Conserved Protein Domain Family
MFS_MJ1317_like

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cd17370: MFS_MJ1317_like 
MJ1317 and similar transporters of the Major Facilitator Superfamily
This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Statistics
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PSSM-Id: 340928
Aligned: 80 rows
Threshold Bit Score: 179.276
Created: 1-Nov-2016
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative chemical substrate binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of MFS transporters with bound substrates, substrate analogs, and/or inhibitors
  • Comment:since MFS proteins facilitate the transport of many different substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides, the residues involved in substrate binding may not be strictly conserved among superfamily members
  • Comment:the substrate binding site or translocation pore has access to both sides of the membrane in an alternating fashion through a conformational change of the MFS transporter

cd17370 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd17370 is a member of the superfamily cl28910
cd17370 Sequence Cluster
Sub-family Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               ##  ##  #                                #                            
Q58713     24 VYLLGFTSFLNDMSSEMIMPILPMLIt-sVGGGSLSIGLVGGLREFISNILMVLIGYCSDKvrKRKIFVVLGYLTSSMFK 102 Methanocaldococcus...
ODU24115   22 VLGIGLASLFSDWSHEIATTVMPAFLa-tMGAAAAWLGLIEGVSDGLSSFAKMASGYYTDRlrRRKPIAVAGYVVTTLGT 100 Verrucomicrobia ba...
OLZ11777   36 VWGFSLASLFSDMGHELVTTVLPAFLl-tIGAPVFALAVIEGVSNFSQSLSSLLGGKWANNtgSRRSIVVIGYILTGIKA 114 Sulfobacillus ther...
EGD06333   24 VAGAGVTSALGDFCYETTTVILPGFLa-vLGVPAAALGVIEGMADAVASFTKMASGYIADKlgHRKRLVLAGYALTPIGQ 102 Burkholderia sp. T...
CUQ68160   11 VVGIVLATFLSDFSHEMCTAVLPLYLa-tVGLGPAALGVIEGVADFLVSLSKLAGGVVGHHveHKRPWTTVGYLVTTLAT 89  Nitrospira sp. ENR4
KBZ63042   25 VGAVGVASFFSDSGHEITTSVLPAFItgtLGASASALGIIDGISDALIGVMKLVGASPANDrtKRGRTASGGYLGTALAT 104 Mycobacterium tube...
ACU53011   12 VWLISLSAGFADLGYQAIVAGVPLLIvvdLRASALVYGVAAGLGYGLGTFASLAGGRLADR--IGRRPVAIGGNLGILLL 89  Acidimicrobium fer...
Q973W8      9 VLKISFSAFFADLGYQAAVASFPIIFvfyFHAPIFLYGIAEALNYGGGSLMSILGGYLADKy-GRKMIAVIGNALIVILS 87  Sulfolobus tokodaii
KUO91238    8 VLKISFSAFFADLGYQAAVVMFPLIFvfyLGAPMWLYGVAEAINYGLGSLMAFLGGLAGDRf-GRRRMAVLGNAIIISVS 86  Caldivirga sp. JCHS_4
KJE49024    7 AYFVGLSAMFADMGYQGAMALLPVYLvfvLKLNFIYFGIAEALIFGFGSLFSYLGGKLSDRy-GSKNVAVAGNSLIPFLS 85  Acidiplasma sp. MBA-1
Feature 1                           ## ###  #                   #  ##  #                      
Q58713    103 LLLGLSKSWlgAVIFSSLERMGKGIRTAPRDAIISesm-pktLGKGFGIQRAFDTAGAILGSTLSLLFIlyl-------- 173 Methanocaldococcus...
ODU24115  101 AAFGLATSAwhVLLARAFAWFGRGVRTPVRKALLAgsvtkqtYGRAFGFERMMDTLGAIVGPASAFFLLqav-------- 172 Verrucomicrobia ba...
OLZ11777  115 LIALVSYWPw-IVLLRTLAWIGRGARGPIRDTMIAdevppsdRGKAYGFRETFDTLGAILGPLAATLLIam--------- 184 Sulfobacillus ther...
EGD06333  103 IFIALAAGWqlLLLGRLVSWFGKGLRGPLRDAIVIqavsaetRGRAFGFHRAMDTIGAVLGPLLGVVVLewaqavhhgdl 182 Burkholderia sp. T...
