Conserved Protein Domain Family
RING-H2_AIRP1-like
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cd23116: RING-H2_AIRP1-like 
RING finger, H2 subclass, found in Arabidopsis thaliana protein ABA INSENSITIVE RING PROTEIN 1 (AIRP1) and similar proteins
This subfamily includes Arabidopsis thaliana AIRP1 and RING-H2 finger B1a (RHB1A). AIRP1, also known as RING-type E3 ubiquitin transferase AIRP1, possesses E3 ubiquitin-protein ligase activity in vitro when associated with the E2 enzyme UBC8. It plays combinatory roles with AIRP2 in the positive regulation of the abscisic acid-mediated drought stress response. RHB1A is a probable E3 ubiquitin-protein ligase. Members of this subfamily contain a C3H2C3-type RING-H2 finger.
Links
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Statistics
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PSSM-Id: 438478
Aligned: 6 rows
Threshold Bit Score: 85.2137
Created: 14-Jun-2021
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H H C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-H2 fingers with bound zinc
  • Comment:C3H2C3-type RING-H2 finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-H-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #  #              # #  #  #          #  #    
Q93ZF6       100 AIDECPICLEEYeiDNPKLLTKCGHDFHLACILAWMERSeACPVCDKEL 148 thale cress
Q2HIJ8       135 EEDCCPICFEDYdvENPRLTTKCEHEFHLSCLLEWIERSdRCPICDKEV 183 thale cress
Q8LE94       177 DEDVCPTCLEEYtsENPKIVTKCSHHFHLSCIYEWMERSeNCPVCGKVM 225 thale cress
XP_024363149 188 DDDVCPTCLDGYteENPRITTGCGHNFHLACIYEWMERSnRCPICDKEM 236 Physcomitrium patens
OSX79776     346 EEDVCPTCLEGYsaSNPKMVPRCGHVFHLACIYEWLERSpYCPVCARRM 394 laver
PSC75162     149 DEEVCPTCLDPYteDNPKVLTRCAHHFHLPCLYEWLERSeTCPVCASPM 197 Micractinium conductrix

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