Conserved Protein Domain Family
DUF4641

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pfam15483: DUF4641 
Domain of unknown function (DUF4641)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 201 and 519 amino acids in length.
Statistics
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PSSM-Id: 464741
Aligned: 18 rows
Threshold Bit Score: 467.686
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_004777306  80 EGRPGSRADDKg-dAPD--YaahladESaADIVQQLTDRDALGLRRNPSPESCAAEASG-GWAGLDAGPSGRGALV---- 151
XP_017205159  95 EARPTTPASDGe-gPVD--Smsq-vaEAcAAIVRLLSDPDAGALSRFPDAESTCAETGA-ICVRFEADASSKAMLD---- 165
XP_008271008  97 EARPKSPTTDRq-gAVG--Pavq-faEAcAAILEPLSVSMARGL---PGVGRGATEAAA-AWAPVKASISGRGGLG---- 164
EGV91497      80 DENPDSPVEDKv-vGLD--FlsptsvDT-VAIGQPVSTLESPQVGEQASPEGICVEPEP----EMEPGPSRRGLQAsgsg 151
Q9D454        79 EERVGSPMDEKv-vGLD--FlsqpsvET-TATGQQVTNLETKGAREHPSPESVCAETEA--------GSIRRAPQA---- 142 house mouse
EGW13498     102 AGPTSSPVGQEeggEVSgyFlpqlsiEA-MTIMRELTDLQARKFCRYPSPQSCAAELTA-LWSSIGEGS-NRGAEP---- 174
NP_001346600 102 EGGATSPVDQEeevDMD--FlpqlsiEA-MTVMRELTNLQLRKVCRYPSPRTCAAELAA-LWGNVDEGS-NRGALS---- 172
A8MYA2        81 EGRPGTPVDDQg-dVVD--YsfyladEP-AAIVPPPS------VQGHPFPEGAAAEGSAeNWADAEVGPSGRDVLG---- 146 human
XP_017823775  83 EAPPGNPVDDQr-dGVE--YssclaeEP-AAIVPPTS------VQGHPSPEGAAAKGSAdNWAGPEVRPSERGLLG---- 148 white-tufted-ea...
XP_017457806 102 ECQTTSPIDQEe-vDLD--FlpqlsnEA-MTIMRELTNLQTRKVCRYPSPQTYAAELAA-LWENIDEGS-NRRALS---- 171 Norway rat
XP_004777306 152 --------LGRVESQPPSAAAgLRVAGPEGSRAWGNPRRGAKSRAN-ARADRQRPSaataataEGLGAPLPSDPESSDEF 222
XP_017205159 166 --------PSSVETLQACAAP-PYMSASGTGQIWDSRKRRVDRSHLsISMIVQRAC-------RDGLVGLPFRLTSSDDL 229
XP_008271008 165 --------LSCAESLQRSAAP-RPVSAFRKGRDQGHSKTRSARRRLiFTTDEQRTG-------TKGWLQLPSDSESSDEF 228
EGV91497     152 ygsgsgsgSGSEEAKSASATS-LFPKGLEHSRAWVTPRKNPAGRGV-MGEDPHLSI---------------PEPELPEEL 214
Q9D454       143 ----------SEEAKFAASAGtFFPKGLEQSRSWVTPRKSTTSRMV-IGENVHHPT---------------SEPEPLDEL 196 house mouse
EGW13498     175 --------VSSGEGKQVSTGS-LYPRGLGRSRAWVTSRRGTTSKMV-RSEAVQRST---------------SKP-ASDES 228
NP_001346600 173 --------PSSVRGKQGPEGA-LYPRGLGRGRAWGTPRRHTIGRMV-SSEGVHYPS---------------SNPVSSDEF 227
A8MYA2       147 --------HSPGKWQQASAGR-LHLCGPGPVRAWKNPERGSKSRWS-LRVDPQQPSa------KGPTRLPTHDSDSADES 210 human
XP_017823775 149 --------PRPGKRHHASARP-LHLTGPRAGPAWQHLQRGSKSTWR-VRVDLQQPSa------KGPAVLSVEDSDSTDES 212 white-tufted-ea...
