1XQG,4GA7,4ZK0,2DUT,2ARQ,1UHG,1JTI


Conserved Protein Domain Family
serpinB

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cd19956: serpinB 
Click on image for an interactive view with Cn3D
serpin B family, ov-serpins
The clade B of the serpin superfamily corresponds to the ovalbumin family of serpins (ov-serpins), a family of closely related proteins, whose members can be secreted (ovalbumin), cytosolic (leukocyte elastase inhibitor, LEI), or targeted to both compartments (plasminogen activator inhibitor 2, PAI-2). Family members are also characterized by N- and C-terminal extensions, the absence of a signal peptide, and a Ser rather than an Asn residue at the penultimate position. In general, SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate blood coagulation cascades. Non-inhibitory serpins perform many diverse functions such as chaperoning proteins or transporting hormones. Serpins are of medical interest because mutants can cause blood clotting disorders, emphysema, cirrhosis, and dementia. A classification based on evolutionary relatedness has resulted in the assignment of serpins to 16 clades designated A-P along with some orphans.
Statistics
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PSSM-Id: 381072
Aligned: 52 rows
Threshold Bit Score: 483.603
Created: 29-Nov-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
reactive center
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:reactive center loop (RCL)
Evidence:
  • Comment:depending on the conformational state, RCL is surface accessible in the active form or buried and inserted as the central beta strand in the inactive form
  • Structure:1UHG_A: Gallus gallus S-ovalbumin in non-loop-inserted thermostabilized form
  • Structure:1JTI_A: Gallus gallus ovalbumin, P1-P1' cleaved, loop-inserted structure

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
1XQG_A        21 ANSAFAVDLFKqlsekeplgNVLFSPIALSTSLSLAqvgakgDTANEIGQVLHfenv----------------------- 77  human
2DUT_A        48 SIGNFTVDLFNklnetnrdkNIFFSPWSISSALALTylaakgSTAREMAEVLHfeqa----------------------- 104 chicken
2ARQ_A         7 ANTLFALNLFKhlakasptqNLFLSPWSISSTMAMVymgsrgSTEDQMASVLQfnevga--------------------- 65  human
1UHG_A         6 ASMEFCFDVFKelkvhhaneNIFYCPIAIMSALAMVylgakdSTRTQINKVVRfdklpgfgdxi---------------- 69  chicken
XP_020792381   9 ANTTFALALYKklieddkigNIFCSPFSISAALAMVllgargNTATQMSEVLGfsepsappsgddlqcslqtdrpylmqs 88  great blue-spot...
XP_004628459   7 ANGTFAIRLLKllgqedparNVFFSPVSISSALGMVllgakgSTAAQIAEVLAlnaq----------------------- 63  degu
NP_956230      7 AHARFCLSLFQkisdgdssqNVFFSPLSISAALSMLslgaagNTKDQMSQTLHfdga----------------------- 63  zebrafish
XP_008295863  11 AITKFCLALLSklskddstaNLFISPFSISSALSMVmlgaagNTATQMSKVLCftesdnagaqrtrmlpmqqvhadrqar 90  bicolor damselfish
XP_020792369  35 ANITFTLDLFRslgnqnkssNVSFSPLSVSAALSMVllgakgRTADQMRECLKtkdc----------------------- 91  great blue-spot...
AAH54232       7 ANGTFAINFFAklnesnktgNIFVSPLSISSALAMVllgakgNTATQMSQVLKfdkl----------------------- 63  African clawed ...
Feature 1                                                                                        
1XQG_A        78 ---------------------------------------------------------------------------kdvPF 82  human
2DUT_A       105 ---------------------------------------------------------------------------eniHS 109 chicken
2ARQ_A        66 -------------------------------------------------------------------------aadkiHS 72  human
1UHG_A        70 --------------------------------------------------------------------eaqcgtsvnvHS 81  chicken
XP_020792381  89 qmqt-------------------------------------------rmqmrtqiqrtsrlpaylrkclkpeggkdnvDE 125 great blue-spot...
XP_004628459  64 ---------------------------------------------------------------------------rdiHL 68  degu
NP_956230     64 --------------------------------------------------------------------------esqiHA 69  zebrafish
XP_008295863  91 mqkqsqmqapvgtklpgylvkilkekngdagktddagktdvaaktdkvdkadddtkktddvsggdpqlqsepskpvnvPA 170 bicolor damselfish
XP_020792369  92 ---------------------------------------------------------------------------kdvHS 96  great blue-spot...
