Conserved Protein Domain Family
DUF3537

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pfam12056: DUF3537 
Protein of unknown function (DUF3537)
This family of transmembrane proteins are functionally uncharacterized. This protein is found in eukaryotes. Proteins in this family are typically between 427 to 453 amino acids in length.
Statistics
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PSSM-Id: 463448
Aligned: 41 rows
Threshold Bit Score: 436.262
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002894263  34 DELHSFRKYLRWMCVDHSSPWTAILSWTMFVVFTLVVPAISHFLLACadcdsYH--SR-PYDSVVQLSLSSVATVSFLCL 110
XP_006351484  35 vSLNKLERFLRVLGFCQYSIFSAALSWLAFVVFSIVVPLLVVYFGYCsncelYQ--IN-DFELEVLVCQSVAAFISLLCI 111
ERN12560      85 DELYNFRMSLRWWALDQSSKPTKLISWLTFCVFTLVVPITSLVLVRAp-------sRAiAIEKWVQLPESGLAAIAFFSL 157
EEF34410      45 DELRHFRICLKWCALDHSSCLGKFISYSTFIFFAIILPILSSLSVKLppsaaLR--DPiSFNTLVQLPESGLALIAFFTL 122
XP_006382205  55 DELRNFRISLKWCALDHSTCIGKFVSCFIFVFLAIILPIVSSLSIRVpssapAN--DPiSYNKLVQLPESVLALISFFSL 132
XP_003527815  49 HELRNLRRSLQWCALDHSSLVGQLISYVVFIFLTIAVPLFTSLFVHVpssssQL--DPfNFNKLLQLPQSALAVIAFFTL 126
XP_003545561  60 DELRNFRISLKWCALDHSSFIGRLISYVTFIFFTIVVPLFTSIFVEVpasapED--DPiSFNKLVQLPESGLAIVAFFTL 137
XP_009420001  56 DELRNFRVCLKWCALDHSTAAGRAVSYAAFVALALLVPAATSLSVRAppaasSSa-SSvSFHKLVQVPASSLAAISFLTL 134
XP_004973917  54 DELRSFRVFLQWCALDHSTRAGRAASYAAFLVLALLVPASISLSLRAdaslsPVsaSAiTFNRVSQVPATGLAVISFVTL 133
EFJ27549       8 DELQRFRLSLLWIGLDQSTPVRIAFSWIIFLLFAIVLPVINSVATSCsr--cYH--RQlPFERLVYVSESALAIVSFACL 83 
XP_002894263 111 TRFVSKy-GLRRFLFFD-KLWDESETVRRNYTNQLNTSLHIVSYFVIPCFSAMSAYK-IWWYASGGsqiPFLg------- 180
XP_006351484 112 SHNLRKy-RIRKLLFVD-RYHGQLTHFSELYLKKIRVFYYLVVSWMAIFFLMKIARE-VTRAVHIYd------------- 175
ERN12560     158 SRSVRKh-GLRKILFLD-QLAEDTHEIRRNYSSELERAFKGLAFMLLPSFSVELAHK-VVFFSCTDvgiLKG-------- 226
EEF34410     123 SRFFSTy-GLRQLLFLD-GLQDDSLFVRRGYSRELDKAFRYLACILLPSFFVELAHK-IIFFSTVEitlPYIs------- 192
XP_006382205 133 FRFFKRy-GLRQLLFLD-DLQEDSLFIRRGYSRELDKAFRYLACILLPSFFVEVAHK-IIFFSTVKiwlPCNvf------ 203
XP_003527815 127 SRFFPRh-GLRQLLFLD-VLQDDSTYVRRGYTRELQKAFRYLACMILPSFFVELVHK-IIFFSSVEisiPC--------- 194
XP_003545561 138 SSFFKRy-GLRQLLFLD-ALQEDTTYVRRGYTRELEKAFRYLTYIILPSFFMELAHK-IIFFSAVKisaPHIs------- 207
XP_009420001 135 AAFFRRy-GLRQLLFLDgALRDDTTFVRHCYARELDRSFRHLVYILLPSFSVELAHK-ILFFSTVSvavPLSta------ 206
XP_004973917 134 AAFFRRlgGLRQLLFLDgALRDDSPYVRRGYARELDRAFRLLAALLLPSLCVEAAHKaVFYFCTVRvdpPAAlgavlppl 213
EFJ27549      84 SFLLRRh-GLRKVLMLE-KLDRESQEVQQNYRAKVNFAFRLLAMIILPSMVVKLVRE-IWWFSRATvalPGIp------- 153
XP_002894263 181 --nVVLSDTVACIMELCSWLYRTTVIFLVCVLFRLICHLQILRLQDFA-KLFQ-ID-SDVGSILSEHLRIRRHLRIISHR 255
XP_006351484 176 --gSIWWSIGIVVASLVSWAYPTIIFIVGTALFHLVGNLQVIHLEHFG-ELLD-MD-MDVSVYINEHMRLTCYVCKISHR 250
ERN12560     227 ---GFAAKWVVFGFVLASWIYRTGVYLLVCVLFSLTCELQILRLQGLRkKLEDgGSeSEVGVIFREHVRIRRQLSVMSHR 303
EEF34410     193 --lGVPLNSVMFLLVLASWVYRTGVFLLVCVLFRLTCELQILRFEGLH-KLFE-GCeSDAGAIFKEHFRIKKQLSGTSHR 268
XP_006382205 204 -pgNIPLNSIMFVLVLASWVYRTGVFLLVCVLFRLTCELQILRFDGLH-KLFD-GCeSDAGVIFREHVRIKKQLSFTSHR 280
