6IIQ,1N27


Conserved Protein Domain Family
PWWP_HDGFL3
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cd20150: PWWP_HDGFL3 
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PWWP domain found in Hepatoma-derived growth factor-related protein 3 (HDGFL3)
HDGFL3, also called HDGF-related protein 3 (HRP-3), is the only hepatoma-derived growth factor (HDGF)-related protein (HRP) family member whose expression is almost restricted to the nervous tissue. It enhances DNA synthesis and may play a role in cell proliferation. It contains a PWWP domain, which is necessary for DNA binding.
Links
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Statistics
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PSSM-Id: 438978
Aligned: 8 rows
Threshold Bit Score: 171.784
Created: 9-Jan-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:6IIQ: Human HRP3 PWWP domain binds a 16-bp TA-rich DNA; contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                      # ####                                                    # #     
6IIQ_A         5 PRPREYKAGDLVFAKMKGYPHWPARIDELPEGAVKPPANKYPIFFFGTHETAFLGPKDLFPYKEYKDKFGKSNKRKGFNE 84  human
1N27_A         4 GSSGEYKAGDLVFAKMKGYPHWPARIDELPEGAVKPPANKYPIFFFGTHETAFLGPKDLFPYKEYKDKFGKSNKRKGFNE 83  house mouse
NP_001012372   4 PRPREYKAGDLVFAKMKGYPHWPARIDELPEGAVKPPANKYPIFFFGTHETAFLGPKDLLPYKDYKDKFGKSNKRKGFNE 83  zebrafish
KQK78742       4 PRPREYKAGDLVFAKMKGYPHWPARIDELPEGAVKPPANKYPIFFFGTHETAFLGPKDLFPYKEYKDKFGKSNKRKGFNE 83  blue-fronted am...
XP_005989672   4 PRPREYKAGDLVFAKMKGYPHWPARIDELPEGAVKPPANKYPIFFFGTHETAFLGPKDLFPYKEYKDKFGKSNKRKGFNE 83  coelacanth
XP_007905209   4 PRPREYKAGDLVFAKMKGYPHWPARIDELPEGAVKPPANKYPIFFFGTHETAFLGPKDLLPYKEYKDKFGKSNKRKGFNE 83  elephant shark
NP_001096550   4 PRPRDYKAGELVFAKMKGYPHWPARIDELPEGAVKPPANKFPIFFFGTHETAFLGPKDLFPYKEYKEKFGKSNKRKGFNE 83  tropical clawed...
Q9Y3E1         4 PRPREYKAGDLVFAKMKGYPHWPARIDELPEGAVKPPANKYPIFFFGTHETAFLGPKDLFPYKEYKDKFGKSNKRKGFNE 83  human

Feature 1                     
6IIQ_A        85 GLWEIENNPGVKF 97  human
1N27_A        84 GLWEIENSGPSSG 96  house mouse
NP_001012372  84 GLWEIENNPGVKF 96  zebrafish
KQK78742      84 GLWEIENNPGVKF 96  blue-fronted amazon
XP_005989672  84 GLWEIENNPGVKF 96  coelacanth
XP_007905209  84 GLWEIENNPGVKF 96  elephant shark
NP_001096550  84 GLWEIENNPGVKF 96  tropical clawed frog
Q9Y3E1        84 GLWEIENNPGVKF 96  human

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