1ITU


Conserved Protein Domain Family
rDP_like

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cd01301: rDP_like 
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renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics. Although the biological function of the enzyme is still unknown, it has been suggested to play a role in the renal glutathione metabolism.
Statistics
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PSSM-Id: 238626
Aligned: 30 rows
Threshold Bit Score: 269.118
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitedimer interface
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1ITU; Human renal dipeptidase with bound dipeptyl-inhibitor cilastatin

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            # #                                                              #         
1ITU_A       15 PVIDGHNDLPwqlldmfnnrlqd-----------------eranlttlagthtNIPKLRAGfvGGQFWSVYTPCdtq--- 74  human
NP_421542    48 LTLDTHLDTPahfgrpgwdiad--------------------hhevehdfsqvDLPRMNQGglDGGFFVVYIGQgelte- 106 Caulobacter cres...
BAC14648     48 IVVDSHIDTMmnvldentwlpt--------------------ldiaestslhiDMQKLKESgiDVGYFAAFTTDygy--- 104 Oceanobacillus i...
NP_905813   282 IVLDSHVDTPmhfcpefdf--------------------------tkrgntlvDAPKMREGlvDACVMVAYLPQgerdd- 334 Porphyromonas gi...
ZP_00095596 345 TIVDLHADTLmwrrnltd----------------------------raaqghvDLPRLIDGhvALQVLSSVTKSpkglny 396 Novosphingobium ...
NP_644656    41 VTLDSHLDTPanleradfdvl---------------------qahrgnrlsqvDYPRMVEGalDGGFWAVYTGQgdrsa- 98  Xanthomonas axon...
NP_643293    26 CPVDTHLDSLylsrlggfdfwkgdwkahrrspilwlmsktsprgrnqplmyhvSGPDFLAGgyGGACFSAHALWenlvg- 104 Xanthomonas axon...
ZP_00087119  86 LSFDSHITVLqdfgthgne-------------------------adkdgpgqfDLIKANRGqlSGAALTIFGWPelwn-- 138 Pseudomonas fluo...
NP_887321    21 LAADLHRDAVvvdg-----------------------------------lvffSDGSTRDMl-AGGVSAINLTVtem--- 61  Bordetella bronc...
NP_885666    55 IVVPSATDMAtrftqdsfvf------------------------dclsmyyviDDPWAENCl-AAGVNATNVTFgteqpw 109 Bordetella parap...
Feature 1                                                                                       
1ITU_A       75 -----------------------nkdAVRRTLEQMDVVHRMcrmypetflyvts-----------sagirqafregkVAS 120 human
NP_421542   107 ---------------------kgytyARDYALHRTIEIREMlaanpdtfemalt-----------sddarriakagkKFA 154 Caulobacter cres...
BAC14648    105 -----------------------terNLSRTLALINALYWTaennqksmtists-----------ldeikdtlandkIAI 150 Oceanobacillus i...
NP_905813   335 ---------------------aslkqATDYATGKLEAIRSQvlshpeslmqatn-----------peevreakrrglCAI 382 Porphyromonas gi...
ZP_00095596 397 danpsnsdtitalavtqmqpvrtwnsLLERSLWHAEKLDRAvagssgelvkvtgqa------slddllrergegalpVGA 470 Novosphingobium ...
NP_644656    99 ---------------------aahldDRDAGLQRLLRIHTLvaaqsqrfalatt-----------padaarikaagkRVV 146 Xanthomonas axon...
NP_643293   105 ---------------------apfldPWKHWVEHRRYVQEMvaasggrmrlars-----------aaelrairaaglCCA 152 Xanthomonas axon...
ZP_00087119 139 ----------------------ganaPHKPTAGFVEEARNQqeirykiisgmvrdfpnqvgiaytpedfrrlhgegkFAI 196 Pseudomonas fluo...
NP_887321    62 ------------------------saDFEQALKDVMAWRQRcqdpasgwtlver-----------aadiarakregkLGL 106 Bordetella bronc...
NP_885666   110 ---------------------divlrDFDSGLEKIERSPYLalatnrqei-------------------daankqgkLAV 149 Bordetella parap...
