Conserved Protein Domain Family
DUF4524

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pfam15025: DUF4524 
Domain of unknown function (DUF4524)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 197 and 638 amino acids in length.This is the N-terminal domain of the member proteins. The human gene is from C5orf34.
Statistics
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PSSM-Id: 464454
Aligned: 22 rows
Threshold Bit Score: 108.174
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_026692355  20 VLIFNDDSVEVQFKD--------------RSVLQLSPCGANYQYHQPSTDGLRLVENLNTIRQRSKFATSDTKTQVDFAV 85 
XP_002593083  10 LLLLCNDQVQAHFSD--------------GSRLQLSPCGSVFVCETPPNPAQHALQGVRRVQQRTRFVTSEFRSRVLQAL 75 
CBN76130       7 CLLFENGAALAVFGDdgdhhtrqsgdergNSAVVLEPSGACFAEVRQD---------GTCHRQLSDFCRRDLIPHVAAVS 77 
XP_002505862  73 GIIFDDGAVKCTFSD--------------LSSIVLDPTGQYFTAHDAS---------GETARQLSEFAISRFAPRLRASL 129
XP_001692047  14 VCILADCRTKATFSD--------------NTILSLNSTGSSFLVTTPD---------GRSTRQLSEYALARHSPLLAAVL 70 
XP_002957261  12 ICVLDDGRAKAIFSD--------------NTIIVTNSTGSAFIIRTQD---------GHLMRQVSEYALTRHCPLLAAVL 68 
EDO34867       6 AVLLKDDSFYARFSD--------------GRVLQLSPCSSTYLFTR---PSCHP----ASVQQYTRFAVSEFRKSVVAAV 64 
XP_002111820  19 TIVYCNGMVEARFCD--------------GLAMTLSKCGNYTTILNHS----MPFSNNKAIKQMTRFATSRNQKKIHYMI 80 
2_pfamImport   1 MVMYEDESIDVRYRN--------------GAHLQLSPCGCEFMLAKPSDPSGHPLQPIGRVRQRTRFTISTYKELMVAAL 66 
XP_023199774  10 MVMYEDESVEVHYRH--------------GAHLQLSPCGSEFVLVKATDPLGHPLQPTERVRQRTRFTISAFKALMATAL 75 
XP_026692355  86 SVRNLFAVGPYIAaefHHLCEGV-----VRLHQDVTD-------------YVWPv-------vSEknPTDGSIVVDTDGK 140
XP_002593083  76 EFRNRFCERPYLC---QELVQPEr---vLNSCCDLTQ-------------TKWP---------STvnNNNNNTTTQDAGS 127
CBN76130      78 SFRNAHSPRPYLSqriHATLEQEt---hSSNGTSSSSsrrrrrrrtpsriAHWPaaaeptcrhSTsnSSSTFVVRGADGS 154
XP_002505862 130 EFRNTHVEVPYCPpcvTKPAASEvpprsFRVGRKILH-------------ARWSe-------sAAeaEAGGHLTRLDGGG 189
XP_001692047  71 EFRNMHVELPCFCkplARVLRSS-----FALGYLVQD-------------ATWPs--------PSvaLSAGLAQLQPDGK 124
XP_002957261  69 EFRNMHVDLPCFCkplARVLRSG-----FTLGYVIRD-------------ATWPt--------PShaIAEGLAQVQPDGK 122
EDO34867      65 TFRNQFAERPYVC---KELLDDAk---sLVNYDDAST-------------CAWP---------VT--IIPDFVAKEINGS 114
XP_002111820  81 KTRNLYTLYPCCG-----ISNPEh---kEIKNRYSPI-------------AIWP---------KA--SGHPHVKRNSNGS 128
2_pfamImport  67 TFRNKYATRPYLP---EELILVDh---kKPFFSLDSE-------------VQWP---------EW--SSCDGDLAP-GVQ 115
XP_023199774  76 AFRNKYASRPYIP---GELISADn---rKPFYSIDSG-------------VKWP---------EC--SSYKPEFGP-GGE 124
XP_026692355 141 VTVCAKNDAAELVLWACQNQVEVKLCVKLN 170
XP_002593083 128 VTVTSLDNLATLCLAPHGKEFTVTFLCRII 157
CBN76130     155 VEVRAAGGNARLALSASGTVAEVDYAVALP 184
XP_002505862 190 VALESIDGIARVVLSAHGLMAHVTFPVLFA 219
XP_001692047 125 VAVSSEDGVAQVVLHSHRRRFAVCYPLLVA 154
XP_002957261 123 VALSSEDGVAQIVLHRHQRRFAVCYPLLVA 152
EDO34867     115 VKVHSLDRKAQLLLAPHRQSFTVGFLAQIS 144
XP_002111820 129 VTVTALNNAATLILKNHQQSFTVKFIAKCI 158
2_pfamImport 116 TIIGAEGGRAVLMLSPSGEEFCVEFTCILS 145
XP_023199774 125 IVVRSEEGRAVLTLSPSGEEFSVEFACNLS 154
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