XP_003527815 195 ---GTSLNWVVFVLVLVSWVYRTGLFLLACVLFRLTCELQILRFEGLR-KLFE-GCgSDANMIFREHVRIRRQLWITSHR 269
XP_003545561 208 --pGFPLNSIVFVLVLVSWVYRTGVFLLVCVLFRLTCELQKLRFEGVH-KLFE-GCgSEAGVIFKEHVRIRRQLWVTSHR 283
XP_009420001 207 -psGVPWNSIAFIATLASWVYRTGVFLLVCVLFRLTCELQILRFEGFY-KMFDeGDgSHCQAIFREHMRIKRQLLVTSHR 284
XP_004973917 214 llpRVPWRAVALVATVASWVYRTGVFLLVCVLFRLTCELQILRFEGIH-HMFDvEArAAAAEIFAEHRRIRTQLLATSHR 292
EFJ27549     154 --hGPALRSVMCTLVMLSWLYKAGVFLLMCVLFRLMCSLQILRLQGYS-TLLA-KS-LDVPELLLEHVRIRKQLFKISHR 228
XP_002894263 256 YRSFILCLLILVTGSQFSSLLITTKAYTEVNMYRAGELALCSMTLVTALLILLRSASKITHKAQAVTCLAAKWHVCATLE 335
XP_006351484 251 FRMFLLLEYLIVTVSQCIVLLQTTANQGIVNFVNAGDFVVISIVQLVGLLICLNAAAKISHRAQGLGSVASRWHALVTCN 330
ERN12560     304 CRGFILGSLGTITVSQLGALIMVFSSKFQKDFFNSGDLLVCSAVQLCGVFLCLLGAAKITHRAQGIVSIATRWHASMTLE 383
EEF34410     269 YRFFIIACSVTITITQLGALLLVLAFKSEKNFFNSGDIVICSVVQLSGFFLCLLGAARITHRAQGIVSIATRWHMMVTSA 348
XP_006382205 281 YRFFIISCLVTITVSQFGSLLLVLGFNNEKNFFNSGDLVICSAVQLCGFFLCLLGAARITHRAQGIVSMATRWHMIVASA 360
XP_003527815 270 YRFFIITCLVTITISQLGSLLLVLESKSATTFFNSGDLVICSAVQLCGFFLCLMGAARITHRAQGIVSIATKWHMVVTNA 349
XP_003545561 284 YRFFIIGCVVTITVSQLGALLLVLASKSDKTFFNSGDLVICSAVQLSGFFLCILGAARITHRAQGIVAIATRWHMLVTTA 363
XP_009420001 285 YRIFILGCLVTISASQLGALMIVLASKSKKTFCNSGDVVVCSAVQLSGFFMCLLGAARITHRAQRVVSIASRWHMILSSA 364
XP_004973917 293 YRVFIICCLVTITVSQLGALLVALSSRDEKSFSNTGDLLVGSAVQLSGFFMCLFGAARITHRAQRIVSIASQWHVSLVAM 372
EFJ27549     229 CRIFILASMFIITSSQFISLFFILSYKESVHFFIAGSLAVSSAVQLSGILTCMNGASKITHRAQKLISLVSEWHAVWTCS 308
XP_002894263 336 SFDQtvDGETPTlvarnnnndnnngH----DvitltESDSDEYGDEEDDLDN----NN-IIPAYAfS-------TMSFQK 399
XP_006351484 331 SNDA--SVSESSsdgrnv-etpktaGql--------slNYS-----EGDLES----AD-CMPPPAnVqlt--stMTSYHK 387
ERN12560     384 P-----KTKRSYsnsgeps-------------appingENFLATNNSSDPES----PDaLFISPSl--------HSSFEV 433
EEF34410     349 SSRS----EQGKclvr-----------------------etdDSIQTDDADP----PDiFITQD----------ASSFQT 387
XP_006382205 361 SASA--RIDQGKshvp-------------------eadGTLASNTEDSESDS----SDnFIAISSqD-------PCSFQT 408
XP_003527815 350 SAES----EHWKtqm-----------------------pegLPSPTASDSDS----SDiYISVTTq--------GPSFQT 390
XP_003545561 364 SAES----EHCEaqv-----------------------segLASDDDSDSDDs---SNiHVSVIPpQ-------LSSFQT 406
XP_009420001 365 ADR---KADPPTpava-------------------esdDISDSGSPEGSVGGavphAQ----------------ASTFEG 406
XP_004973917 373 HHGS--KSSP--------------------------------ASTSASDVDA----SRvSGSSAAvSsqaepgaACSYKS 414
EFJ27549     309 AMTS--DFNKPAfktatppcypllrQqsdiK-----ACDLFSAKSQDSHYDN----------------------ECYFRQ 359
XP_002894263 400 RQALVSYFENNRAGITVYGFTLDRGTLHTIFGL 432
XP_006351484 388 RQAFVTYVESNPGGFSIYGWRVDRLLINTLFFv 420
ERN12560     434 RQAFVSYLQHNSGGITLFGFTLDRGLLHTIFAF 466
EEF34410     388 RQAFIAYLQHNHGGITLFGFALDRGLLHTLFAF 420
XP_006382205 409 RQALVAYLQHNNGGITLFGFALDRGLLHTLFAF 441
XP_003527815 391 RQALVTYLQHNYGGITLFGFVVDRGLLHTLFAF 423
XP_003545561 407 RQTLVTYLQHNHGGITVYGYSLDRGLLHTLFAF 439
XP_009420001 407 RHALVLYLQHNGGGITLFGFALDRGLLHTLFVf 439
XP_004973917 415 RQALVTYLRHNGGGITLFGFTLDRGLLHTIFVF 447
EFJ27549     360 QQSFLRYLQHNSPGISVYGFVLDRGSLYTLFAL 392
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