Conserved Protein Domain Family
NYD-SP12_N

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pfam15015: NYD-SP12_N 
Spermatogenesis-associated, N-terminal
NYD-SP12, also known as SPATA16, is a germ-cell specific participant in the Golgi apparatus, and its expression is confined to spermatogenic epithelium, not being found in interstitial cells. Computer analysis of the protein-sequence showed that NYD-SP12 contains a cluster of phosphorylation sites for protein kinase C as well as for cyclic nucleotide-dependent protein kinases. It is postulated that since the mutation of some Golgi apparatus' proteins are responsible for male infertility that NYD-SP12 might play a role in modification and sorting of acrosomal enzymes. OMIM:102530.
Statistics
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PSSM-Id: 464447
Aligned: 5 rows
Threshold Bit Score: 1030.27
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9BXB7         5 SSRSLENAVNRIYHDQLV--PKINTSKKMSTLAHPPNILEMSQEIKKNCGGKQVEITLERTKMTKGIKEKQSNDLEKAAF 82  human
Q8C636         5 KSRSLETTVKRVYRDLLL--PKINTSKKMSTLTNSPSSLEGTPGIKKNSGEMQAEASAERVKLTKSIKEKQNNELEKVAL 82  house mouse
XP_003766074   2 dSRSLENAGNRTCHDQMV--PKMNVSKKIVMLASPLHALDMPQEVKKSCPEKQGEMGNERVKMTKALKEKQSGELDRAGL 79 
XP_006001056   5 KSESSKNSSSENLQDKAVlkPDLSDANRNIFVESVTDNSETTLGIRINPGKKSKGKLRQKVTNTRNVKLKRASLLDSSGV 84 
XP_008703548   5 SSRNLENTVNRVYPDQLI--PKINTSKKMSTLANQPSILEMSQEVKKSCGDKQVEITVERIKMAKSIKEKQSNDLEKVAF 82  polar bear
Q9BXB7        83 KRKAEGEEKPTR-KKQAKITELDNQLI-TMPLPHIPLKNIMDVEMKLVYIDEMGVRYEFVESFMSTGSQPTCQAAEIVDP 160 human
Q8C636        83 KRKADSEEKLVG-KKEAKIMELDNQLVtTVPLPHIPLKNIMDVEMKLVYVDEEDVSYEFAQPNMCLGLQATGQTATTMPP 161 house mouse
XP_003766074  80 KRRTESEEKPPAlKREPRATELESQLI-AVPLPHIPLKNIMDVEMKLVYIDEEDVTYEFVEALVSTAAPAPCPAADIADS 158
XP_006001056  85 KRKSEIEEKSIA-KKEQRTFGLEDQSQ-NITLPRILLKSVMDVEIKLVYIDEQDITYEFMESQSSTSAQSMCQVVEVGDS 162
XP_008703548  83 KRKAENEEKPAG-KKEAKITELDSTLI-TMPLPHIPLKNIMDVEVKLVYIDEEDVSYEFVESFMSTGIRPTCRAAETVDP 160 polar bear
Q9BXB7       161 LSVHNFSFLPQIDKWLQVALKDASSCYRQKKYALAAGQFRTALELCSKGAVLGEPFDAPAEDIASVASFIETKLVTCYLR 240 human
Q8C636       162 ASPRDLTTLPQIDKWLQVALKDASSCYRQKKYAVAAGQFRTALELCSKGAALGKPFEAHAEDIASIASFIETKLVTCYLR 241 house mouse
XP_003766074 159 LNAPHLAFLPQIDKWLQVALKDASTCYRQKKYAMAAGQFRTALELCSKGAALGKPFEASAEDISSVASFIETKLVTCYLR 238
XP_006001056 163 LSAPNLSLSPQIDKWCEVALREASSYYRQKKYAVAAGRFRTALELCNKGAVLCEPFTASHGNISCVASFVETKLVACYLR 242