XP_017457806 172 --------LSSVKGKQAFEGA-PYPRGLGRGRAWVTPRRGTISRMV-SSEVVQYPS---------------SNTVSSDEL 226 Norway rat
XP_004777306 223 GEIQLMRVSIYSKE---GGQAKPSSPEDPGDTPRHSNFRIRENFLHVPGPFLTSAPRGFTSVVERQAIGELDMPSSKKMQ 299
XP_017205159 230 GIMQPRRVSIPQER---RGLFKCSSSETLVGNPRCSIFLSRENFPHISVRLLTSTLWGFTWTMERQRVREVASIISKKMQ 306
XP_008271008 229 WDVQPLRVSPRLER---RDRTKDHSSEEPPESPIASTSHGGENFPHISVPFLTSTLQGLTKAMEMQGMGELGPSSSKKVF 305
EGV91497     215 NEMQMMRVTICLKD---GVQSKTCGPAETPEVARPTNVQNRDSLIRMSSSLLTSTTRGLAPSLERQASKELEGFSSKKKA 291
Q9D454       197 NEVQMMRVTICLKDgnhGNQAKNSGPAETGDLARHSNVQTRDSFMRMPSSLLVSTTRGLTSGVERQASKEPEPFSSKKKQ 276 house mouse
EGW13498     229 SDSQTMKVTICLKE---GNQAKSSGRTELEDSGKHTNVQGRGRFVHVPPSVLSSATRRFSAGLEKPVSGEPEGSLCKKRQ 305
NP_001346600 228 SDTHVMKGTAGLKE----DQARSSGLTELDNIARHTNVRGRGNFVHIPPSVLSSATWGVSSGMERQASGEQESSLAKKKP 303
A8MYA2       211 SDLPLMKVGICRNE---GSQAKPGSPKKRADTSRQASFHCKESYLPVPGRFLTSAPRGLTPVAERPAVGELEDSPQKKMQ 287 human
XP_017823775 213 CDLRPMRVGIHRNG---GSQAKPQSPKKTAGARRHR----RQSFSLVPGPFLTSAPRGLTPLVERPAVGELENSPWKKIH 285 white-tufted-ea...
XP_017457806 227 SDTQVRKVTTCLKE---GDQARSSGLTELDNIGKHTTVHSRGNFVHVPPSVLSSATWGLSSGMERQASAELESSLFKKKP 303 Norway rat
XP_004777306 300 -SVVWGKGESRPTYRGATAVAat----------aAAAAGGLPRATSRRKVTQEKKSLGGPSRVTSGKSFPSWGQRVSAAP 368
XP_017205159 307 -S----DGEGRPSCLGAGAAA-------------ASGAGGLPHATPKKELVQKQKSLGIDTNVVLGTAFAPWGHRESIAP 368
XP_008271008 306 -SGLPGKRGGSPTHPGVPAAP----------------AGSLPQATSRKKEAKEKKPLVVCPEFVLGSAFAPWGQRASAAP 368
EGV91497     292 gGALWGKGAAKPSYPDA------------------PVASVLPKASPRKKMTPKKKPLWDASTVTLGRAFHQWGQRLKSAP 353
Q9D454       277 -GTLWGKGGSKSSYPEA-----------------AAGIGALPKASPRKKMAQKKKPLWDASAVTLGRAFHQWGQRLKSAP 338 house mouse
EGW13498     306 -SMVWGKEGSRPGYPGASAASvstaaansaaapaPVASGALPKTNTRKKTAQEKKSLSDASRGPLGRTFPPWGQRLKSAP 384
NP_001346600 304 -NMVWGKEGSRPSHHGVTAAAatasaa--apasaSTASGALPKTSPKKKQAQEKTSSSDVSRGYQGKNLPTWGQRLKSAF 380
A8MYA2       288 -SRAWGKVEVRPSCSGA------------------AAAGALPQGLSRRKMAGGKKSLGGASQLALGRGFPACGERLSAAP 348 human
XP_017823775 286 -SRARGNVEVRPSYSGA------------------ATAGALPRGPRRRKTAQEKKSQGDASQLALGRALPICLERLSATP 346 white-tufted-ea...