CUQ68160   90 GAIGLVGGLasLVSLRSLAWIGRGFRGPLRDSMLAdavnpsyFGRAYGLERAGDMLGAVAGPLVATLLVwg--------- 160 Nitrospira sp. ENR4
KBZ63042  105 GAIGAATAVwqAGLFRALAWLSRGLRSPSRDALLAslspksaHGRAFGLERAGDNLGAVAGPLLAAGLVaw--------- 175 Mycobacterium tube...
ACU53011   90 SLIALARSVpiVVLLFVLGWLARNFRSPVRRAMLTeavapewRRNAFGLLHAVDVGGGVLSALAAVVLVgah-------- 161 Acidimicrobium fer...
Q973W8     88 FTGLAVNYIe-ALFLFMFGWWFRNFRTPARRAMLSevteeseRKEAYGILHALDIAGATLAVAYLTIALyf--------- 157 Sulfolobus tokodaii
KUO91238   87 LLGFARYWWq-ALLIFMVGWWFRNFRTPPRRAMMTevtdpgeRNEAFGILHALDIAGAALSITYTAILLfv--------- 156 Caldivirga sp. JCHS_4
KJE49024   86 FTGFTYIPLi-SVGLFSTGWWMRNLRSPARRAFLAenteeneRTSSFGILHSLDVGGGIISILILVILIll--------- 155 Acidiplasma sp. MBA-1
Feature 1                                                                   #  ##  ###  #     
Q58713    174 qySFNQIILIAAVIGFLTLIPLYFvkekpspsnn--------kitfrvgiknLPKELKLFILISAIFTLSNFSYMFYILR 245 Methanocaldococcus...
ODU24115  173 nhHYPTLFAFTLIPGLIATGLIAFvvkekdrkpvp-------hisfgeslraLPMRFRKFLIAVGLFGAGDFAHTMLILL 245 Verrucomicrobia ba...
OLZ11777  185 -iSSRTLIALSAIPAVLTILVIGLfirepkrvqftketplessgskpgeaisWPEQYRIFRRAVIVFWFSQAAPTFFILR 263 Sulfobacillus ther...
EGD06333  183 agPFRLVLWLSIVPGALAVLVFLAmvddpeqspnp-------grrfwgtlraLPARFKQYLGAVGLFGLGDFSHSLLILA 255 Burkholderia sp. T...
CUQ68160  161 giEFRTVILWTLAPGLLAAAAIFFlaqerpapqvsq----sdavrprpgwraFPRSFWLFLAGVFLFGLGDFSRTFLVLL 236 Nitrospira sp. ENR4
KBZ63042  176 -lGVRPALFLAAIPGLFAALAILVaarearrggqtss---epvarrlqlgalRDAGMLRALLPVALFEFGNLAATLLILR 251 Mycobacterium tube...
ACU53011  162 vvGLRGLFAFTAIPIAISSLLLASahphrtggag---------arrdvptapASTLRRAVLVATALYGFSSYALGFPVLA 232 Acidimicrobium fer...
Q973W8    158 gvKATEILIFTSIPLIISTLFLVFvkaggk-----------------gipkkPGKVALTIVISTMFFAFTQYSFGFPIIT 220 Sulfolobus tokodaii
KUO91238  157 kfPVEYLLLITAAPLVVSTLLIALvnaghranag---------sasfmelrgLGRALWLIVVSTFFFGFSQYSFGFPVIT 227 Caldivirga sp. JCHS_4
KJE49024  156 nfTYKYLFLFSIFPIIISTLILASiksnkhlplk--------ksnkktvlenNKYIFYGIIIATSLFGFGSYSMGFPIIT 227 Acidiplasma sp. MBA-1
Feature 1                                  #   #                                              
Q58713    246 aqeflmiv--dekmaiiiPIALYILYNIFYATFSIPFGILSDkiGRKSVLTIGYIVYGIVSLGFayfi-----sqksLIL 318 Methanocaldococcus...
ODU24115  246 atqkltpal-gatkaasiAVGLYVLHNVLYATFSMIAGWLADrfNKGGLLAAGYVLAALMALAIillpm----nlwtLAL 320 Verrucomicrobia ba...
