6DS5,6MLU


Conserved Protein Domain Family
Seipin

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pfam06775: Seipin 
Putative adipose-regulatory protein (Seipin)
Seipin is a protein of approximately 400 residues, in humans, which is the product of a gene homologous to the murine guanine nucleotide-binding protein (G protein) gamma-3 linked gene. This gene is implicated in the regulation of body fat distribution and insulin resistance and particularly in the auto-immune disease Berardinelli-Seip congenital lipodystrophy type 2. Seipin has no similarity with other known proteins or consensus motifs that might predict its function, but it is predicted to contain two transmembrane domains at residues 28-49 and 237-258, in human, and a third transmembrane domain might be present at residues 155-173. Seipin may also be implicated in Silver spastic paraplegia syndrome and distal hereditary motor neuropathy type V.
Statistics
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PSSM-Id: 462007
Aligned: 119 rows
Threshold Bit Score: 93.3682
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6DS5_A        50 LLLLWVSVFLYGSFYYSYMPTVS-HLSPVHFYY--RTDCDsstts-------------lcsfPVANVSLTkgG--RDRVL 111
EEA06903      50 IIIFVLTWILYIAFYWYMIPPKI-SSFPIELNY--YKLTS----------------------PYPNNNFN--S--YYSNL 100
EGG21824     114 LLCAFISLINYAVLYSYFVPKVS-SEEPLYFDF--NGHRS----------------------VVATTEV-------AVSF 161
EFA81096      72 GLVGTLSLANYFIIYSYYVPRVV-TEEPLYFEF--GKKIT------------------------AHTDI-------AVEF 117
Q54K07        72 SFLFFVTILSYYAIYATLVPKVS-TEEPLFFDYsyKSTKK----------------------IVADVQA-------AVEF 121 Dictyostelium d...
XP_002126509  52 FVSLCISAILFGTIYFYNMPTIY-YSFPLKFEY--NRACMqrhkrfekfgghsrniyskecfPVSTLPLG--YadNYKLL 126
XP_018650266  31 VVTLAYGVMVFVFLYQTYIPTVK-LERELDLVF--DTKCNvqteys-----------nvcsfPTANFSVS--Es-GISLL 93 
1_pfamImport   1 CLTLIIAFLTPLVTRYALLPSSVhQQYPLNVVF--RTCEHdlhs--------------vcsfPAATLDYE--Q---NSLF 59 
XP_002636815  17 SIVAFIAAFLPLLIRYAALPTSVhHQYPLNVVF--RTCDHdlhs--------------vcsfPSATLEYE--K---NSLF 75 
Q8MXG1        16 SVAIFIAAVTPLLIRYCLLPSSVhHQYQLNIVF--QTCDHdlhs--------------vcsfPAATLEYE--K---NSLF 74  Caenorhabditis ...
6DS5_A       112 MYGQPYRV--------TLE------------------------------------------------------------- 122
EEA06903     101 KENNTYEFyksmtqnaDIKnnlvyhvhseemgtelmyqmsladayidfknvswttkklysynkpelnlnlfdvtifskik 180
EGG21824     162 QRSQLYDI--------YLN------------------------------------------------------------- 172
EFA81096     118 QRNKLYDV--------YLH------------------------------------------------------------- 128
Q54K07       122 QKNKHYNI--------YLE------------------------------------------------------------- 132 Dictyostelium d...
XP_002126509 127 QVGQSYSV--------VAK------------------------------------------------------------- 137
XP_018650266  94 TPKYPYML--------ILN------------------------------------------------------------- 104
1_pfamImport  60 SPDILYYL--------NVR------------------------------------------------------------- 70 
XP_002636815  76 SPNVAYYL--------NVR------------------------------------------------------------- 86 
Q8MXG1        75 SPNVAYYL--------NVR------------------------------------------------------------- 85  Caenorhabditis ...
6DS5_A       123 ------------------------------------------------LELPESPVNQDLGMFLVTISCYTR-GGr---- 149
EEA06903     181 lliihylplryvkrlinnisllfsrstklqhelekraygynvdiitelLYFPTIY-NLNIPPLMINLDLVKC-SNivens 258
EGG21824     173 ------------------------------------------------LEMPESPKNEDMGMFMVCLDLDSQdKWnp--- 201
EFA81096     129 ------------------------------------------------LELPESPKNEAAGMFMACLEIENQdKWnp--- 157
Q54K07       133 ------------------------------------------------LELPESPKNQDIGMFMACMDIDDHdKWnp--- 161 Dictyostelium d...