AAH54232      64 ---------------------------------------------------------------------------dgaHC 68  African clawed ...
Feature 1                                                                                        
1XQG_A        83 GFQTVTSDVNklssfysLKLIKRLYVdkslnlstEFISSTKrpyakELETVDFkdklEETKGQINNSIKDLTDGHFENIL 162 human
2DUT_A       110 GFKELLTAFNkprnnysLRSANRIYVektyallpTYLQLSKkyykaEPQKVNFktapEQSRKEINTWVEKQTESKIKNLL 189 chicken
2ARQ_A        73 SFRSLSSAINastgnylLESVNKLFGeksasfreEYIRLCQkyyssEPQAVDFlecaEEARKKINSWVKTQTKGKIPNLL 152 human
1UHG_A        82 SLRDILNQITkpndvysFSLASRLYAeerypilpEYLQCVKelyrgGLEPINFqtaaDQARELINSWVESQTNGIIRNVL 161 chicken
XP_020792381 126 SFAQLLTELNkpealyvLSIANRLYGekqytfdkLFLAETKkhygaELETVDFvsnpEESRVHINNWVEEQTQNKITNLL 205 great blue-spot...
XP_004628459  69 GFQSLLTQVRrpgapfsLSIANRLFGeescqflsPFQQSCQnyyeaELEQLPFikapERSRKHINAWVSTKTAGKIEELL 148 degu
NP_956230     70 GFTKLLTEMNragaphtLSLASRLYGeqscrfqeTFLSDTRrlygaELQPLDFisqpEASRGIINRWVEQQTHEKIRDLL 149 zebrafish
XP_008295863 171 GFAEVLSELNqidasyaLDIANKLYGeksyqfieAFLAEIQkeykaELESVDYqnnaEEARISINNWVEKQTQGKIKDLL 250 bicolor damselfish
XP_020792369  97 SFAALLKKLNktdpsyaVSIANRLYGeqsyefieMFLEGTRefynaELETVDFikkaEEARIQMNRWVEEQTQGKIKDLL 176 great blue-spot...
AAH54232      69 NFQSLISEINkpgtnylLRTANRLYGeksytfleEFLGSTQkhyhaDLRAVDFckkaEESRGEINEWVAQKTEGKINDLL 148 African clawed ...
Feature 1                                                                                        
1XQG_A       163 ADnsvndqtKILVVNAAYFVGKWMKKFseseTKESPFRVnktdtKPVQMMNMEatFSMGNIdsinSKIIELPFQnkhLSM 242 human
2DUT_A       190 SSddvkattRLILVNAIYFKAEWEVKFqaekTSIQPFRLsknksKPVKMMYMRdtFPVLIMekmnFKMIELPYVkreLSM 269 chicken
2ARQ_A       153 PEgsvdgdtRMVLVNAVYFKGKWKTPFekklNGLFPFRVnsaqrTPVQMMYLRekLNIGYIedlkAQILELPYAg-dVSM 231 human
1UHG_A       162 QPxsvdsqtAMVLVNAIVFKGLWEKAFkdedTQAMPFRVteqesKPVQMMYQIglFRVASMasekMKILELPFAxgtMSM 241 chicken
XP_020792381 206 PAgvvdastRLVLVNAIYFKGKWNSQFkeenTIDGEFRLnktdtKPVKLMIQKakFHFSFIeeanCKVLEMPYEgedLSM 285 great blue-spot...
XP_004628459 149 AQnsidefcRLLLINAVYFKGTWKETFlkqsTRTVPFKMnkneqRPVQMMFQKdtFPWAHVsevpAQVLELPYQgqeLSM 228 degu
NP_956230    150 AEgsvdslsRLVLVNAVYFKSSWERKFleehTHEQQFRTsrnesKPVQMMFQKgrFPLAFIpdvnCQILELPYAgkeLSM 229 zebrafish
XP_008295863 251 AKdavngltKLVLVNAIYFKGQWNQKFneeeTIDSVFKTskndtKEVKMMRLTstFPIAVVpefgCRVLEMPYKgkaLSM 330 bicolor damselfish
XP_020792369 177 GKgavdsaaKLVLVNAIYLKADWEKQFekerTEDAKFRLnkrqtQTVKMMHQSgdFMLRKVkeisCQVIEMFYTc-eLSM 255 great blue-spot...
