Conserved Protein Domain Family
DUF5580

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pfam17743: DUF5580 
Family of unknown function (DUF5580)
This is a family of unknown function found in metazoa.
Statistics
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PSSM-Id: 465478
Aligned: 11 rows
Threshold Bit Score: 724.276
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006096178   1 MSSVRKTPRASDAMPETVVKIIGSKHFRYLVEKPKIKEEENLKAETQRVFQKSVTGN--ARQMSRDPPVPSNPTDHQISH 78 
XP_013969215   1 MSSVGKTPRGSEAMSETVVKIIGSKHFRYLSEKPKIKENENLKAETQTVLQKSMIGG--ARQISRDSPTPTNPTDHQINH 78 
XP_002750932   1 MSAVWKTPRGSDAMPEIMVKIIGSKHFRYLVEKPKINENENFITETQTMHQEPMTDN--ARQMSRDPPAPVNFTDQQTND 78 
KFO23170       1 MSSVQKTPDGSDTMPEITVKIIGSKYFRCLVEKPKNRQEENLQAGTLVALKKPTMDT--TGWAEREPLAPPKPSAQHTGN 78 
XP_006238482   1 MSSPWKTPPSSAPKPEMIVKIIGSKHFRYFVEKPMIRQNETLKTEPQTPLPEPGTDY--SRQVRRDLPGPTDSSEQQISA 78 
XP_007480550   1 MSSSWDTPYRRAAMPETVVKIIGSKHYRFLVEKPKMQVKENITAKAQPDLGPLVPRH--GRQLGENPLALNSFAEPKVKF 78 
XP_005326066   1 MSSVWKTPPRSNAMPDIVVKIIGSKHFRYLAEKPKIKQNENLEVETETTLQNPRTGN--ARQMSKDTPAPTDPSDHKTMD 78 
XP_014348002   1 MSSSGETPFGTDTTPEIIVKIIGSKLVRYYVEKPKKILEQAVKTETGSIKPPLDSGSqiQKRLRTSPCNATSRPGGQCYG 80  coelacanth
XP_003793175   1 MSAVWKTPRGSDAMPEITVKIIGSKHFRYLVEKPKIKEDENMKTEMQTVVQKPKTGN--AGQMSRDPPAPTNLADEQTNC 78  small-eared galago
XP_005204562   1 MSSVWKTPRGSNAMPEMMVKIIGSKHFRYLVEKPKIKENQNLKAETQTVLQKSVTGD--AKPIGGDPPALTDPTDHQINH 78  cattle
XP_020953281   1 MSSVWRTPRGSDAMPEMVVKIVGSKHFRYLVERPKIKEDENLKAETQIVLQKSVTDx--ARQTSKDPPVPANPTDHQINL 78  pig
XP_006096178  79 GPDDVQE--------NKPPENNQKLLTGALGSRLLDGK-----VPKQANVYCSSVPTGDQSLSYIHGLPRRKLRDWSLEQ 145
XP_013969215  79 DLDDKEEskh--penNQKPENNQKFLAGARSNRFLDGK-----IPSQANVYCSSVPTGDQSLSYIHGLPRRNIRDWSLER 151
XP_002750932  79 NPDDVKEnkh--tenNQKSENNQKLLTGVHNSRFLDVK-----IPGRADVYCCSVPAGDQSLSYVHGIPRRKLRDWSLEQ 151
KFO23170      79 LPGDGDQqgskhrdnAPQPEDNQQLPAGTCSSTYVDGR-----ISHHANVYCSSVPTGDQSLSYMHDLPRGKLRRWSMEQ 153
XP_006238482  79 HPAEKEEs-------GQKPESNQKFLTTVLGNRFLDDM-----ISHGANVHCSSVPAGDQSLSYMHSLPRRKSIDWCLEN 146
XP_007480550  79 NPDFREQn------kVGNKEDKSISIGAGNSSRLLGSG-----MLKWADAQCSSVPSGDQSLSFLHGLPKPSPIDWSLEH 147
XP_005326066  79 NQDDMEEgkh--panNQKPENHQELLTGTYCGRFLDGK-----VPHQA--HCSSVPSGDQSLSYMHGLPRRNLRDRSLEQ 149