XP_002126509 138 ------------------------------------------------IEIPETPGNLDIESFMFIMEVEGHnTTniniq 169
XP_018650266 105 ------------------------------------------------LWLPDSIHNRNAGMSIITLELYGR-EHv---- 131
1_pfamImport  71 ------------------------------------------------LKFADVANSKFLGLFQSVLRVEDE-NSk---- 97 
XP_002636815  87 ------------------------------------------------LKFADIASSKKLGFFQSVISITEE-NGk---- 113
Q8MXG1        86 ------------------------------------------------LKFADVINTNKLGLFQNVITITDE-NQk---- 112 Caenorhabditis ...
6DS5_A       150 --------------------IISTSSRSVMLHYRSDLLQMLDTL--VFSSLLLFGFA--------EQKQ-LLEVELYADY 198
EEA06903     259 ie-----------etsnvnnIITNFKKTVSLDYIPNIALKLQEY--LLVLPFIFGFNlnnigfglRKG---LRIKMAENF 322
EGG21824     202 -------------------hKLLSVCRPATIKYRSPIIKSIKSV--LMSIPYIFGLY--------EEKQ-ELSISLVEDL 251
EFA81096     158 -------------------aKILNTCRPGILKYRSTITKLFRTF--TYALTNLFGIT--------EEKQ-IISIPMVENL 207
Q54K07       162 -------------------qKIHHTCRPAMLKYSSSLLKSLKSI--IFSVPYLFGVY--------EEKQ-IIVLPMGENF 211 Dictyostelium d...
XP_002126509 170 fkekqskkyrnkeleekpvvSKFRATNSVAIKYKSLIIKLINVA--LFWPFYLFDFY--------QETQ-TFDIVLFDQL 238
XP_018650266 132 --------------------LIQRFRKPFSMPYRSDEVRMISNI--LFSPLYIIGRM--------KEEL-LLSIEMSSSF 180
1_pfamImport  98 --------------------VLKQYTRSA---YVKEPGMMTKAYhlFFYPLYLFGFF--------DDHQnSLVIPMTADY 146
XP_002636815 114 --------------------VVQQYTKSA---YVKEPGLITKASqvFLFPLYILGYL--------YDYS-TLTISMSENY 161
Q8MXG1       113 --------------------ILKQYTKSA---YVKEAGLIQKAMhlFLFPFYFLGFF--------HDYS-TLAIPMSADY 160 Caenorhabditis ...
6DS5_A       199 r--ENSYVPTTGAIIEIHs--------KRIQLYGAYLRIHAHFTGLRYLLYNFPMTCAFIGVASNF 254
EEA06903     323 plfSNNENLDTSIHSSVNicgaiirikPALHIAGANLIFETKLPYWKDIIRSHPIITGFIITNLFT 388
EGG21824     252 p--FKRFYQTVSASISILn--------KNIQIYSARLSFQAKLSGLEYYMYYYPILSFFIGFCSLF 307
EFA81096     208 l--SKRFYQTISVNVNIQn--------PDIQIYKASLVFQAKLAGLEYYLYNYPYISFAVGFASLF 263
Q54K07       212 v--ANRFYQTISASIQINn--------PEIQIYRASLKFLANLNGFDYYLYYYPITSFIVGCSMIY 267 Dictyostelium discoideum AX4
XP_002126509 239 i--LNPAGLNWIARIYIDh--------PSITVNHAKLDVTLRFSGIQSLLYHWPVVSFVFGTAIVF 294
XP_018650266 181 q--FDVTQPVFEGRIILEs--------KRYLWSASELKIQTTLSGFQNILYYYPQVSFIICISVVS 236
1_pfamImport 147 r--ETAEVPSTKLTFTIQd--------KFANVEDAELIVTARFGLIRHILYYWPTVSYVAIFLAVL 202
XP_002636815 162 l--EQLGSPSTKLIFTVQd--------KFANIEEAELTVTARFGLIRHLIYYWPVMSYTAILVCGN 217
Q8MXG1       161 l--EGIDSPSTKLVFVVQd--------KFANIEEAELIVTARFGLIRHLLYYWPTTSYATIFVSTF 216 Caenorhabditis elegans
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