7JTK


Conserved Protein Domain Family
Pro_isomerase

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pfam00160: Pro_isomerase 
Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organizms studied so far and catalyze peptidyl-prolyl isomerization during which the peptide bond preceding proline (the peptidyl-prolyl bond) is stabilized in the cis conformation. Mammalian cyclophilin A (CypA) is a major cellular target for the immunosuppressive drug cyclosporin A (CsA). Other roles for cyclophilins may include chaperone and cell signalling function.
Statistics
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PSSM-Id: 459694
Aligned: 62 rows
Threshold Bit Score: 114.275
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7JTK_W        25 IQQsSk-lL-GTVVLELFTDIAPATCANFIKYIkD----------GYQ--GTPLHR-IVpnGWVQGGD------------ 77  Chlamydomonas r...
A0BG75        16 MQVgKr-qP-VQVIIRLFDQQCPKTCENFRKLC-Qt---------KYG--GTNFHR-CSenFIAQGGD------------ 68  Paramecium tetr...
XP_001609098  67 FAAdRr-yL-GRVLVGLYGRHQPLTCENIVQLC-Kgyqlg-eqtiGYR--NSRISQ-IYpgNGIVLGDl----------- 128
Q019H4        67 LRAgGy-yL-GKVVFEIKEDACPITAKNFMQLC-Ey---------GCY--AGTMFK-VYpgNWVVGGDftkldevvynae 131 Ostreococcus tauri
EAX98182      17 VSIaGn-lI-GRVKIELRPDICPLACENFRRFC-TgeyrpkgvplGYK--GTRFHR-VVpgFIVQGGD------------ 78 
EDW33296     249 VEVrDtriQ-GRLIIQLFTEACPQVVLEFMRACtQg---------NSA--AITFSRtLTp-mWLEGRL------------ 303
Q23JQ1         5 IETs----L-GDLEVDLFVQKAPEISKNFLKLCkLk---------HYN--NALFYE-VQknYLTSIKS------------ 55  Tetrahymena the...
Q6BPQ5         7 TTE-------GNIVIDLFIDQQPLACYNFLKLCkLn---------YYF--FTPFYN-LHkdLIVSSGD------------ 55  Debaryomyces ha...
Q4N689        37 VQTdEk-aP-ETLIVGLYGNLVPKTVNNFIALC-Egtki---edkHYSyvDSAFHR-VIpnFMVQGGD------------ 97  Theileria parva
Q29NN3        25 VKHnKq--PiGRITFGLFGKLAPKTVANFRHIClRgin-----gtSYV--GARFHR-VVdrFLVQGGD------------ 82  Drosophila pseu...
7JTK_W        78 ----IVDGsgk-------------------gdPG----FVlpDETy--SVKHdAP--GVLGMA--TGgq--pHTA-NTQF 121 Chlamydomonas r...
A0BG75        69 ----YERGdgt------------------ggtSIwgnyFK--DENf--NIRHdKR--GIVSMAn-RGa----NTN-GSQF 114 Paramecium tetr...
XP_001609098 129 ----FHGDdpl------------------kscTIygrtMP--EESf--EAPFvQE--GDIAMLt-SRd----QSGlTSRF 175
Q019H4       132 dpdyFDFAnllpda-------------mpggqSIygayFD--DENy--DLKHsGA--GVLTMHn-NGge-vpGQN-GSQF 189 Ostreococcus tauri
EAX98182      79 ----CDTQdgygcis--------------------iygrefnDEPs--AYKF-DEt-GIVAMAn-SGp----NSN-GCQF 124
EDW33296     304 ----DMGPstvlkq------------------------dlrniEHdfdVLNH-GVdaGILSFPsrYVrs--hLCS-AINF 351
Q23JQ1        56 ----KKATtvfvet--------------------ggdqqYihDEIdptNKHN-KI--GLLSTSn-IGq----DRN-TSEF 102 Tetrahymena the...
Q6BPQ5        56 ----PDYPentdgdainsfgdvnvnnttvkqnKY----LPvpNSQh-eYVDN-SI--GLVSFVt-KKdtngkDLViGSQF 122 Debaryomyces ha...
Q4N689        98 ----IVNrngt------------------gsiSIyggtFE--DENf--KAKH-KK--GVIAMAn-RGp----NTN-GSQF 142 Theileria parva
Q29NN3        83 ----ILHGdgtgs--------------isiygD------YfeDEDkalAVEHnRP--GYLGMAn-RGp----DTN-GCQF 130 Drosophila pseu...
7JTK_W       122 YISLSPLP--FLDG-KR-VAFGRVLnkQSLENLLALQT---Lptfqne--rpvpdVVIASCHV 175 Chlamydomonas reinhardtii
A0BG75       115 FFTLTACP--QLDG-KH-VAFGEII--SGFEILDQISEi--Styggd----pkelVQILTAGV 165 Paramecium tetraurelia
XP_001609098 176 LITLTGNP--LLGR-HP-VVVGTVV--KGMKLIRSLGKe--Iikdgk----pvrdIRIINCGL 226
Q019H4       190 MITFDKKN--QLDD-RH-VAFGQII--EGYDVFCALQKlgdArqsge----tvqrVTVERCGL 242 Ostreococcus tauri
EAX98182     125 FITMNPAP--ELND-SY-VVIGKVF--EGMLVLRHIES---Vplkphs-eiptldCIISQCGE 177
EDW33296     352 TISFQPLS--ILNG--KrIAFGKVR--KGLHLLERIQD---Atghla---tsqgvVLITGCGV 402
Q23JQ1       103 FITLTSSHlqHFDE-KH-TIFGQVQ--VGIDILEKFNTdviVdndnk----pyinHRILhtiv 157 Tetrahymena thermophila SB210
Q6BPQ5       123 TISLTENTe-NLKSfSQ-VYFGKVV--EGFQVLEKINL---SvvenletrrllkdIRITHTHN 178 Debaryomyces hansenii
Q4N689       143 YITTVATS--WLDG-RH-VVFGELL--EGEYTLQAIEAt--Gtdsgk----psaqTIIKSCKV 193 Theileria parva
Q29NN3       131 YVTTVGAK--WLDG-KH-TVFGKVL--EGMDTIYAIED---Vktdtdd--fpvqpVVISNCGE 182 Drosophila pseudoobscura
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