XP_008703548 161 LHVPNFNFLPQIDKWLQVALKDASSCYRQKKYAVAAGQFRTALELCSKGAALGKPFEASAEDIASVASFIETKLVTCYLR 240 polar bear
Q9BXB7       241 MRKPDLALNHAHRSIVLNPAYFRNHLRQATVFRCLERYSEAARSAMIADYMFWLGGGREESISKLIKLYWQAMIEEAITR 320 human
Q8C636       242 MRKPDLALNHAHRSIVLNPAYFRNHLRQAAVFRCLERYSEAARSAMIADYMFWLCGGSEHSVSKLIKLYWQAMIEEAITR 321 house mouse
XP_003766074 239 MRKPDLALNHAHRSIVLNPAYFRNHLRQATVFRCLERYSEAARSAMIADYMYWLSGGSEQYVSKLIKLYWQAMIEEALTR 318
XP_006001056 243 MRRPDLALNHSHRSIILNPVNFRNHLRQAAVFKALERYVEAARSAMIADYMYWLSGGREQHMSKLIKLYWQAMLEEAITR 322
XP_008703548 241 MRKPDLALNHAHRSIVLNPAYFRNHLRQATVFRCLERYSEAARSAMIADYMFWLCGGSEQCISKLIKLYWQAMIEEAITR 320 polar bear
Q9BXB7       321 AESFSVMYTPFATKIRADKIEKVKDAFTKTHPAYAEYMYTDLQALHMLPQTVDWSSFPPQQYLLTLGFKNKDDGKFLEKI 400 human
Q8C636       322 AEAFSVMYTPFATRIKPENIEKVKEVFMRTHPTYVDCIYTDTQGLHVLPQTADWSCFPPQQYLLTLGFKNKEDGKFLEKV 401 house mouse
XP_003766074 319 AESFSVMYTPFATKVRPDKIEKVKEVFTKTHPAYVEYMYTDLQGLHVLPQTVDWSSFPPQQYLLTLGFKNKEDGKFLEKM 398
XP_006001056 323 AESFSVMYTPFAAKPRVDRKEKVKEVFKQKHSAHAEYIYTDPEVIHVLPQTADWSSVSPQHYMLTLGFKNKEDGFFLEKI 402
XP_008703548 321 AESFSVMYTPFATKIRADKIEKVREVFTKTHPAYVEYIYTDLQGLHILPQTVDWSSFPPQQYLLTLGFKNKEDGKFLEKL 400 polar bear
Q9BXB7       401 SSRKLPIFTEHKTPFG-LTREDTVRQMETMGKRILPILDFIRSTQLNGSFPASSGVMEKLQYASLLSQLQRVKEQSQVIN 479 human
Q8C636       402 SSRKLPTYTEHKTPFSpLTREDTVRHMETVGKRILPILDFIRSTQLNGNFHACSGVMEKLHYASLLSRLQRVKEQAQVIN 481 house mouse
XP_003766074 399 SSRKLPTFTEHKTPFSpLTREDAARHMETMGKRILPILDVIRSTKLNGSFRACSGVIEKLQYASLLNRLQRVKEQSQVIN 478
XP_006001056 403 FRRKLPTFTEKKTFFGpVTVEEAAKNLETFGKRILPVLEFIKSTKLAGGFCAGSGVIEKLQYVSYLSLLQRVKEQSQVIN 482
XP_008703548 401 SSRKLPTFTEHKTPFGlLTKEDTVRHMETMGKRILPILDFIRSTQLNGSFHGCSGVMEKLQYASLLSRLQRVKEQSQVIN 480 polar bear
Q9BXB7       480 QAMAELATIPYLQDISQQEAELLQSLMADAMDTLEGRRNNNERVWNMIQKVGQIEDFLYQLEDSFLKTKKLRTARRQKTK 559 human
Q8C636       482 QAMAELATVPYLQDISQQEAELLQSLMADAMDTLEGKKSDKERVWNTIQKVGRIEDFLYQLEDSFLKTKKLRTARRQKTK 561 house mouse
XP_003766074 479 QAMADLATIPYLQDISQQDAELLQSLMSDAMDTLEGRRNDKERVWNKIQKVGLIEDFLYQLEDSFLKTKKLRTARRQKMK 558
XP_006001056 483 QVAAELATIPYLQDINQQDAELLQLLMADAMDTLEVKRSDRERVWNKIEKVGLIEDFIYQLEDNFLKTKELRNARKQRMK 562
XP_008703548 481 QAMAELATIPYLQDISQQEAELLQSLMADAMDTLEGRRNDKERVWNRIQKVGRIEDFLYQLEDSFLKTKKLRTARRQKTK 560 polar bear
Q9BXB7       560 MKRLQTVQ 567 human
Q8C636       562 MKRLQTVQ 569 house mouse
XP_003766074 559 MKRLQSVQ 566
XP_006001056 563 MKRPQSAK 570
XP_008703548 561 LKRLQTVq 568 polar bear
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