Conserved Protein Domain Family
RING-H2_RHA1-like
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cd23121: RING-H2_RHA1-like 
RING finger, H2 subclass, found in Arabidopsis thaliana RING-H2 finger A1a (RHA1A), A1b (RHA1B) and similar proteins
This subfamily includes Arabidopsis thaliana RHA1A, RHA1B and XERICO. RHA1A is a probable E3 ubiquitin-protein ligase that may possess E3 ubiquitin ligase activity in vitro. RHA1B possesses E3 ubiquitin-protein ligase activity when associated with the E2 enzyme UBC8 in vitro. XERICO functions on abscisic acid homeostasis at post-translational level, probably through ubiquitin/proteasome-dependent substrate-specific degradation. Members of this subfamily contain a C3H2C3-type RING-H2 finger.
Links
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Statistics
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PSSM-Id: 438483
Aligned: 6 rows
Threshold Bit Score: 69.8213
Created: 15-Jun-2021
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding siteputative active
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H H C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-H2 fingers with bound zinc
  • Comment:C3H2C3-type RING-H2 finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-H-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #  #                        # #  #  #            #  #    
Q9SUS4        83 EDCCTVCLSDFESDDk---------vRQLPKCGHVFHHYCLDRWIvdyNKMKCPVCRHRF 133 thale cress
XP_004359507 308 DQRCLICLEDFNESEs---------lKELPKCHHIYHPQCIDIWLr--NKNKCPLCKVEL 356 Dictyostelium fasciculatum
Q9SUS5        82 EDCCTVCLSDFVSDDk---------iRQLPKCGHVFHHRCLDRWIvdcNKITCPICRNRF 132 thale cress
RIB22483      69 NDVCAICLDEFNDGEk---------lRQLPKCSHIYHVECIDRWLt-tKSSLCPLCKQDA 118 Gigaspora rosea
Q4X393        23 DNICAICNNSLENTCticirpgnscpPAFGKCGHHFHLHCMEKWIr-qNKLTCPCCRADW 81  Plasmodium chabaudi
Q9SI09       100 DNECSVCLSKFQGDSe----------INKLKCGHLFHKTCLEKWId-yWNITCPLCRTPL 148 thale cress

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