AAH54232     149 PVgavdsltRLVLVNAIYFKGNWANKFnpehTHEMPFRLnknetKPVQMMYKKakFPMTYVgelfTKVIEIPYVdneLSM 228 African clawed ...
Feature 1                                                                                        
1XQG_A       243 FILLPKDvedestglekiekQLNSESLSQWTnpstmanakvKLSIPKFKVEKMIDPKASLENLGLKHIFsedtsdfsgms 322 human
2DUT_A       270 FILLPDDikdgttgleqlerELTYERLSEWAdskmmtetlvDLHLPKFSLEDRIDLRDTLRNMGMTTAFttnadfrg-mt 348 chicken
2ARQ_A       232 FLLLPDEiadvstglellesEITYDKLNKWTskdkmaedevEVYIPQFKLEEHYELRSILRSMGMEDAFnkgranfsgms 311 human
1UHG_A       242 LVLLPDEvsgle----qlesIINFEKLTEWTssnvmeerkiKVYLPRMKMEEKYNLTSVLMAMGITDVFsssanlsg-is 316 chicken
XP_020792381 286 VILLPNDiedettglekleeDLTYDKFKEWTdrdtmgfvevEVRLPRFKMEENYDLNKVLISMGMVDAFdvgksdlsgms 365 great blue-spot...
XP_004628459 229 VLVLPDEgvdls----tvekTLTLEKFQTWTspehmkrtdvQVSLPRFKLQEDYDMVSVLQGLGVVDVFdphkadlsgml 304 degu
NP_956230    230 LVLLPNAmeddgtgleklerALTLETLTDWTrsdmmdvlevEVSLPRLRVEERLELKPLLVELGMPDAFdpqradfsgvc 309 zebrafish
XP_008295863 331 LILLPDQieddstgleklekELTYEKFMKWTgpgmmnetliEVGLPRFKLEEMFDMKDILVSMGMVDAFdpvksdfskms 410 bicolor damselfish
XP_020792369 256 LIFLPNDikdsttglekleqRLTYKSFVEWTrrdkmtlykvDLRLPRFRIEQNYELNEVLKTMGMEDAFdhckcdfsgms 335 great blue-spot...
AAH54232     229 IILLPDDindgttgleklekELTYEKFLQWTnpemmditemELSLPKFKLEDDYDLESLLSKMGMSDAFdqgradfsgms 308 African clawed ...
Feature 1                          #  ###########               #######                   
1XQG_A       323 etkgvaLSNVIHKVSLEITedGGDSIEVPGARilq---------hkdELNADHPFIYIIRHNktrnIIFFGKF 386 human
2DUT_A       349 dkkdlaISKVIHQSFVAVDekGTEAAAATAVIisftts---vinhvlKFKVDHPFHFFIRHNksktILFFGRF 418 chicken
2ARQ_A       312 erndlfLSEVFHQAMVDVNeeGTEAAAGTGGVmtgrt-----ghggpQFVADHPFLFLIMHKitncILFFGRF 379 human
1UHG_A       317 saexlkISQAVHAAHAEINeaGREVVGXAEAGvdaa-------svseEFRADHPFLFCIKHIatnaVLFFGRC 382 chicken
XP_020792381 366 pandlvVTKVVHKAFVEVNeeGTEAAAATGVIisera-----aliteKFIVDHPFLCYIRHNpsksILFAGRF 433 great blue-spotted mud...
XP_004628459 305 adrnlcVSMFVHKSVVEVNeeGTEAAAASACKigycc-----arywkVFCADHPFLFFIRHNktnsLLFCGRF 372 degu
NP_956230    310 aggellLSTVVHQSFLEVNeeGTEAAAATAAVmmtrc-----lmraeRFCADHPFLMLIRHNptgsLLFYGRV 377 zebrafish
XP_008295863 411 pkrdlvLSKAVHKAYVDVNevGTEAAGATVAIvaer-------alaeSFKADHPYLFFIRHNpsgtILFAGKF 476 bicolor damselfish
XP_020792369 336 pakdlmLSQAVHRAVVDVNeaGTEAAAATAAYmmlkcslmyipppraTFNADHPFIFFIKHIptdtVLFAGRF 408 great blue-spotted mud...
AAH54232     309 gcndlfLSKVVHKSFVDVNeeGTEAAAATAAImmlrc-----amripRIVCDHPFLFYIMHRqnhsILFCGRF 376 African clawed frog

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