XP_014348002  81 KDTDKDEersfemgkNNSQSKGNE-------------------ASKPLDVQCITAPTGDQSLSYIHGPRKPFQRSQALQS 141 coelacanth
XP_003793175  79 SPDDEEEskr--pgnTQRPGSSQRLLTGAHGSRFLGGKafvvwIPIQAQGRCISVPTGDQSLSYVHGLPRRKLRDWSLEQ 156 small-eared galago
XP_005204562  79 DPDDVKEskh--qenNQKPEDNGKLLTGALSCRFLDGK-----VSNQANVYCISQPTGDQSLSYIHGLPRRNFRDWSLEQ 151 cattle
XP_020953281  79 DPDDVEEnkh--pesHQKPEDNQKL-----SCRLLDNK-----IPNQANIYCSSVPTGDQSLSYIHGLPRRNLRDWSLEQ 146 pig
XP_006096178 146 -MERGSSDQPEDIGQRLSGtTKE---DTFLLALVRRELKAHSLSTGLLDKLQKELKILDPIASGFLLQSQLSRLFLKHEV 221
XP_013969215 152 -MARGSSDQPEDFGQKPSG-TRE---DAFLLALVRRELRSCPLNAGLLEKLQKELMTLDPISSGFLLQSQLNCLFLRHEV 226
XP_002750932 152 -MVRGGSDQHEDIGQRPRGtTNE---DTFLLALVRRELKSRPLRSNLLEKLQTELKILDPISSGFLLQSQLSHLFLRHEL 227
KFO23170     154 -RAGGHTCQPEDIAPKASEmTRE---DAFLLTLVKRELKPHPLSSSLLDQLQEELKAMDPLSSGFLLQPHLSCLLLRQEI 229
XP_006238482 147 --TKDNSGQAVEVVRRPSVmTRE---DSFLIALVRRELNSCPLSSNLLDKLQKELKTLDPISSGFLHQSQLNRLFLRHKV 221
XP_007480550 148 -MSRNGPCGLESLGLRSSE-------DESLLAMVGREFKVHPPGPNLLEMLEKELKVLDPISSGLLLQSQLSRLLIKHEL 219
XP_005326066 150 -LVRGGSSQPEDTIQRPSGtTKE---DSFLLALVRKELKSHPLSSRLLDKIQKELTILDPISSGFLLQSQLSHLFLRHGV 225
XP_014348002 142 yTTSGDHKNDHQTGIPSTRtRNApsvDGPLLTIVRSELKSDSLSE--LEKVKVELQSLDPDLSGFIHQSQMSLVFLRHEL 219 coelacanth
XP_003793175 157 mMSSGSAQXXD-FDQRPSGtMRE---DSFLLALVRRELKSHLLSPGVLDKLLKELKILDPISSGFLLQSQLSHLFLKHQV 232 small-eared galago
XP_005204562 152 -MARSSSDQPKDIGQRPSGtKKE---DTFLLALVRRELKSLPLSSGLLDKLQKELKVLDPVSSGFLLQSQLSHLFLRLEV 227 cattle
XP_020953281 147 -MARDSSDQPKDIGQRPSGpIKE---DIFLIALVRRELKSHPLSPGLLDKLQEELKILDPVSSGFLLQSQLTHLFLRFEV 222 pig
XP_006096178 222 PLQLPTVKILCQRFARSGSPEMVNYEKLLCFLKVAASDDPQQSRRAVNSSPREAQGGTHHSesaA--PQHADSPSEV-TR 298
XP_013969215 227 PLQLPTVKILCQRFSRRDTPEMVNYGKVLRFLKAATSDDPKQSTRAVGSNPMKTQSCHHHSq--RttLHDASPQSEV-SQ 303
XP_002750932 228 PLQLPTVKILCQRFSKRGSPEMVNYEKLLWFLNSAASDYSQQNKAVAD--QRKTESHGNHSq--StpPQHSSTQPEV-NR 302
KFO23170     230 PLQGPTVQLLCQRFSRSGSPKMVCH---LALLNRALLRSLPCATRIIVKGLSVFEVRKGIL---StlPQPSDNDQ----- 298
XP_006238482 222 PLPLPTLKLLCQRFSRRDSPEGVNYGELLCFLKEATKDNLQQNGTAVYSNPRKTPSLSQDKq--StpPQDSSLLSDV-NK 298
XP_007480550 220 PLQLPTVKLLFQRFTQTRYSELVNYKKLLWFLRLAVSRETQRSDPPADDIPGKKENSN---------NLGPSSSSEA-TD 289
XP_005326066 226 PLQLPTVKILCQRFSRKGSPEMVNYEKLLWFLKSAASDDLQQCKTVVDSNLKKTQSQSDPKr--RtpPQDSSSPSEG-DK 302
