Conserved Protein Domain Family
SLC5sbd_SGLT4

?
cd11488: SLC5sbd_SGLT4 
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain
Human SGLT4 (hSGLT4) has been reported to be a low-affinity glucose transporter with unusual sugar selectivity: it transports D-mannose but not galactose or 3-O-methyl-D-glucoside. It is encoded by the SLC5A9 gene and is expressed in intestine, kidney, liver, brain, lung, trachea, uterus, and pancreas. hSLGT4 is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5 )transporter family.
Statistics
?
PSSM-Id: 271380
Aligned: 3 rows
Threshold Bit Score: 1099.99
Created: 18-Jul-2011
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
Feature 1: putative glycosylation site [posttranslational modification site], 1 residue position
Conserved feature residue pattern:NClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on site mutagenesis and examination of partial transcripts of rabbit SGLT1
  • Citation:PMID 1903656

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
AAI04858      37 DISVVVIYFVFVIAVGIWSSIRaSRGTIGGYFLAGRSMSWWPIGASLMSSNVGSGLFIGLAGTGAAGGLAVGGFEWNATW 116 human
AAI15269       1 DIAVVVVYFVFVLAVGIWSSIRaNRGTVGGYFLAGRSMTWWPIGASLMSSNVGSGLFIGLAGTGAAGGLAVGGFEWNAAW 80  zebrafish
XP_002931459  21 DIIVVVVYFVFVLGVGIWSSIRaSRGTVGGYFLAGRSMTWWPIGASLMSSNVGSGLFIGLAGSAAAGGLAVGGFEWNASW 100 western clawed ...
Feature 1                                                                                        
AAI04858     117 LLLALGWVFVPVYIAAGVVTMPQYLKKRFGGqRIQVYMSVLSLILYIFTKISTDIFSGALFIQMALGWNLYLSTGILLVV 196 human
AAI15269      81 VLIALGWIFVPVYISAGVVTMPEYLRKRFGGqRIRIYMSVLSLILYILTKISTDIFSGALFIQVSLGWDLYLSTVILLAV 160 zebrafish
XP_002931459 101 VLVALGWIFVPVYIASGVVTMPEYLKKRFGGkRIRIYISVLSLILYIFTKISTDIYSGALFIQVSLGWNIYLSTVILLAV 180 western clawed ...
Feature 1                                                                   #                    
AAI04858     197 TAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGWYpGLEQRYRQAIPNVTVPNTTCHLPRPDAFHMLRDPVSG 276 human
AAI15269     161 TALYTIAGGLTAVIYTDALQTVIMVIGAFVLMFIAFDKVGWYeGLLVQYEKAAPALTVPNTTCHLPRSDAFHIFRDPVTG 240 zebrafish
XP_002931459 181 TAIYTIAGGLTAVIYTDTLQTVIMVAGAFVLMFISFEKIGWYpGLEQKYMEAIPKITVANTTCHLPRADAFHIFRDPLTG 260 western clawed ...
Feature 1                                                                                        
AAI04858     277 DIPWPGLIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMISRALFPDEVGCVDPDVCq 356 human
AAI15269     241 DIPWPGLIFGLTVLATWVWCTDQVIVQRSLSAKNLSHAKAGSVLGGYLKVFPMFFVVMPGMISRALYPDEVACVDPDECq 320 zebrafish
XP_002931459 261 DLPWPGLIFGLTVLATWVWCTDQVIVQRSLAAKNLSHAKGGSVLGGYLKILPMFFVVLPGMISKALFPDEVGCVDPAECl 340 western clawed ...
Feature 1                                                                                        
AAI04858     357 RICGARVGCSNIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRKSTEQELMVVGRVFVVF 436 human
AAI15269     321 KICGAKVGCSNIAYPKLVVELMPVGMRGLMIAVMMAALMSSLTSIFNSSSTLFTMDIWQRIRPRASEKELMVVGRVFILL 400 zebrafish
XP_002931459 341 KYCGVEVSCSNIAYPKLVITLLPVGLKGLMIAVIMAALMSSLTSIFNSASTIFTLDVWLRIRRNAKEQELMIVGRVFILI 420 western clawed ...
Feature 1                                                                                        
AAI04858     437 LVVISILWIPIIQssNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGVGLLRMILEFSYPAPACG 516 human
AAI15269     401 LVALSIVWIPVIQtaNSGQLFDYIQAITSFLSPPITTVFIMAIFWGRVNEQGAFWGLMVGLVVGMVRMIMEFVYGTPSCG 480 zebrafish
XP_002931459 421 LVVISILWIPIIQaaNSGLLFDYMQSVTSYLSPPITAIFILAIFIKRVNEPGAFWGLIIGLLVGLTRMIMDFVYQAPSCG 500 western clawed ...
Feature 1                                                                                        
AAI04858     517 EVDRRPaVLKDFHYLYFAILLCGLTAIVIVIVSLCTTPIPEEQLTRLTWWTRNCPLSELEKeahestpeiserpagecpa 596 human
AAI15269     481 ETDLRPsLLKDVHYLYFALILLALTVLIITAVSLCTAPIPEKHLVRLTWWTRHSKEERVELedpwakpagsdls------ 554 zebrafish
XP_002931459 501 EEDLRPsVLKDVHYLYFAIFLFGLTAIVCVVISLCTPAIPEQDLARMTWWTRNSPIYKEDLendlqqepdpaeiptiipv 580 western clawed ...
Feature 1                                                                                        
AAI04858     597 g--------------ggaaensslgqeqpeapsrsWGKLLWSWFCGLSGTPEQALSPAEKAALeqKLTSIEEEPLWRHVC 662 human
AAI15269     555 ----------------------ttesegsdedapaWWKRAGMWLCGLSQTTKQDLTEEERQALekKLTSIEEDHMWKTVC 612 zebrafish
XP_002931459 581 iekepagpsipavdvlqnssvvedqkekhevakfsWWKKLYFWFCGISIHPEVKLSSEEQKRLqrKLTSIEEKPLWRYIC 660 western clawed ...
Feature 1                           
AAI04858     663 NINAVLLLAINIFLWGYFA 681 human
AAI15269     613 NVNALILLTANVFLWGYFA 631 zebrafish
XP_002931459 661 DINALILLAINVFLWGYFG 679 western clawed frog

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap