Conserved Protein Domain Family
Myoregulin
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cd20260: Myoregulin 
Myoregulin
Myoregulin (MLN) is encoded by a skeletal muscle-specific RNA Linc-RAM, which is annotated as a putative long noncoding RNA (lncRNA). It is a single-pass transmembrane alpha-helix that interacts directly with sarcoplasmic reticulum (SR) calcium transporting ATPase (SERCA) and impedes Ca(2+) uptake into the SR. SERCA is the membrane pump that controls muscle relaxation by regulating Ca(2+) uptake into the SR. MLN is the dominant regulator of SERCA1 activity in adult skeletal muscle and is a promising drug target for improving muscle performance.
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Statistics
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PSSM-Id: 380769
Aligned: 28 rows
Threshold Bit Score: 51.2554
Created: 31-Jul-2019
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P0DMT0         2 TGKNWILISTTTPkslEDEIVGRLLKILFVIFVDLISIIYVVITS 46  human
NP_001291736   2 TGKNWILISTTIPkslEDEIVGRLLKILFVIFVDLISIIYVVITS 46  chimpanzee
NP_001291756   2 TGKNWILISTTPPkslEDEIVGRLLKILFVIFVDLMSIIYVVITS 46  Rhesus monkey
XP_012374196   2 TCKNWVLISTSTPkslEDEIVGRLLKILFVIFVDLMSIMYVVITS 46  nine-banded armadillo
XP_012781945   2 TGKNWILISTSTPknlEDEFVGQLLKILFVIFVDLMSIMYVVITS 46  American pika
XP_012969364  67 SGKNWILISTTSPqslEDEILGRLLKILFVLFIDLLSIVYVIITS 111 golden hamster
XP_012789958   2 TCKNWILISTTAPtslEDEIVGRLLKILFVIFVDLMTIMYVVITS 46  European shrew
XP_017532193   2 MCKNWILISTSTPaslEDEIMGRLLKILFVIFVDLISVMCVVITS 46  Malayan pangolin
XP_017657592   2 SAKNWVLIPTTTSqslEDEVLGRLLKILFVLFVDLMSIMYVVITS 46  Upper Galilee mountains blind mole rat
XP_016041158   1 MSRNWILISSTNPtsmEDEIMGRLLKILFVIFVDLMSIMYVVITS 45  western European hedgehog
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