XP_014348002 220 PLQLPTVRLLFDKFSEPTNPELVNYEELLHFLMTAASFEDHNAAHLTYSPPTKT---------------DNEKLLFIgDE 284 coelacanth
XP_003793175 233 PLQLPTVKILCQRFSRRGSPEMVNYGKLLLFLRGAASDNLQQSKTTADSNLGHPEHLSDHRq--SapPHDSSSRSEA-NK 309 small-eared galago
XP_005204562 228 PLQLPTVKILCQRFSRGSSPEMVNYEKLLWFLKVAASEDTEQNKGVEDSNVKETQSSS-HQ---SiaPQDYNSQSEV-NE 302 cattle
XP_020953281 223 PLQLPTVKILCQRFCGMGSPEMVNYEKLLWFLKVATSDDPQQDK-S------------------StaPQDSSSQSDV-NK 282 pig
XP_006096178 299 --SLLEILKlALSTANGKLNPESLSRSFRKEDHALSGFLSLPKVRAICGKHGLYLTLSLLETLLNHQDLAYQNEIKWQNF 376
XP_013969215 304 --NLLEILR-ALRTTSGKLDIEGLRLSFRKEDRSFSGSLPPPKVRAICGKHGLYLTLSFLETLLNHQDLGYHGEIKWQNF 380
XP_002750932 303 --GLLEILKmALRTTNGKLNIDNLNLSFRKEDRSFSGCLPPPKVRAICGKHGLYLPLSLLETLLSHQDLGYQNEIKWQNF 380
KFO23170     299 --SLLEILKmVLQTASRHLNIENLNLNFRREDRSFSGCLPPPKVRAICGKHGLYLTLSLLEILLNHQDLGYQDEIKWQNF 376
XP_006238482 299 --SLLQILKmALRTYQGKFSVDCLNLNFQKEDHSFSGCLPLPKIMSICSKHGLHITMTLLETLLHHQDLGYRGEIKWKNF 376
XP_007480550 290 --NIIELLRsALKTSKDELNLENLHLSFQKEDQPFSGHLPPSKIKPICEKHGLILSPSLMEAMASHQDLNIQDEIKWQKL 367
XP_005326066 303 --SLLEILRmVLRTTNGKLNIENLNLSFRKEDRSFSGCLPPAKVRAICGKHGLYLTLSLLETLLNHPNLGYQDEIKWQNF 380
XP_014348002 285 daKFLQLLAeAIKDCNGAVDLRRLRLSFQDTDRMDTGLLPKHEVKAICQKHLPSIPPLLLEGLVN-KTWYQRSMVQWKKL 363 coelacanth
XP_003793175 310 --SLLELLKmALKTANGKLNTENLGLSFRKEDHSFSGCLPPPKVRAICGKHGLYLSLSLLETLLNHQDLGYQNEIKWQSF 387 small-eared galago
XP_005204562 303 --SLLEVLKmALRATKAKLNIEKLNLSFRKEDRSFSGCLPPPKVRAICGKHGLYLTLSLLETLLNHQDLGYQNEIKWENF 380 cattle
XP_020953281 283 --SLLEILKmTLRAAKGKLNMENLNLSFRKEDHSFSGYLPPPKVRAICGKHGLYLTLSLLETLLNHQDLGYQGEIKWQNF 360 pig
XP_006096178 377 VELLSRASSDLSSDLPT--GEFRKETSA-----------TAVQAEVPEMSQGKFEHMK-----SPEE-ELQPE--NLPAE 435
XP_013969215 381 VELLSKAFSDLSHDLPA--GKHVKKTSG-----------TAVPAEVPEMSPGKTEHMK-----TPEE-KLPSE--HRPAE 439
XP_002750932 381 VEILSRASADLLSDLPT--GKNEKKASA-----------PPVEPEVPELSQSKTEHMK-----TPEE-ELQPE--NSPAE 439
KFO23170     377 VELLKRASLDLLSGLPT--GKYEQEVPA-----------SPGQSEVPEVPQSQTEH-Q-----TAEE-ELQPK--NPPAE 434
XP_006238482 377 VKWLNRASSDLQYDMPA--GKNKKEVQE-----------NLV--NIPEGTQRNTEYVK-----TSEK-NLQPK--T--ST 431
XP_007480550 368 MEFLVKASSDGSSSLPQpsGTEKEEVPF-----------SVAATKGSEAVQSLTEDLK-----QTEDgEPPPA--NPALE 429
XP_005326066 381 VELLSRASSDLLSGLPP--GKNEKEAPA-----------ISEQPEVSEISQTKAEHMK-----TPEE-KLNPG--NPPAE 439