OLZ11777  264 vllahphg--lpfstdvlGFALYTIHNIFYAASSYPAGLMADhgHPKLATVTGYVLWTLSLLGFadfhl---lpllfWPV 338 Sulfobacillus ther...
EGD06333  256 atqlltpsf-gvvraaqiAGLLYVGRNVVQVLASYPVGVWADriGALRLLVGGYLIGAATAALIaalwwlgvasvplLGV 334 Burkholderia sp. T...
CUQ68160  237 gaqqfgetslhaegalsaAILLYTAHNLISALAAYPIGSRADrgSKLSILLWGYGLGVGTNLLLawaga----svggLLI 312 Nitrospira sp. ENR4
KBZ63042  252 aahlfasptrsltaatslAILVYACHNIAATVASLLAGRWYDraGPRAVFVTAAGVYVVGYGLFavggt----gvalVVV 327 Mycobacterium tube...
ACU53011  233 vaars--------gsateGFGAYALFLGASAITGYVIGARRGs-PIGWLALGGYGLSALGSALLvpes------amvSII 297 Acidimicrobium fer...
Q973W8    221 teeft--------rrfylATLTYGVFLASSSIFGYVFGKIKLe-EVKGLAFLGYLLAGLTSFGFaflsp---lgvisIYP 288 Sulfolobus tokodaii
KUO91238  228 taeft--------hedylAVVTYGVFLAASAVFGYVFGKSRVn-EYTGLSYLGYLLGVFASLGFallsp---mgvtgIYP 295 Caldivirga sp. JCHS_4
KJE49024  228 vaqnadys---qslkiisGIVSYGIFLGFSSLTGYILSRVNIksQISSLAIFGYILSGAGTLGIvitliy-glglpgFYI 303 Acidiplasma sp. MBA-1
Feature 1            ##   #   #               #  ##  ##  #                                   
Q58713    319 LFALYGIAYALFAGNQKAYVSDlssediRATALGLFYTVVGLTSLPASLIAGYLWk-iSPEMTFLYGSVLAIISGLLLL 396 Methanocaldococcus ...
ODU24115  321 IFIVGGVYVAMEETLEDSFCAElveeehHGMAFGTLATVNGVGDFVSSLVVGFLWtafGTQVAFVYSAALFILGGSLVL 399 Verrucomicrobia bac...
OLZ11777  339 LFIFSGLATGLIETGQKTLTVAilsphvRGMGLGQIAGLKGLSQLVGTLVIGALWtlhQPAWGFLVLSVAAVLGIVNMT 417 Sulfobacillus therm...
EGD06333  335 VFLLAGCYVAVQETLESTVTADmvssdtLAISYGALGSVNGCTKFLSSGMVGALWtgvSPMVGFGAAAALMFAGVVALR 413 Burkholderia sp. TJI49
CUQ68160  313 AVACSGVYIAVEETLEKAVVAErlprelRSLGLGLLACANAVGDMVSSLYVGYLLdhhQAEAAFGIAAFCGAIGVLWLM 391 Nitrospira sp. ENR4
KBZ63042  328 AFCAAGVGIGLAEPIESAVVSQllpdrlRGSGFGVLGAVQAAGDLVATVVAGFLYtlvSPAAAFGYAAAWMAAAMLAAG 406 Mycobacterium tuber...
ACU53011  298 GVGLLGVGLGVIETLEPTVISRlapdaaQGGALGALSAARSVGLFVADVVAGLLYa-sHGGVAFVYGAVLAAVAAIIIG 375 Acidimicrobium ferr...
Q973W8    289 LSVIMGIAVASTETFEPTIISKlsr-geTGTAMGALSFGRSIGVLIGNTIMGFLYq-ySYSYSYIFAGIMGIIAFLIVF 365 Sulfolobus tokodaii
KUO91238  296 SAFLLGVAVAATETFEPTIVSKlapeerMGMGMGLLSFGRSIGIFLANTIMGLLYq-lHYSYAYYFAAASSFTAFLIVR 373 Caldivirga sp. JCHS_4
KJE49024  304 SIIIASVAFGIVETYEPSIISKsvdaskLGAGMGILSSSRSVGYFIANLIMGFLYe-iSPEFSYAYAGIVSIAAGIIIL 381 Acidiplasma sp. MBA-1

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