Conserved Protein Domain Family
GT29_ST6GALNAC1
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cd23973: GT29_ST6GALNAC1 
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).
Links
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Statistics
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PSSM-Id: 467701
Aligned: 6 rows
Threshold Bit Score: 556.672
Created: 27-Nov-2018
Updated: 27-Apr-2023
Structure
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Aligned Rows:
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putative activeputative
Feature 1:putative active site [active site]
Evidence:
  • Comment:based on homology to other members of the family
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
Q9NSC7    279 CPDSVKIKAskslwlqkLFLPNLTLFLDSrhfnqsEWDRLEHFAPPFGFMelNYSLVQKVVTRFPpvpqqqlllaslpag 358  human
Q92183    254 CSESVRAKAaksdwlrdLFLPNITLFIDKsyfnvsEWDRLEHFAPPYGFMelNYSLVEEVMSRLPpnphqqlllansssn 333  chicken
OCT60715  202 CPTSVKSKAlnapwlslIFLPKIILFMDNrhfskqIWDRLQYFTPPYGWMalDYTVVKEVVSSLPtlldqqilytamrpg 281  African clawed frog
RXM98109  148 CPESIRSRSaeidwfkqLFIPDISLFMHKehfndeEWKRLEHFNPPYGWMgtNYTEVKQAVELIPglkeqkvl--lspkr 225  sterlet
PWA21468  119 CPQSLRYSKdkd--fqkAFLPNIRRFLHKdnfsirEWNRLSHFNNPFGFMgmKYGDVMPVMKLIPkpkepll---lpkpg 193  western mosquitofish
Q5P991    118 CATSLQNSSnpt--fkkKFIPNIQLFLQSdhlnmsEWNRLYHFNNPFGYMglNYTAIKAAVETIHkpassqll-qvhpgv 194  zebrafish

Feature 1               ###                    ##                    #                        
Q9NSC7    359 slRCITCAVVGNGGILNNShmGQEIDShDYVFRLSgALIKGyeqDVGtRTSFYGFTAfsltqsllilgnrgfknvplgkd 438  human
Q92183    334 vsTCISCAVVGNGGILNNSgmGQEIDShDYVFRVSgAVIKGyekDVGtKTSFYGFTAyslvsslqnlghkgfkkipqgkh 413  chicken
OCT60715  282 ghQCISCAVVGNGGILNGSgvGQEIDShDYVFRVNgAIIKGfenDVGtRTSFYGFSAftmlssltnlnkrgfsklpqhne 361  African clawed frog
RXM98109  226 ndGCIRCAAVGNGGILNGSrkGAEIDShDYIFRVNgAVIKGfedDVGvRTSFYVHTAqtmlsslwgyqelgftnvpmdke 305  sterlet
PWA21468  194 gdGCVRCAVVGSGGILNGSkmGAEIDAhDYVFRMNgAVINGyeeDVGkKTSVYVHTAhsittsrkifqeygyksaphdqg 273  western mosquitofish
Q5P991    195 kdGCIRCAVVGASGILNGSklGKEIDSsDYVFRMNaAIIAGheeDVGkRTSVYVHTAhsiiqslmihkkrgfkqiptdkd 274  zebrafish

Feature 1                                                                                     
Q9NSC7    439 VRYLHFLEGTRDYEwleallmnqtvmsknlfwfrhrpqeafrealhmDRYLLLHPDFLRYMKNRFlrsktldgahwriyR 518  human
Q92183    414 IRYIHFLEAVRDYEwlkallldkdirkgflnyygrrprerfdedftmNKYLVAHPDFLRYLKNRFlksknlqkpywrlyR 493  chicken
OCT60715  362 TRYILFAEARRDYAwldalqknktindgilesyrqyprsdfgdsfdpKKLLVAHPDFMRYLKNRFargntlktkywmiyR 441  African clawed frog
RXM98109  306 IKYIMVTEGMRDYQwlralllnttvsrgpy--lkmrprsyfgtdftpEKYLVAHPDFNRYIKNRFlksktvegidwaiyR 383  sterlet
PWA21468  274 IKYVLIPEGLRDFQwlqsllkgenvpsgey--tgedprsyysgqfseDRFYVLHQDFLRYVRNRFlsssdlsgeywavvR 351  western mosquitofish
Q5P991    275 IKYVLIPEGPRDYNfleslmknrkipsgay--rgrtprkyysghfneSSYYILHPDFLRYVRNRFlrakqlktkrwwvvR 352  zebrafish

Feature 1      ###                 ##        ###              #                       
Q9NSC7    519 PTTGALLLLTALQlCDQVSAYGFitegherFSDHYYDTSwkrlifyinHDFKLEREVWKRLHDEGiiRLYQR 590  human
Q92183    494 PTTGALLLLTALHlCDRVSAYGYiteghqkYSDHYYDKEwkrlvfyvnHDFNLEKQVWKRLHDENimKLYQR 565  chicken
OCT60715  442 PSTGALLLLTALHlCDTVSAYGFmtedyldYSDHYYDLKktpikfyanHDFRLEKDLWNRLHKLNiiKLYQR 513  African clawed frog
RXM98109  384 PTTGAFALLLALHlCDVVDAYGYitedyakYPNHYYDKTktktvfyvnHDFGLEIKEWKKLHDAKimNLYHG 455  sterlet
PWA21468  352 PTNGAFTLFMALHtCDTVSAYGFmtedyskYPNYYVDKHlteivfyinHDLILEKNLWKSLHDKKilKLYQR 423  western mosquitofish
Q5P991    353 PTNGAFTLLLAMHtCDIVRVYGFctadyrkYPSYYYDTKhtklvfygnHDYRLEMKTWKKFHDDKliWMYLG 424  zebrafish

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