Sperm-associated microtubule inner protein 10
This family (previously DUF4513) represents homologs of Sperm-associated microtubule inner protein 10 (SPMIP10). SPMIP10 is a microtubule inner protein (MIP) part of the axonemal dynein-decorated doublet microtubules (DMTs). It plays a role in the stabilisation of the interacting protomers of TEKTL1 - a tektin-like molecule that forms a filament in the cleft between protofilaments A11 and A12 . In the EM structure of sperm DMTs, SPMIP10 cradles the inter-TEKTL1 interface while interacting with protofilaments A11 and A12.
Jiyao W et al.(2023). "The conserved domain database in 2023.",