Feature 1           #                                                                           
1ITU_A      121 LIGVEGGHsid--------ssLGVLRALYQLGmrYLTLTHscntpwadnwl--vdtgdsepqsqGLSPFGQRVVKELNrl 190 human
NP_421542   155 FVSMENSWpvg--------edLSLVETFYKEGlrMAGPVHfrnnqladss-----tdpkgkiwnGYSPLGLRWLAEANrl 221 Caulobacter cres...
BAC14648    151 VPTIEGGYsfsq------ensIELVQQYKDLGikAIGFNWnysnilgegad--evyldgrsssgGLTTTGEELVQEMNrl 222 Oceanobacillus i...
NP_905813   383 IPGIENGYaig--------keLANIERFRDMGvcYITLCHngdndicds------arktkhehnGLSDFGREVVREMNrl 448 Porphyromonas gi...
ZP_00095596 471 MLSIEGLHdle--------gkRENLDRLYDAGfrMASLTHffdnqlag--------smhgerkgGLTPFGRQIVRAMEdk 534 Novosphingobium ...
NP_644656   147 YISMENASplv--------adPTLLRFYYAQGlrLMSTVHflnnefadsa-----tdpkgaqwnGLSPAGKQLVQQAQal 213 Xanthomonas axon...
NP_643293   153 ILSLEGAHmlgprgrrsqalrIARLESAARAGaaYLTLNHfshtdisqagya-slnpwrerqgaGLTEFGRQVVERCIdi 231 Xanthomonas axon...
ZP_00087119 197 FISMLNAYplg--------hdLNLLDLWTARGmrMFGFSYignndwadssrplpffndspdaldGLSDLGKQAVKRLNdl 268 Pseudomonas fluo...
NP_887321   107 IMGWQNARplg--------drLERIALFHTLGmrVIQLTYneanligd--------gclekrnaGLSNLGIEMVREMNrv 170 Bordetella bronc...
NP_885666   150 IIGTQGSAmvd--------leFHRLRTMHRLGmrYFGLAYtgptmfad--------gcgesrnaGLSFAGIELIDACNdl 213 Bordetella parap...
Feature 1              #                       #                   #                            
1ITU_A      191 gvLIDLAHVsvatmkATLQls---rAPVIFSHSSAYSV---------CASRRNVPDDVLRLVkqtDSLVMVNFynnyisc 258 human
NP_421542   222 giVIDVSHAsddvvdQSVAls---kAPIIASHSGPKAV---------YDHPRNLDDARLKKIadaGGAICINSiyltdtt 289 Caulobacter cres...
BAC14648    223 gmIVDVSHMsrdtfwDVIEtt---eAPIMATHSGVEEL---------RSHQRNLTDEQLQAIkenNGVVGIVFypvflse 290 Oceanobacillus i...
NP_905813   449 gvMVDISHAavstvrDVLQis---sAPVVASHSSSRAL---------CNHTRNLTDEDALAIarsGGVVQVCLyagfise 516 Porphyromonas gi...
ZP_00095596 535 gmIVDIAHLshpgvaELLAma---rRPVVSSHGGVQAT---------CKVNRNLTDAEIRGVartGGVIGIGYwdaaic- 601 Novosphingobium ...
NP_644656   214 giVIDQSHAsdavfdQLIAls---pVPIVLSHSGARAV---------YNHPRNIDDARLKVLaahGGVIQVNSyggylvd 281 Xanthomonas axon...
NP_643293   232 glLVDLSHTssqgirDACGiclrrnVPAFVSHGASRSVtrgvetrpsRHLDRALDDAAIRAIvqtGGCISVILapyflqh 311 Xanthomonas axon...
ZP_00087119 269 gvIIDVSQMstkaleQVAQls---rTPMVASHSAPRAM---------VDIPRNLSDKELQLIknsGGVVQVVGfsqylrp 336 Pseudomonas fluo...
NP_887321   171 giAIDLSHCaeqtclDAARhs---tRPVLLTHANANAV---------IARPRNKSDAVIKAVaatGGVIGCSIhaylnwr 238 Bordetella bronc...
NP_885666   214 glILDLSHVghrsreETVAr----sRFPVCTHSNSYAL---------NPNDRNTTDETARAIrakGGIMGICGlpktvhp 280 Bordetella parap...
