2R50,3QQQ,3QQR,1D8U,3ZHW


Conserved Protein Domain Family
class1_nsHb-like
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cd14784: class1_nsHb-like 
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Class 1 nonsymbiotic hemoglobins and related proteins
Class1 nsHbs include the dimeric hexacoordinate Trema tomentosa nsHb and the dimeric hexacoordinate nsHb from monocot barley. This subfamily also includes ParaHb, a dimeric pentacoordinate Hb from the root nodules of Parasponia andersonii, a non-legume capable of symbiotic nitrogen fixation. ParaHb is unusual in that it has different heme redox potentials for each subunit.
Links
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Statistics
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PSSM-Id: 381291
Aligned: 8 rows
Threshold Bit Score: 252.051
Created: 28-Dec-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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heme bindinghomodimer
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:
  • Structure:3QQQ: Trema Tomentosa non-symbiotic hemoglobin binds heme; contacts at 4A
  • Structure:1D8U: Oryza sativa non-symbiotic hemoglobin binds heme; contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                             ####            #   #  ##  ##           
2R50_A     13 FGEEQEALVLKSWAVMKKDAANLGLRFFLKVFEIAPSAKQMFSFLRDSdVPLEKNPKLKTHAMSVFVMTCEAAAQLRKAG 92  teosinte
3QQQ_A     16 FTEEQEALVVKSWAVMKKNSAELGLKFFLKIFEIAPSAKNLFSYLKDSpIPLEQNPKLKPHAMTVFVMTCESAVQLRKAG 95  Trema tomentosa
3QQR_A     10 FTEEQEALVVKAWAVMKKNSAELGLQFFLKIFEIAPSAKNLFSYLKDSpVPLEQNPKLKPHATTVFVMTCESAVQLRKAG 89  Parasponia andersonii
1D8U_A     14 FSEEQEALVLKSWAILKKDSANIALRFFLKIFEVAPSASQMFSFLRNSdVPLEKNPKLKTHAMSVFVMTCEAAAQLRKAG 93  rice
3ZHW_A      9 FTEEQEALVVKSWSVMKKNSAELGLKLFIKIFEIAPTTKKMFSFLRDSpIPAEQNPKLKPHAMSVFVMCCESAVQLRKTG 88  thale cress
Q9M630     24 YSKENEQLVKQSWEILKKDAQRNGINFFRKVFEIAPGAKAMYSFLRDStIPFEENPKVKNHARYVFMMTGDAAVQLGEKG 103 Physcomitrella patens
ABR17163  100 FSEEQEALVKKSWNAMKPNAPQLGFKFFLRVFEIAPSAKRLFSFLQDSdVPIEKNPKLKAHGLIVFKMTCESAVQLREKG 179 Sitka spruce
EFJ10590   33 ESKSNAELVKDSWRVLKRDAGTHATAFFLKIFEIAPTAKQLFSFMRDStVPAEANPHLKSHALVVFTMTCEAAILLGEDP 112 Selaginella moelle...

Feature 1               ##  ##  # #   ##  #                            #  ##  #     
2R50_A     93 KVTVrettLKRLGATHLRYGVADGHFEVTGFALLETIKEALPaDMWSLEMKKAWAEAYSQLVAAIKREMK 162 teosinte
3QQQ_A     96 KVTVresnLKRLGAIHFKNGVVNEHFEVTRFALLETIKEAVP-EMWSPEMKNAWGEAYDQLVAAIKSEMK 164 Trema tomentosa
3QQR_A     90 KVTVkesdLKRIGAIHFKTGVVNEHFEVTRFALLETIKEAVP-EMWSPEMKNAWGVAYDQLVAAIKFEMK 158 Parasponia andersonii
1D8U_A     94 KVTVrdttLKRLGATHLKYGVGDAHFEVVKFALLDTIKEEVPaDMWSPAMKSAWSEAYDHLVAAIKQEMK 163 rice
3ZHW_A     89 KVTVrettLKRLGASHSKYGVVDEHFEVAKYALLETIKEAVP-EMWSPEMKVAWGQAYDHLVAAIKAEMN 157 thale cress
Q9M630    104 AYQVleskLQKLAATHVNAGVTDDQFEIVKEAILYAIEMGVP-DLWSPELKSAWGDAYDMLAEQVKAEMH 172 Physcomitrella patens
ABR17163  180 TVTFsesnAKDMGKLHLTYGVLDEHFDVVKFCLLETIKDAVP-DIWSPEMKIAWDEAYTQLAEAIKSEMK 248 Sitka spruce
EFJ10590  113 TLAAlrpkLLEMGHTHVVHKVIDEHFDVVKYALLETLKEALK-DEWSPSMKAAWAEAYDAVTKIIKDEMH 181 Selaginella moellendorffii

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