XP_014348002 364 VELLDRSLSFKHTNVPSvtRKL--EFTTsqhheqqgkenKKISATAPPYIDHKFLQNSqglqgKSEE-PLNYAesSYPEA 440 coelacanth
XP_003793175 388 VEMLRRASSDLLADLPT--GKNEKDAPA-----------TPVQPKDPETSQSKTEHMK-----TPEE-ELQAE--TPAAE 446 small-eared galago
XP_005204562 381 VEWLGRASSDLSSDFPP--GNKGKEISA-----------TPGHPEAPEISQGETEQMK-----TPEK-DLKPE--NPPAE 439 cattle
XP_020953281 361 VKLLSRASSELSPDLPT--GKKGKETSP-----------APAQPEVPEVSQGKTEHMK-----TPEE-DLQPE--NPSAE 419 pig
XP_006096178 436 MSAPKDPLSSLTIRPVSQPFVSP-VMENKSEEC-EMWIDRFRKLENALYLCDLSNTGILEKERARRLIHNYNLIYNLSLS 513
XP_013969215 440 ISAPDDPLQALKVRPVSQPFVSPmMMKKESEEQ-EMWINRFRKLENALYLCDLSNTGVLEKERARRLIHNYNLIYNLSLS 518
XP_002750932 440 TSASKDPLNSLKIRPVSQSLVNP-AMKNEVEEC-ETWIDRFRKLENALYLCDLSNTGVLEKERARRLIHNYNLIYNLSLS 517
KFO23170     435 TSALEDSLSPLKIRPVSQPLLSS-AMKNGSEEHkETWIDRFRKLENALYLCDLSNTGNLEKERARRLIHNYNLIYNLSLS 513
XP_006238482 432 TSAPEGPVTAFKYRPASEPGEHRaMMKDEQP---ELWIDRFRKLENALYLCDLSNTGVLEWERAKRLIHNYNLIYKLSLS 508
XP_007480550 430 TRASR------QIRPASQPYLSQ--LGNEETQR-ETWMDRFRKLENALYLCDVNHTGVLEKERARRLMHNYNLIYNLALS 500
XP_005326066 440 TPTPNDPPSSLKIRPVSQPFLSR-AMKNRSEEC-ETWIDRFRKLENALYLCDLSNTGVLEKERARRLIHNYNLIYNLSLS 517
XP_014348002 441 P-VPKDQ----ESSPVIQPFHGK-SKSSSFKES-ETWLERFNRLEKALRMCDSKNTGILEKDKARRLIHNYNLIFDLCLS 513 coelacanth
XP_003793175 447 TSAPKDPLSSLQIRPVSQPFMSP-AMRNKSEES-EMWMDRFRKLENALYLCDLSNSGVLERERARRLIHNYNHIYNLSLS 524 small-eared galago
XP_005204562 440 TSAPKDILNALKIRPISQPSVSP-VMKNAAEEC-ETWIDRFRKLENALYLCDLSNTGVLEKERARRLIHNYNLIYNLSLS 517 cattle
XP_020953281 420 TSAPKDLLSAVKIRPVSQPFVSP-VMKNASGEC-EIWSDRFRRLENALYLCDLSNTGVVEKERARRLIHNYNLIYNLSLS 497 pig
XP_006096178 514 PRKIDQALRRFRSGENMLLEPALRYLKEL 542
XP_013969215 519 PQKIDQALRRFRVGENMLLEPALQYLKEL 547
XP_002750932 518 PRKIDQALRRFRLGENMLLEPALRYLKEL 546
KFO23170     514 PQKIDQALRRFCSGENLLLEPALRYLKEL 542
XP_006238482 509 PRRIDQALRRFRSGENIILEPALQYLKEL 537
XP_007480550 501 PLKIDQAVRRFRVGENLLLEPTLRYLKEL 529
XP_005326066 518 PRKIDQALRRFRSGENMLLEPALRYLKEL 546
XP_014348002 514 PLKIDQGFHSFQHGGNIKLEPILQYLKEL 542 coelacanth
XP_003793175 525 PRKIDQALRRFRSGEDMLLEPALRYLKEL 553 small-eared galago
XP_005204562 518 PRKIDQALRSFCAGENMLLEPALRYLKEL 546 cattle
XP_020953281 498 PRKIDQALRRFRAGENMLLEPALQYLKEL 526 pig
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