XP_017457806 304 -NMGRGKEGSRSSHQGATAAAattsaa--apgspSAASGALHKTSPKKKQVQEKNSSLDVSRGPQGRNLSPWGQRLKSAP 380 Norway rat
XP_004777306 369 LEPATFPPISGVPLLGKSKKHSVGPWGIKQPKHTG-AGKKSVARRTREAEVVasAGEGTDSSRDAFPKGQ-----LP-KQ 441
XP_017205159 369 MASVSFPKVS---LPEKSSMVSLLHGGSKKSSQGC-ARKKRGTRRKRDFQAV--VRGDGGLSRDPVPKTQ-----LP-AH 436
XP_008271008 369 GYPVTFPKIPGISLLEEPDTSFSLPWVHKQSQQGD-TGKDSAARRKS--QPV--AA-DRGPDRDPDSGAQ-----FP-AD 436
EGV91497     354 AEPATFPPISGVGLPGRSNKCSLLPLRPKQCKNFY-TGKRSGAKRTRDLQVA--AKEDTELARDPCSQGA-----FS-TH 424
Q9D454       339 AEPATFPPISGVGLPGRSNKCSLLPLRPKQCKNLY-TGKRSGAKKTKELQLV--AKEDTDSTRDPSSQVQ-----FP-TH 409 house mouse
EGW13498     385 VEPATLPPISGVALIGKTSKNS-LPSGPKDCKPFC-TGKRSMARKTKESQPG--AKEDDDQTRNPGLQAQ-----LP-TH 454
NP_001346600 381 EGPTTLPPISGVALLGKASKCS-LPSGPKEFKSIC-TGKKSIAKKTREPQAG--PKEDN-SPRDPGLQAQ-----VP-PH 449
A8MYA2       349 PEPATFPPFSGVRPQGMSKK-------PQKPKHSS-PGKKPAGRKTRESQAA--AREDNDPNRDEVPRAQ-----LP-TH 412 human
XP_017823775 347 QEPATFPPFLGVRxQGMSKK-------PQKPKHSSpTRRRATGSGTRESQAA--AREDNDTHREDIPGAQ-----VSrPF 412 white-tufted-ea...
XP_017457806 381 VGLATLPPISGVALLGKASKCS-LPSGPKECKPFC-TGKKFMVKKSRETQAG--PKEDNNSPRDPGLQAQifvceVP-PH 455 Norway rat
XP_004777306 442 RPGPSCLCMHRGECSTGDLQARAPQVPGSSEPLAPSQGDVLPRG-PAPSGDQEPLDQPPRPE-RQQPPPAGAQDCPRCLV 519
XP_017205159 437 MAGTSSQSSHRGEFSSGNPNTRDHPVGANWQPLSPSWGDIIPRS-PALSGDLELPVLPRRT--ERPQLPPGIEGCPKCVV 513
XP_008271008 437 KPGTPCKYVPGGEFSSGERNRRQLQDSENLEASSLSQGSVTPRG-PALSNDQEPPVRPRRP--ARQQLPPGIEGCSRRTM 513
EGV91497     425 RAEAPSQSGHQ-EFSSGDISSRSLQDPANSPSSTLSQKGA-PRR-PAPSGDQELPLGSSPPDpEVQH---GIPCCPRCPE 498
Q9D454       410 RAEPPCQSVHQ-EFNSGDINARSLQDAGNSQSSALNQRGIMSKK-SVLSGDQEEPVGLPAPDsEILQLP-GTQGCPRCPE 486 house mouse
EGW13498     455 RAEQPSTCTNRREMTSGDANFRAPQVPGHSQLLTLSQRSSRSRA-LAPAGESLGF--------QSSEERQGMEGNLRLCS 525
NP_001346600 450 RAEQPSVCMYRGEMSRGDFNIRAPQVPANPQFFSLSQRCARPRApPAPAGEQNQLMDPIFPNeESQQVIHGTPGCAQCEM 529
A8MYA2       413 RPGLPRLSVRRGEFSSSDPNIRAPQLPGTSEPSAYSPGGLVPRR-HAPSGNQQPPVHPPRPE-RQQQPP-GAQGCPRCIW 489 human
XP_017823775 413 SP--SSPCMHCGEFSSGDPNIKPPQVPGTSEPSAYSLGGLLPRR-RAHSSDHQPAVHPPTP--ERQQPPPGAQKCLRrss 487 white-tufted-ea...
XP_017457806 456 RAEQPSVCMYRGEMSSGDCNTRASQVPGNLQFLSLSQRCPRPRA-PAPAGEEDAIVGAVLPGeERQQELQGTPGCAQCLM 534 Norway rat
XP_004777306 520 L----------------QREIDDLKEQLAAMRS 536
XP_017205159 514 L----------------QKEIEDLRKELGLLNP 530
XP_008271008 514 L----------------QKEVHDLREQLAVVRS 530
EGV91497     499 L----------------QKEIENLKKQLWALQA 515
Q9D454       487 L----------------QKEIEDLRKQLSALQA 503 house mouse
EGW13498     526 FgglqpcslgfpvwvgrESTGDWVQAVLASGHI 558
NP_001346600 530 L----------------QKEIDELKEQLGLALL 546
A8MYA2       490 L----------------QREIEDLTQQLAAMQF 506 human
XP_017823775 488 aygyrgkltvlqss------------------- 501 white-tufted-ear marmoset
XP_017457806 535 F----------------QKEIDELKEQLGLALL 551 Norway rat
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