Conserved Protein Domain Family
PTH2_like

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cd02429: PTH2_like 
Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in bacteria and eukaryotes and Pth2 present in archaea and eukaryotes. There is no functional information for this eukaryote-specific subgroup.
Statistics
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PSSM-Id: 239107
Aligned: 11 rows
Threshold Bit Score: 155.64
Created: 14-Apr-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                          #   #  #                               #                   
NP_650561   4 IVQYIVVRSDlr-saLSWPLGAVIAQSCHATAAVIHLNSEdadt-----vayLNDLDNMHKVVLEAKDe----sALVKLS 73  fruit fly
EAA01514    3 LVQYVIVNGEi---aKSWPKGALIAQCCHAVAAVGHLYASdpdt-----veyFKDLDNMHKVVLEAPDa----gKLVSLG 70  Anopheles gambiae ...
CAI21155   12 LVQYVIVRSDli-hsLSWPLGAVITQACHAATAAIHLHYSdpdt-----qqyLAELDSMHKVVLQAPDe----aSLSTLS 81  zebrafish
CAC08244   71 VVQYVVLRRDl---iDSWPLGSVVTQGCHASVAAIWSFKDdpvtl---qycdPQHIDSMHKVTLEVKGe----tQMMNLS 140 thale cress
EAL19369   23 LVMQIIVRRDll-teHKWPVGPLLAQSAHAATAVLHRFRDhpdvkrylkgedGRGWETMRKVVLEVPDe----aALKSLA 97  Cryptococcus neofo...
AAF60890  100 YVMYVILRRDlq-tkLGWPLGAVCTQAAHAASASMWIFRNdpnt-----eayTSNLDSMHKVTLGVDSe----eEIKKVA 169 nematode
XP_420022  26 LVQYVVLRGDl---aRSWSLGAVVAQGCHAALAAAHAHWHhpdt-----rayLSAGGAMRTVVLEAPDe----aALTALA 93  chicken
NP_703767   6 IIQYILVNKEii--dKKWPLGSVIAQACHACVAVIAENMDdeivk---dylsPEHINNMHKVILKIDDt----nEIKNLS 76  Plasmodium falcipa...
XP_770256   7 ITQYIVLRND-----LPWGLGALAAQVAHASVAAIHAFREhpdv-----rvyLSDISNMRKVVLSADEq-----QIIQLR 71  Giardia lamblia AT...
CAI76366    8 LTQYVILREDlqtdgKPWPRGALIAQACHACISVNSLYNSdegvi---kytsFENLPNLRTVVLSVENe----sSLLDYH 80  Theileria annulata
XP_757504  38 LVMQLIIDGTss-skLGWPKGPWMAQSAHAAISAIQVSLSssltq---ayisPSNLASMHKVVLQTAAsgkskmTLRELS 113 Ustilago maydis 521
Feature 1                                                  #                         
NP_650561  74 EKLKe------------------------nEIKHKLWieqpENIPTCIALKPYVKdt---vHKYVKHLKLL 117 fruit fly
EAA01514   71 EVLQq------------------------nDVKHKVWveqpENLPTCIALKPYPKee---vQKYMKKFKLL 114 Anopheles gambiae str. PEST
CAI21155   82 STLEe------------------------kDIAHKLWmeqpENIPTCLALKPYPKet---vQPYLKKFKLF 125 zebrafish
CAC08244  141 EKLKl------------------------gGISHKLWmeqpENIPTCIATKPYPKsq---vSSFFKKLKLC 184 thale cress
EAL19369   98 SKIDdm----------------------anPVGYHMWieqpENTPTALALVPNKRpkglkrAFDEVGCELF 146 Cryptococcus neoformans var...
AAF60890  170 DKLTa------------------------rNVDHKVWi--eDGFPVCIALKPYPKee---vKNALKGLKLF 211 nematode
XP_420022  94 QTLQq------------------------hSIDHEVWteqpENVPSCLALRPYPKdq---vHPHLKRFKLL 137 chicken
NP_703767  77 SILDk------------------------eSLKYKIWteypENIFTAIALKPYYKnt---vRDYFKKYPLL 120 Plasmodium falciparum 3D7
XP_770256  72 DDLCa------------------------aKIDHFAWieqpENLLSAIGLRPCPKel---vRPYLKHLSLL 115 Giardia lamblia ATCC 50803
CAI76366   81 KVLTn------------------------nLIKSHLFtekpENIVTCLATVPIDKrk---vGSLLKKLKTF 124 Theileria annulata
XP_757504 114 QKLTearkayqeayaakpsaqqihegdeneFPMHYLWveqpENVPTCLAIAPNRKp-----ASLKKILRSC 179 Ustilago maydis 521

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