Conserved Protein Domain Family
TASL

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pfam15133: TASL 
TLR adaptor interacting with SLC15A4 on the lysosome
In humans, TASL (TLR adaptor interacting with SLC15A4 on the lysosome) is encoded by CXorf21 that is associated with systemic lupus erythematosus. It is an immune adaptor that is required for recruitment and activation of IRF5 by TLR7, TLR8 and TLR9, in mechanistic analogy to IRF3 and its three adaptors STING, MAVS and TRIF. TASL interacts with the endolysosomal transporter SLC15A4 forming the SLC15A4-TASL complex, which is required for endolysosomal TLR signalling. TASL contains a pLxIS motif that is important for its function.
Statistics
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PSSM-Id: 434486
Aligned: 15 rows
Threshold Bit Score: 322.442
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006008195   1 MLSETFLCAIPYLqEDENGA--------------TPHCESI---QGKRMHEMTSLCDNTDSPNGTTQSRSlFKRYRSLGR 63 
XP_003218959   1 MLSEGYLYGIPYL---------------------DLLNHELchkQEESARELKSLNGIIYESAKEANDKT-FWSCRSVGK 58 
XP_003640560   1 MLSEGYLYRIAYLcEDS-----------------ELCTNQA---VEEVVYEMRSIN---CSSRDEAQVKSlLQRCRSAGK 57 
XP_002191807   1 MLSEGYLHRITYLwEDLQ----------------PALYESL---PDEGVYEMRPIN---YSSTVEAQGKSlLQRCRSAGK 58 
XP_006002453   1 MLGEGFLLGIGY--EQDKHHrqlapydcqnsrkgCARQDSW---ENLAEDFILVDDAMSKVQVMEGKSQS---------- 65 
Q8BHV4         1 MLGEAFLTKFLY--KEQRHAklykp-----lrckKTSNDKK---ENWENKLLDTPDNSLSPLKTGSQEKV---------- 60  house mouse
XP_002186712   1 MLAEGILTRLIY--KESCHQdkpc-------kspASQKAKE---GIWRQKLVDNPEIKGFADGCEKREEL---------- 58 
XP_004940775   5 MLAEGILTRLIY--KDICHQdkph-------kshAAKKDKE---GIWREKLGDDPKIKGSEDGRENLDKI---------- 62 
XP_021122503  61 MLAEGILTSLVY--KESCHQdkph-------kshAAKQDEE---GNWREKLVDNPKITGLADGCETQDGI---------- 118
XP_005475563   1 MLCEGRLLIMTYCeFED----------------------------------LDSLPSKPAFQNAYGSQKTaAALIPGSTR 46 
XP_006008195  64 LVTSLRPEEGREYRKEVFTQPGRNKvp------------eRQLSPVVDIPRGSSVSK-ETYLVPS-SCKSICKNYNDLHI 129
XP_003218959  59 LIYSVCSKENRNSRKQKTTLAQTNQnpl----------feHRSSAALDISMGYGVNG-DTYLVPP-SCKSICKNYNDLHI 126
XP_003640560  58 CISAVHSRGSKHSRRQKDNLQQSVQnpl----------peGQTSPTMDVCEG--LVRkDTYLVPS-SCKSICKNYNDLHI 124
XP_002191807  59 RISSVCSRGSKHSRRQKDNLPQPVQhpm----------ptGQPPPATHVCEE--PTKkVTYLVPP-SCKSICKNYNDLHI 125
XP_006002453  66 -APDIKESKLENVLQYQLTQEELKKdcpra------siltKQTSDAVPVPRSYQHIEpHLDLYTSwSCKNIYWNYPDLHI 138
Q8BHV4        61 ---IEGSVTEQDNDSSQIKSMDELPvakck-----ctplpGNVSVALPIPKRGQ-EEtQLDLYRSwSCTSICQNYPDLQI 131 house mouse
XP_002186712  59 ---SARSSEVEAGSCPRWGSVEKEPardqe------mlvkGTASPALHIPRRGGSLD-QVDLYRSwPCNSIYQDYPDLQI 128
XP_004940775  63 ---SAASNKIENKNGLQQRSTTELPaknqs------tavrRIVSRALHIPEREQSNE-QTDLCRSwSCNSIYQNYPDLHI 132
XP_021122503 119 ----SAKSDMEHKRDPQQRPILGFPardqk------tlvkGTVSPALHIPRREQYNE-QMDLYRSwSCNSIYQNYPDLHI 187