Feature 1                                                                                       
1ITU_A      259 --------------------------------------------------------tnkanlsQVADHLDHIKEvag-ar 281 human
NP_421542   290 psperkaalealgrapdmkta---------------tpeavkayadkraaidkahpaargdfdLYMKSMLHVLKvag-pk 353 Caulobacter cres...
BAC14648    291 --------------------------------------------------------nnqatinDIVDHIDYVVDlig-id 313 Oceanobacillus i...
NP_905813   517 q-------------------------------------------------------eeegsvqHAADHIDHFVRllg-ie 540 Porphyromonas gi...
ZP_00095596 602 ----------------------------------------------------------dtsprAAARAMRHVRDlvg-iq 622 Novosphingobium ...
NP_644656   282 sgasperkaaekaltdqyggwe------------hvkiadgtklsvalkdldarypikrateeDFFAHLEHILAvvg-pe 348 Xanthomonas axon...
NP_643293   312 syladgtp-----------------------------------------dmdadlafvvgyyeAFARQIAAMGIvedpwk 350 Xanthomonas axon...
ZP_00087119 337 ltqttqdklnelrksfdlpplpnlavalmpgdpiiaawpeakfgqyasrlyaildeepkatlkDYGDAIDYTVRkig-id 415 Pseudomonas fluo...
NP_887321   239 gq-----------------------------------------------------agqqptldDFVANIRYIGDlvg-ye 264 Bordetella bronc...
NP_885666   281 ---------------------------------------------------------enatlnELLDHADHWVKtid-aa 302 Bordetella parap...
Feature 1             #  #                                                                      
1ITU_A      282 aVGFGGDFDGvprvpeg---------------------------------ledvskYPDLIAELLRrnwteaEVKGAlAD 328 human
NP_421542   354 gVCVGADWDGgggmdg----------------------------------feditdLPKITARLKAegysdaDIEAIwSG 399 Caulobacter cres...
BAC14648    314 hVAIGSDFDGadlpsd----------------------------------mkdstdLPLLTKELENrgysdeDIRKIlGE 359 Oceanobacillus i...
NP_905813   541 hVGVGSDFDGdgelvg----------------------------------crgandLINLTVELLRrgytrdQLGLLwGE 586 Porphyromonas gi...
ZP_00095596 623 hVALGSDFDGatttr------------------------------------fdtsqLEQVTQALLDegfsddEIRAVmGL 666 Novosphingobium ...
NP_644656   349 hVGIGMDWDGgggvvg----------------------------------ledvsdLPRITAWLLRkgyteqQIAGIwGG 394 Xanthomonas axon...
NP_643293   351 hLSFGSDFDGgisslpt--------------------------------gmrsgadLPKLTQAMLDagwptqRIVDVySG 398 Xanthomonas axon...
ZP_00087119 416 hVGISSDFNEgggvkg----------------------------------wenvgdIPNVTAELISrgyseaDIAKLwGG 461 Pseudomonas fluo...
NP_887321   265 hVGIGTDFPAvdtyeavrhvmvmsrtkyaasggdfsnafgdvmearypvetptpaqFGGLTEALARgglsdaQIRGVlGG 344 Bordetella bronc...
NP_885666   303 hVGFGLDFVEayksdrstmpaasrlwrtrrpd--ifgtveefhlqdyplgiasikqLPNLTQGLFDrgyaekEVAGIiGG 380 Bordetella parap...
Feature 1            
1ITU_A      329 NLLRV 333 human
NP_421542   400 NVLRI 404 Caulobacter crescentus CB15
BAC14648    360 NSLRV 364 Oceanobacillus iheyensis HTE831
NP_905813   587 NFLRV 591 Porphyromonas gingivalis W83
ZP_00095596 667 NALRV 671 Novosphingobium aromaticivorans
NP_644656   395 NLLRV 399 Xanthomonas axonopodis pv. citri str. 306
NP_643293   399 NFMRI 403 Xanthomonas axonopodis pv. citri str. 306
ZP_00087119 462 NFLRV 466 Pseudomonas fluorescens PfO-1
NP_887321   345 NFVRA 349 Bordetella bronchiseptica RB50
NP_885666   381 NWLRH 385 Bordetella parapertussis

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