Conserved Protein Domain Family
PARG_cat

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pfam05028: PARG_cat 
Poly (ADP-ribose) glycohydrolase (PARG)
Poly(ADP-ribose) glycohydrolase (PARG), is a ubiquitously expressed exo- and endoglycohydrolase which mediates oxidative and excitotoxic neuronal death.
Statistics
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PSSM-Id: 461528
Aligned: 70 rows
Threshold Bit Score: 260.572
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006858709             127 MSGEESIKWFGETLPSMACLLMHLPSLLEAhyrdcdksreieerglpigtgLRVLES-------QEAGM--VVLSQELIG 197
XP_004365861             131 LWPAERKVLLGQTFPAILNFALDIEALFLSpye---------------skrVHLLRQ-------GERSSipLRLSRVQVR 188
EAS28217                  82 MGEAAEGQFFNRVWPVLVEIALEMPSLFPEs-------------------sLPILSE--------QHDQ--VTLSRRQVA 132
XP_001906208              89 TSFDTAEVFFAKVWSRIVDIALQMPVLFQNg-------------------rIPVLSR--------ENYS--LPFSRRQIA 139
WGS:AAFB:cds.EHI_057660A  91 LPPIESSHFFRDTIPIIASLAAIHPKLFPTp--------------------LI-LPT-------TPNSI--LRLNRLQVA 140
A0DVP8                    62 LDKNHRDMFFQYVLPKMAKYALDM------------------------------LELspkkellISEGS--IDFTRKEIY 109 Par...
A0E0D0                    62 LDQNLRVLFFQNALPKMAQYSLNL------------------------------LNSppkkellVTQGT--IQFTRKEIY 109 Par...
Q4CSW5                   110 MTPSERLAFFHVTLPWMKRRVIDGPVVLPRd--------------------LRALSQ-------GESRR--LILTHEEAA 160 Try...
Q38DD3                   102 MTAEERVQFFCFTLPWMKRAVLRGPELFPQe--------------------IPILSQ-------SDTHR--LLFTHEEAS 152 Try...
ESS33359                 109 YLEENPGKFFSHDLPFMATLVMRIDELFPNg-----------------------LQY-------ITPENpqVHLRKIQVF 158
XP_006858709             198 ALLACSFFCLFPSigRs--------fRNLP-TINFDYLFVSihNSYSPSQKHKIKCLVHYF----ERIC----------- 253
XP_004365861             189 CLLAHCLLCTFTD--Rhay-----arHNYP-QFEASGLLK----GGSSSRVAKLRMLLNYF----QRVS----------- 241
EAS28217                 133 CLVVHQFLCSLPSqpWptd-----ssPDFRiWYSTDI-------RHPKAVAAYISSVFTYF----GRLAgsshgsdspsl 196
XP_001906208             140 CLVVHQFLRTLSLppFrdd----dgtHDFGiWYSSQQ-------RHPVAVRGYLRALMLYFgd---------------vl 193
WGS:AAFB:cds.EHI_057660A 141 SLFALSFLGLFRLplKfq------daKQFPrCLS----------IVDKVSATKLRCYMAYF----STIGia-------ii 193
A0DVP8                   110 QFLSLSFFGLLVTqdE-----------KFPdTYN---LG-----HILQTDAEKSKCYLYYFim---------------as 155 Par...
A0E0D0                   110 QFLSLSFFGLLKIqhD-----------SFPtPCN---LH-----YILQEQPEKAKCYLHYFit---------------an 155 Par...
Q4CSW5                   161 TLLTCGFFSLFPGrcSnsrsk-skssETTS-SFNFADLFSLapPGRIESQVAKIRCLLQYF----IYCS----------- 223 Try...
Q38DD3                   153 TLLVCGFFSLFQGrsQvhkfgsstglHKLS-SFNFVRLLCNekPDRFSSQCAKVQCLLQYF----RYCA----------- 216 Try...