XP_005475563  47 HAPLVHHNSPEQMATDNRRASAELYisplqsldlqrahlgRQISREIEIPAQAHSGGdTPFLVPS-FCQSICKNYSDLHI 125
XP_006008195 130 AGDQVMPIGSKSTDFTYDSSFDFcdGPFLQSSEIPPPL-ESLKSSK--EFLSRPTGP------DSSLWRGGSIRYKSII- 199
XP_003218959 127 AGDQVLPMSSVKRDFTYNSGI----GPFLESSEIPPPI-ESISLPPa-DNPPKPVQG------YSSCWRVASIM------ 188
XP_003640560 125 AGDCVVPISSVATDFTCDSGI----GPFLESSEIPPPM-ESVRVPPs-ETGRKQAQG------FSSCWRVASLV------ 186
XP_002191807 126 AGDYVVPISSVTTDFACDSGI----GPFLESSEIPPAM-ESVKAPPasDTIRRPGQG------HSSCWRLASLG------ 188
XP_006002453 139 GGDHVGDIDTSDVLYVTERELQNcdGPILHSVDMDPA--------------SSPPRSclenhqAAVVANAEEVPEKGFP- 203
Q8BHV4       132 GGDHIR-NMYDSGCFVEHTYDDVcnGPLLLSVDIPLG-----HSPKm-EPLEKTSTS--------KLFNGDEIREKSML- 195 house mouse
XP_002186712 129 GGDRVGGHTCDSGCVLDHVCDELpdGPVLLSIDIPLG-----QSPQ----CEHPKKP------SGMSLPGDEAGERSLV- 192
XP_004940775 133 GGDHVGDHTCDSGCVLDHVCDELsdGPVILSVDIPLG-----QSPL----CEHPEKP------GVNFLSGDEAGEGSMM- 196
XP_021122503 188 GGNRVGDHTCDSGCVLDHVCDELpdGPVILSIDIPLG-----ESPL----CEHPDKS------GSQSLPGDDAGERSIM- 251
XP_005475563 126 AGDQVLPLSANNCELRVCADVPDv-GPFIQSCDVPPAVeDSLQGHEarDGRLFPLRG------GSNRWRLGSGRDRSFFl 198
XP_006008195 200 -QGLQPLSNSMLNDYLEQKVLELYKQYLMDSMVNSASPTK---------IMASELIMNNLDQITLQISKEQNMETTKAKD 269
XP_003218959 189 -QHQQPLSNSILNNYLEEKVVELYKQYIMDGMGSSASPTH---------ILASEFIMTNVDQISMKLTQEKKMNSTIAKD 258
XP_003640560 187 -PHQQPLSDSALNDYLEQKLMELYKQYIMDSTVNRASPTQ---------ILASELIMTNVDQISTQISRERKMETTKAKD 256
XP_002191807 189 -PHQQPLSDSALNDYLEQKLLELYKQYIMDSTANRASPTQ---------ILASELIMTNVDQISMQISRERNMETVKAKD 258
XP_006002453 204 -LPKQPLSNSILNNYMEEKIIELYKQYLEDSLSRNASPTQ---------ILTSSFVLHNVHQLSLHISQEQNMETTRAKE 273
Q8BHV4       196 -LHKQPLSNSMLNNYIERKVDELYKQFLEENLTRCLSITN---------LMTSSILMNNVNQISLQISQEQNIEASKARE 265 house mouse
XP_002186712 193 -LSEEPLSNSTLNKYMEAKVAELYKQFFDESLARCGSITN---------LLTCSWIRNSLDQISVQISQEQNIETSKARG 262
XP_004940775 197 -FCEEPLSNSLLNNYMEAKVSEIYKQLFEEILTRCGSVRN---------LLTCSLIRSNVDQISFQISQEQNIETSKARE 266
XP_021122503 252 -LCEEPLSNSMLNNYMETKVAEFYKLFFEENLTRCGSVRN---------LLTCSLIRNNLNQISFQISQEQNIEASKARE 321
XP_005475563 199 qGHEGPFSNSLLNHYLEQKLLDLYQQYMMENMAREGAPGSdsdtsaicpLLGSELVLTSLDQITLQLSREGNMEAGLAKD 278
XP_006008195 270 MVISCL----LRVAsgkqSTELSTPNLQISSD 297
XP_003218959 259 MVINCL----LQLAsgkvSTEMSTPSLHISQF 286
XP_003640560 257 IVISRF----LQIAseqiFSEISTPSLHISQY 284
XP_002191807 259 IVISRF----LQIAsgkvSSEMSTPTLHISQY 286
XP_006002453 274 MVLNCL----FSVVsg-nSSEFSTPNLQISHI 300
Q8BHV4       266 ALLHSLalcnLRNVshrnSTELSTPNLQISNQ 297 house mouse
XP_002186712 263 ALLHSLalfsSRNApnrnSSEFSTPNLQISNI 294
XP_004940775 267 VLLQSLalfsLHNVtsrsSSEFSTPNLQISNP 298
XP_021122503 322 VLLQSIalfsLHNTtnrsSSEFSTPNLQISNP 353
XP_005475563 279 MVLSCF----LRVAgdmqSSEISTPFLQISNE 306
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