Conserved Protein Domain Family
RNA_polI_A34

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pfam08208: RNA_polI_A34 
DNA-directed RNA polymerase I subunit RPA34.5
This is a family of proteins conserved from yeasts to human. Subunit A34.5 of RNA polymerase I is a non-essential subunit which is thought to help Pol I overcome topological constraints imposed on ribosomal DNA during the process of transcription.
Statistics
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PSSM-Id: 462395
Aligned: 73 rows
Threshold Bit Score: 37.3556
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007326994  71 DEDVEVWVIRVPESIKPKHLEglSFDLDEptsspsrRKKRTTAligslKRKHNSYDIWSLGddhdedqgektteptslIG 150
EDO48101     107 NKKKEIWLIKVPFNFDRRSLSgeTFVLNG--------SQDLLVt----QANTKKYEISSRAlks------------hdQS 162
EDK37676      44 RDNREIWLIKTPKGFPIEKLQ--TLPVSFgltskngLNTSAATf----KVENRSFQLYEESfaa------------esEA 105
XP_011273772  27 LDKKEIWLIKTPKGFKFDGLT--KIPINF-------NPNGTSLd---fSKDSKNYNIQEDLtnfnsnl---sgksedvSS 91 
Q6BWD0        42 QNDKEIWLIKTPKGFPLKNLK--TLPVSFta---tsISNGPSRf----NLNQKNFQVNEELlgt------------dtES 100 Debaryomyces ha...
CCE81586      81 PKNKEIWLIKAPKGFQLNKLK--KIPVSFts---tsINNGPDSf----ELDDRKFQVNEEIlsa------------etDN 139
XP_001527936  49 DNDKEVWLIKTPKGFPIHKLK--SLPISFk------kSKKAEAf----EVNDHLFEISEEVtagkqa-----asgdddED 111
CCE41956      44 AKDKEIWLIKTPKDFPLEKLK--TLPIAFt------kNRVAEPf----DIVGSTYQVEEELsstsast----iipsteIN 107
Q5AP67        45 LKGKEVWLIKTPKGFPLTDLK--KLPISF-------SGKSAESf----KVNNLSYQVTEDLgas-----------asdTN 100 Candida albicans
XP_002549014  51 LKGKEVWLIKAPKGFPLKDLK--TLSVAK-------KNKGNESi----KVNKISYKIDEDFdi-------------dnDS 104
XP_007326994 151 GDELkslscLLPRNTKnGKLYAapkPIARHILVSAQPAQPTTTSTDSdsptemVYTNPPRENyPPElLTHRFMPYGSLVK 230
EDO48101     163 SCKV-----LLPSTENkSVWSAr--PVNGHMTVIQSRHVPIADi--------aPCPPPTKHK-VPD-IRCRWKPFGSGDp 225
EDK37676     106 HKYS-----ILGHKGEnQLEPVe-kTIDRFYNISEKIAIPDINYEKV------VIPRKDVEK-IDG-LVMKHYPTGYGAs 171
XP_011273772  92 KYSL-----LIPKETKnGLKIQnslKINKFYNIKESVSIPDINYGKV------IKKRKNIRT-IKG-LKPQHFATGYD-R 157
Q6BWD0       101 SKYA-----VLTNENKkNFKIVg-qDISRFYNIRESVDIPSIAMDEV------VKPRKNIKE-IKN-LRMRHFPTGYGAe 166 Debaryomyces ha...
CCE81586     140 KKYS-----VFLSEKDgKYLASe-kNFSRFYNIREVVDIPKIDYGKV------VKPRSDVKK-IKN-LRMRHFPSGYGSA 205
XP_001527936 112 KKHT-----IFKAGKSdTFRPTs-yKISRFYNIRETVKIPEINFEEA------VVPRKDVPQ-IEG-LRMRHFPTGYGQK 177
CCE41956     108 NKHT-----IF-KAKHdSFRPTd-lKISRFYNIKEVVNIPQIDFDKS------RIPREDVPQ-LKR-LRMRHFPTGYGEK 172
Q5AP67       101 NKHT------IFSSKKrSFRPLg-eKISRFYSIHEVVDIPEIQLDKV------VVPRQNVPK-IKK-LRMRHFPTGYGAD 165 Candida albicans
XP_002549014 105 NNKH-----TLFASKKaGFKPId-aKISRFYSIHEVVKIPSIDLDKV------VVPRENVQK-VKK-LRMRHFPTGYGAK 170
XP_007326994 231 TSTDsdndedendtavtsrmdnevvmtevdsnvqsDVAKKEERAIKSSSSKKKDkkvee-eedieVEEERQKEKKEKKKS 309
EDO48101     226 ddsadrl--------------------qenhvptpPLAYTPVRSLKEEQNLRESlqasveeslesHEQEKKAKKKNKQPK 285
EDK37676     172 dfe----------------------------earaPKRTASHSENGTHKKRKTE-----------SESGEKEKKEKKDKK 212
XP_011273772 158 VEEDvasd------------------------aedVEIKDEEKDQDGDLKIDDDe---------aKVEAKKEKKDKKEKK 204
Q6BWD0       167 dfde--------------------------akpqgGDVNASDTDSEDDGKIVKK-----------AKIEEKSKSDKKDKK 209 Debaryomyces ha...
CCE81586     206 DYEE-------------------------------ADGKDLSDLDDNSDKEQVS-----------EKKEKNEKKDKKEKK 243
XP_001527936 178 DYGLmaesgkrkknedd------ekeekeeeeeedRSRDIEEGKILKRAKVDKD-----------EGSPRKDKKERKEKK 240
CCE41956     173 DFKVtyddd----------------------dsdvEEGKAVKRTRKEEPAFDEP-----------HKEKHSSSKHQKENK 219
Q5AP67       166 DYQFdkeeeeeee--------------eesenddvEAGKVLKKAKV-------------------EEKEEKEAKHKKDKK 212 Candida albicans
XP_002549014 171 DYQIdgaqee-------------------esededVSSGKVLKKARVESKPQAD-----------DEEDIKEKKTKKDKK 220
XP_007326994 310 GRK---------------RKGEEG---VSPKKSKKS 327
EDO48101     286 IKHepespkqnsmsmsitTPVNLKqecPTDYQSSKK 321
EDK37676     213 EKKek-----------keKKEKKEkkdKKDKKEKKE 237
XP_011273772 205 EKKe--------------KKEKKEkkdKKDKKIKKE 226
Q6BWD0       210 EKKe--------------KKEKKEkkeKKSKKEKKD 231 Debaryomyces hansenii
CCE81586     244 DKKd--------------KKDKKEkkeKKEKKEKKE 265
XP_001527936 241 EKKe--------------KKEKKD---KKDKKEKEK 259
CCE41956     220 DKKe--------------KKEKKEkkeKKEKKEKRE 241
Q5AP67       213 EKKd--------------KKDKKDkkdKKDKKDKKK 234 Candida albicans
XP_002549014 221 EKKd--------------KKDKKDkkdKKDKKEKKK 242
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