ESS33359                 159 TLIAAAFLGVIPHnqRallahhqkk---fvmnqnkldMFY----RGFMERKPKFQSVLIYFasmrERLGncwnemvkkgf 231
XP_006858709             254 SCMPM--GFV------SFER---------------------K----VLPLngssl---hisyPKTDFWSKSIVELC---- 293
XP_004365861             242 VEEPR--GDI------LLLR---------------------R----TVSN--------------IPDVMEAK-RLS---- 269
EAS28217                 197 LSAEW--PIIfrlrtlGVHK---------------------SalphTLPMgc------------------mlRPMTvtye 235
XP_001906208             194 CDEKTmdGWVveyslhSLPE-------------------------------------------NYDEISAQDRPLSelkv 230
WGS:AAFB:cds.EHI_057660A 194 NKDPIlqEQI------TYQRv----------------------------------------yGESPQWSNISIPVSa--- 224
A0DVP8                   156 PDLEN--EII------TVER---------------------IafnaDYHInqffpnsqakilEDAQLWSNCEKSLQ---- 202 Par...
A0E0D0                   156 NDLEH--ELV------TLER---------------------IdfnvNYHIhqffpnnqgiqiLDIKLWSNCDKNLQ---- 202 Par...
Q4CSW5                   224 HHADAveTCL------EFYR---------------------V----SFLS--------------FPDLGKSLNPMQ---- 254 Try...
Q38DD3                   217 RCTKEvwPCV------EIYR---------------------V----ARTS--------------FPDFERSTRAME---- 247 Try...
ESS33359                 232 VDMAPctGTC------ICSTleesvsiaptdeligfyrqsdKvadfVWSDgsvkg---tsasVSIDDIAKSTKALG---- 298
XP_006858709             294 PFKVLH---SGVIEDQ-PyEALEVDFANQYFGGGALHRGCV-QEEIRFMINPELIVGMLFAPRMEDNEALEIVGAERFCN 368
XP_004365861             270 PVRLHP---KGSIEVQp--LASHADFANKYPGGGVLSQGAV-QEEIRFACAPELMMSMLFCEVLHDNEAVIVQGAETFSD 343
EAS28217                 236 PIISTK---PSLLGI--PdGACIVS-ANKNVGFGQSAT----QEEMHVGSTPESCPIVLLTPTLQDTQILVVQGAEAMTV 305
XP_001906208             231 VVVETYdtlPGSLGVGdGdGQAVVISANRVVGFGQSAT----QEEVHVGISPEACPIVLFTPPLGDEQVLKVRGAQAMVN 306
WGS:AAFB:cds.EHI_057660A 225 NVTIV----DGLIEKE-NrNVLKAVFSSKAVGGNVLEDGCS-QEEIMFIKCPECMVALLIAPVLNANESFRIYNVLQYSE 298
A0DVP8                   203 TIEFV----DQKIEE--QqNSILVDFANKYVGGGVLSYGCV-QEEILFTIMPENIIAVLFCKVLDFHQVVIVKNTIRYSD 275 Par...
A0E0D0                   203 KIDFV----DTFLEE--QqNALIVDFANKYVGGGVLHTGCV-QEEILFTIMPENIIAVIFSKVLSNTEVIIIKNTIRYCD 275 Par...
Q4CSW5                   255 SVTMLE---EGLIED--NyGSLQVDFANKYVGGGVLRTGCV-QEEIRFMMCPELLLSCLFTEPLLDNEVLFMSGAGQYSV 328 Try...
Q38DD3                   248 PVVISE---NLLIEE--SyTNLQVDFANRCIGGGVLSSGCL-QEEIRFVTSPELLLSCLVCEELLDNEVVFVAGAASYSV 321 Try...
ESS33359                 299 GFEVFE---EGDITT--SdGDLQVDFADRYLGGLSMFEGYIaQEELIFIIYPEMLCVMLFSDIMKPNEAVVVKGVERFVF 373
XP_006858709             369 YRGYA-STFVF----------------------SGNYV-D--HKPLDIRGR--------RRTRIVAIDALCh-----pGI 409
XP_004365861             344 YTGYG-RTLAF----------------------GGSVH-Dt-TTPRLPTGT--------LMTEVLVMDAVKe-----pGR 385
EAS28217                 306 VEGYGrEARLL----------------------ETSYK-DslHGVHPHTW---------QRRVMLFMDALEfdm-ydsSE 352
XP_001906208             307 VVGKGrDII------------------------VGSML-Dp-PQGGDATW---------KFRTMLFMDALEldlvndgRL 351
WGS:AAFB:cds.EHI_057660A 299 VTGYA-TEISF----------------------KGNVAsL----------Q--------LKHDFVIFDALIcv----dKK 333
A0DVP8                   276 YEGYA-NSFRF--------------------------------VQRQPKN---------MNQNILVLDAINyk---nnPD 310 Par...
