Conserved Protein Domain Family
DUF4537

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pfam15057: DUF4537 
Domain of unknown function (DUF4537)
The function of this domain family is unknown. It is found in eukaryotes, and is typically between 119 and 141 amino acids in length. In humans, it is found in the chromosomal position C11orf16.
Statistics
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PSSM-Id: 464475
Aligned: 19 rows
Threshold Bit Score: 115.869
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q58DB9         85 DTWVLARREPDGFYYRAQIKAAPeleRQGVLLVEFeaplatgpelPAQRQSVVLEEDVIQFS-PTM-EFSLRPGDKVLAP 162  cattle
EEN62311     1868 GARVMALLVSDKHWYPGVILKTL---KNDRYLVRF----------EDEDETTVRPREIAARN-MMV-VARLPVNTAVLAS 1932
EFB24068      430 GQKVIARCDENGFYFPGVVKKCV---NPTHALVGF----------RYGDTKVVPTSFITPIG-GAMpCPLLQVGDYVFAK 495 
XP_002611587 1119 GHKVIARKEEDGFYYPGIVVKCP---NSRHAIVDY----------HGNGRQLTPTRFVIPMG-GARaCPELRVGDFVLVK 1184
EDO28327      530 HHKVLARNEVDGFYYPGLVSKCI---NSRYVEVDF----------NDCERQAVSVRYVIPVE-GARpCPTLKVGDYVLVR 595 
EDV24931     1007 GQRVVARSSSDGFYYAGTVIQSS---SIRRAEIEF----------DNLDIQVIPTRFIISVG-GAQpNPFLQISDYVLVR 1072
XP_004998525 2399 GMRVVCRYDEDNLYYEGTVLSRLs-rSGRWFKISLd---------DGHVVRAQEPRHMLAHSrDGEgEHVLRAGDHAIAL 2468
EDO38960      314 GQAVVARNDKDGTFNLGTVRERVg--NGRQYIIEW-----------ADQTVQLQSSGYMFGA-HTK-RHPLAIGDRVLAL 378 
EEN43659      296 GTRVLARRDEDGYYYMGTVANQLp-dAKGRFMIEFdkv-----ptLKSRMQETGIYDMIAHV-DAF-RHKIVPGDKVLAP 367 
XP_019645026   22 GHAVVARDDSDGAYHLGTVKERVg--NGRQYVVQW-----------ADESLQVQSSSCIFGA-FTK-RHALALGDRVLAV 86   Belcher's lan...
Q58DB9        163 ------WGPDQQR----------YGPGTVLLGLEagdlqRASRKEEEITVHFWNGR-TAP--VPLRGVQWV-PP-AVWKK 221  cattle
EEN62311     1933 v-----EDVQDCV----------YAPGIIRGYHH-----NGETGEEEYLVEFNDGS-TVR--APHANVILNpEQaAAYRA 1989
EFB24068      496 i-----VIPNGFDf---------YVPAIVIALPN-----QDVADDKFYTVLKCNNR-REF--CPRSALIKI-SQ-NKYAL 551 
XP_002611587 1185 t-----TSEEDLEc---------WVPGIVQMTPR-----RREAQLKFYTILQFDKK-RVT--SLRKGIMKI-PK-SRYVF 1240
EDO28327      596 t-----PVPREVEddviadgaccYVPGIVQVVPL-----RKSPATRCYTILRFNGK-KIGtnIPSCLCRKL-DE------ 657 
EDV24931     1073 t-----LAPDQQRy--------rYIPGIVQSIPNk----ELPNEMRYYAVVAYNGR-KLA--GPRNALIKI-AK-SRYAF 1130
XP_004998525 2469 hyhgepGDPYEHSi---------FGPAKVL-----------ASTLHAITVRFWDGK-KCQ--LRRSQCYFV-SK-QYYQA 2523
EDO38960      379 ------ADAASYV----------YIPGWVT-----------GSNGRRLVVKFCNGKsSSH--VDPLQCFWL-SR-DYYDG 427 
EEN43659      368 ------WEVTGQR----------FGPGTVLEGVErr-feDSIDDDEDLVVTFWNGK-TES--VPRHKAIWI-PL-MLYER 425 
XP_019645026   87 ------ADPVALV----------YLPGWIT-----------GTNGQKLVVKFCNGTtSAH--INPRQCFWL-SQ-EYFDI 135  Belcher's lan...
Q58DB9        222 AVDGL 226  cattle
EEN62311     1990 QVMRV 1994
EFB24068      552 SCSHI 556 
XP_002611587 1241 ACRYI 1245
EDO28327      658 -LVYF 661 
EDV24931     1131 TCRYI 1135
XP_004998525 2524 ACEAL 2528
EDO38960      428 VVDFF 432 
EEN43659      426 VIFEL 430 
XP_019645026  136 AVNFW 140  Belcher's lancelet
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