIKAAEkayRI 221  weeping love g...
KAE8700015    65 EVFELKDFTKVLSYEVWLSHlSENERNFLMQFLPKGi-----DKERVLQVGTSlcsGHLHPDSVIQEEWSLKAEKkafYS 139  Hibiscus syriacus

Feature 1            #   #  ##  #   #  ##     ##  #
4UF5_B        84 VVKYRQLCFKSQYKRYLNSQQQYFHRLLKQILAS 117  human
NP_001331013 165 QIVSREECLRADKRRYYSNLEKYHQDIIDYLQTL 198  thale cress
XP_024543704 133 VVVLTQTRIHNERKNFRVSLRKFHQTMIQNLQQL 166  Selaginella moellendorffii
NP_001143795 164 ALLNKEKHIKKDEKAYHVNLLNYHSNMVETLKSW 197  Zea mays
XP_031489469 168 AVIQRELIFKANRKGYYSELQKYHNVMLEELQIL 201  Nymphaea colorata
PHT92106     166 NVMRQEQVFKANKKAYYMELQNYHDNMIGKLQLW 199  Capsicum annuum
GBG81509     283 VLQEKVMEKKRRRRAFYSDLRRYHRTMLGDLREM 316  Chara braunii
KMZ75007     148 SILHNSQHLKSRKKDYLSRLFKYHYEMIDSLLEW 181  Zostera marina
TVU39391     222 DLHNYHSNMVETLKKWRKRWLSCGDTENLFSDSP 255  weeping love grass
KAE8700015   140 ESQDYHNDIIEYLKKLKENWESCKYPEQEIVQNL 173  Hibiscus syriacus

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