A0E0D0                   276 YLGYG-LSFHF--------------------------------LQRKPSN---------LNQNILVLDALYyg---nyPT 310 Par...
Q4CSW5                   329 SVGYA-SGFRFicghsphfa----klgaatstpREIWV-E--LVPTSLRNEkdctavmlRNSCVVAMDAINyc---gcEE 397 Try...
Q38DD3                   322 TEGYA-KTFRYisgctpdiiplsgrmfrvdsceQGMHV-D--KVPVKLVGRndeaprfvRNTCIVAMDAVDfs---daVD 394 Try...
ESS33359                 374 SQGYE-WTFQItaaagd-----------wtelpSNKHFsVqgVVPLDSLGR--------RNVAIVGIDAVQfh----ePN 429
XP_006858709             410 Q--QYGADCLLRETNKAFCGFMDHSKCHQymnifkegklqdldngahaaiskteddsgikarncsdreaeatacststta 487
XP_004365861             386 A--QFRKAYCERTLRKALAAFEPTALSSGetvagqplfpvasapissga------------------------------- 432
EAS28217                 353 GvpDLLPGHTDRELLKAYNAFSSQQGGHTy-------------------------------------------------- 382
XP_001906208             352 A--DLDPGNMEREIAKAYTAFSSSLDGTI--------------------------------------------------- 378
WGS:AAFB:cds.EHI_057660A 334 L--QYTQYGIDRELNKVFSAIKKTDDDCDv-------------------------------------------------- 361
A0DVP8                   311 K--QFQQNEIMREINKAFIGFSLSQSAKEee------------------------------------------------- 339 Par...
A0E0D0                   311 L--QFQSKFILRDINKAFIGFSLSQSAKEed------------------------------------------------- 339 Par...
Q4CSW5                   398 K--QYLASSIIRETRKAFAAFKGTPDSILtsv------------------------------------------------ 427 Try...
Q38DD3                   395 N--QFRKDFIIRETHKAFVAFKGIPDSTLssv------------------------------------------------ 424 Try...
ESS33359                 430 K--QYSPVMVNRELMKAAVGFKGDPYELIvsg------------------------------------------------ 459
XP_006858709             488 mnrstqvtdlfeeaklkndqglnccenVGIATGNWGCGAFGGDHELKSMIQWLAASQ------ALRPfLVYYTVGDKATK 561
XP_004365861             433 --------stsaaataslppstpqiqsWPIATGNWGCGVFLNDFHLMFMLQWIAASL------VGRS-LDYYLFETKAID 497
EAS28217                 383 ---------------------------SRIVTGLWGCGAFGGNREIKTILQWCAASL------AGVR-LEFICSGDAQRE 428
XP_001906208             379 ---------------------------SEIKTGPWGCGAFRGDPEVKMLLLWLASSM------VGVN-LTVVC--DYELQ 422
WGS:AAFB:cds.EHI_057660A 362 --------------------------mQPFATGKWGCGSMLGDSRLKFIIQLLASSL------TGRE-MRYHPLNDIQHQ 408
A0DVP8                   340 -------------------------flYPISTGKWGCGVFKGNTQLKTIIQLLAFSAstksenQKRR-MIFSTFKDKQLQ 393 Par...
A0E0D0                   340 -------------------------flLPISTGKWGCGAFRGNCELKTLIQLIAFSAsrkridQKRR-MIFSTFEDEQLQ 393 Par...
Q4CSW5                   428 -------------------------hsGPVATGNWGCGAFSGDRELKTMIQWCAASE------AKRP-LIYSSINDSDLC 475 Try...
Q38DD3                   425 -------------------------hsGPIATGNWGCGAFGGDRELKLLLQWCAASQ------AGRP-LIYSAFGDIALC 472 Try...
ESS33359                 460 -------------------------srQPIATGLWGCGVFNGDAQLKTLIQWLAASY------AGRS-MKFYTFSNKSVD 507
XP_006858709             562 R 562
XP_004365861             498 V 498
EAS28217                 429 F 429
XP_001906208             423 T 423
WGS:AAFB:cds.EHI_057660A 409 N 409
A0DVP8                   394 F 394 Paramecium tetraurelia
A0E0D0                   394 F 394 Paramecium tetraurelia
Q4CSW5                   476 Y 476 Trypanosoma cruzi
Q38DD3                   473 N 473 Trypanosoma brucei
ESS33359                 508 G 508
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