2L89,1H3Z,2NAS,2B8A,4RXJ


Conserved Protein Domain Family
PWWP

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pfam00855: PWWP 
PWWP domain
The PWWP domain is named after a conserved Pro-Trp-Trp-Pro motif. The domain binds to Histone-4 methylated at lysine-20, H4K20me, suggesting that it is methyl-lysine recognition motif. Removal of two conserved aromatic residues in a hydrophobic cavity created by this domain within the full-length protein, Pdp1, abolishes the interaction o f the protein with H4K20me3. In fission yeast, Set9 is the sole enzyme that catalyzes all three states of H4K20me, and Set9-mediated H4K20me is required for efficient recruitment of checkpoint protein Crb2 to sites of DNA damage. The methylation of H4K20 is involved in a diverse array of cellular processes, such as organizing higher-order chromatin, maintaining genome stability, and regulating cell-cycle progression.
Statistics
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Structure
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PubMed ReferencesClick to see Conserved Features Help

pfam00855 is classified as a model that may span more than one domain.
pfam00855 is the only member of the superfamily cl47601
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2L89_A                 9 G-DRILVKAPGYP-WWPALLLRRKETKDSLNTns---------sFn---vLYKVLFFPDFNF-AWV------KRNSVKPL 67   fissio...
Q4Q3Q3                12 N-SWVWVRQSGYP-WWPAMVLDPAQAGQDPPEg-----------------tDVVLLCGPSASaTLVfassadAEQ-LRPY 71   Leishm...
CAM40842              12 N-SWVWVKQHGYP-WWPAMVVDPAQTGQDLPEd-----------------sNVMLLCGPSTSaTLVfassanAEQ-LRPY 71  
XP_002900556           8 N-SVGWYILEGYP-WWPVYICDVFKLRPTLHLlgsghkkilkkaRdfpedFIVVYYFG-SHDfSLVg----lKKGVLRPW 80  
EGC39054              11 GiSLGFGKFTGYP-VWPCRTAFETEVGPNIKSkkk-------------ensILVYFFG-SKDyAYI------SKSSFLPY 69  
Q54GE4                 7 G-EVFSAT-YGQWgYWPVRIAKHSEVSGNTLKgkk--------------dnILVYFFG-SHDyGFV------KDSQFKSY 63   Dictyo...
XP_002000082          15 G-DFVFAKVRGFR-AWPARVLQEDGNI------------------------YQVYFYGTCNV-AKV------RGSQLFDF 61  
WGS:AAPP:GF18898-PA   14 G-DFVFAKLRGYR-AWPARVLQRFSNGNCN-----------------------VFFYGTCNY-ARV------PRRQICDF 61  
XP_002103508          14 G-DFVFAKVRGYR-PWPGRILKRIGATA-----------------------YSVYFYGTCNY-AKV------ARKEVVDF 61  
WGS:AADE:GA28522-PA   19 G-DLVFAKVRGYK-PWPAVITHDVNRKKQ----------------------YTVSFYGSGQI-GYI------LLKNLTPY 67  
2L89_A                68 LDSEIAKFLGSSKRKSK-------ELIEAYEASKTPPD 98   fission yeast
Q4Q3Q3                72 HGAA-EDAELIEAGRSDe------sCAAAIEEMLAAVA 102  Leishmania major
CAM40842              72 HGAI-EDAELIEAGRSDe------sCAAAIEEMIAAVS 102 
XP_002900556          81 DCAQKDQFLKGHPQHLAkkkgvmeDLTEAVQEVEEYLS 118 
EGC39054              70 DEANIEKYSISKNK----------QHQQGMEEIKNWNK 97  
Q54GE4                64 DPNDLHKQKFKLSDVK--------KLQKSIEEANEWLK 93   Dictyostelium discoideum AX4
XP_002000082          62 EAHKVRFGQLKQKQYG--------GFREAMEHAEKSLA 91  
WGS:AAPP:GF18898-PA   62 ESNLDRLGTLRARSAGSn-----aSFRGAMCHARNAFS 94  
XP_002103508          62 EKNLHRLGVVQQKGHACn-----pSFRGSMLQAREAFD 94  
WGS:AADE:GA28522-PA   68 LKLK-EEYSTEHHLKQA-------DFRRAMIQINEVAE 97  
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