1D5Y,3E0H,3Q5S


Conserved Protein Domain Family
GyrI-like
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pfam06445: GyrI-like 
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GyrI-like small molecule binding domain
This family contains the small molecule binding domain of a number of different bacterial transcription activators. This family also contains DNA gyrase inhibitors. The GyrI superfamily contains a diad of the SHS2 module, adapted for small-molecule binding. The GyrI superfamily includes a family of secreted forms that is found only in animals and the bacterial pathogen Leptospira.
Links
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Statistics
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PSSM-Id: 428947
Aligned: 66 rows
Threshold Bit Score: 54.3373
Created: 22-Mar-2022
Updated: 13-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1D5Y_B 125 EHKFVTLEDTPLIGVTQSYSCSLe--qISDFRHEMRYQFWHDFLGNaptIPPVLYGLNETRPSqdkdDEQEVFYTTALAQ 202 Escherichia coli
O26725  22 EISEKMVEGIRVAYIECRGSYER----IPEYISEVAGWVLKNGLQ----MTGRVYGTYYNTPEe--vDEEELLYEIGVSI 91  Methanothermobacter t...
Q8YZW0 140 EVVIKKVAPIQVASIRQILPDNPs---IGQLYGEISEYLAQNGVK----AGDYYAGIWHDPGYk--dTDIDAEAVISIEG 210 Nostoc sp. PCC 7120
Q8A8H8   6 EIMLLQQPEQPALAIEVQTYMKGmsqaIGENFVRIDSLFKKQGE-----VTTDIPFVEYPDFEs--lTEDRIKMIIGLKS 78  Bacteroides thetaiota...
3E0H_A   8 VCELKELAPVPALLIRTQTTXSElgslFEAGYHDILQLLAGQG------KSPSGPPFARYFg----xSAGTFEVEFGFPV 77  Chlorobaculum tepidum
Q8TS18 129 EPVIKEIPELRVLGKREKGTFVVt---IGKLINEICACVSSPENQRn--RVKTTGPIMFLCHDe---EYKETGADIEITL 200 Methanosarcina acetiv...
Q8TTD8   4 EVTIVELSPQPVLGIRKTGAYRE----IPVMLNRICEFAFSKNI------QITGYPVFLWHETt---VEEAQKAEVDENA 70  Methanosarcina acetiv...
P96690 122 QISKIKLPAMRVAYLQHEYVLGHd---IEHSLAELRTHLNVNED-----IFIGKIGLSISAANv--kAKQFDKYSSIFMI 191 Bacillus subtilis sub...
Q24YP1 122 KIEERTLKERKIAVLKKELAISDd---LEQPIRELAKRNSLHAV-----MFLGKVGVSISSANl--qRGNFDKFSAVFVV 191 Desulfitobacterium ha...
Q9RIX3 121 AVTLEELPARRVLAVTLDVPEGAg---LDWYDEAMCDVDSAAGER----SVLPPGGRYEHTLFt---EGHGRATVYVPFE 190 Streptomyces coelicolor

1D5Y_B 203 DQAD----------GYVLTGHPVMLQGGEYVMFTYEGLG-TGVQEFILTVYGtCMPMLNLtRRKGQDIERYYPAEDakag 271 Escherichia coli
O26725  92 AGEA----------EADERVKIKNLPSHRVIAALHEGPY-TEVGPVIHALIE-YAMENGY-EITGPVTEVYLNSPLe--- 155 Methanothermobacter t...
Q8YZW0 211 SI------------KGNERIKIYELPGSETTACLIHHGSyETLAQAYATLVS-WIEANGY-NITAPNREVYIIGGNe--- 273 Nostoc sp. PCC 7120
Q8A8H8  79 SKPL----------QGDEKIQSVILPARRIVVCLHRGNY-NELAQLYNEMTE-WIKTNGY-KASGTSIEYYYSNPd---- 141 Bacteroides thetaiota...
3E0H_A  78 EGGV----------EGSGRVVTGLTPSGKAASSLYIGPY-GEIEAVYDALXK-WVDDNGF-DLSGEAYEIYLDNPAe--- 141 Chlorobaculum tepidum
Q8TS18 201 PVSGrv-------sVEDPKMEIKTLPAMKAISVIYRGPY-HEVEVAYNRIFS-FAEENSL-ETILPSRELYFNDPAe--- 267 Methanosarcina acetiv...
Q8TTD8  71 DIEVafpisefvenTGDEEIKVYELPGGKMAKVVHEGPY-EESILTYEKLFF-WITENGK-RIAGPVREVYLNDPQe--- 144 Methanosarcina acetiv...
P96690 192 LED-----------ENEKTSSEIIFPSREYLQIRFKGSH-PEAEPYYKKLLA-YMKEHHY-EVAGDSIEITLIDYGit-- 255 Bacillus subtilis sub...
Q24YP1 192 IEP-----------EDNCQENLSCLPGGNYLTLRFQGTH-PDAEASYIKMLQ-YMKENGY-ELAGDSLEFALIDYGlt-- 255 Desulfitobacterium ha...
Q9RIX3 191 APLPp---------EMPGRVRELHLPRRTAAVATHQGRH-DDLDLTYGAVGS-FAARNDL-RSQDLVEEVYLVGPRdt-- 256 Streptomyces coelicolor

1D5Y_B 272 dRPINLRCELLIPI 285 Escherichia coli
O26725 156 vDESELLTEVQIPV 169 Methanothermobacter thermautotrophicus str. Delta H
Q8YZW0 274 qNNDSYVTELQFPV 287 Nostoc sp. PCC 7120
Q8A8H8 142 vPEEEHVTRVEMPL 155 Bacteroides thetaiotaomicron
3E0H_A 142 tAPDQLRTRVSLXL 155 Chlorobaculum tepidum
Q8TS18 268 vPEEELMTEVQVQF 281 Methanosarcina acetivorans
Q8TTD8 145 vKPEEILTEIYAPL 158 Methanosarcina acetivorans
P96690 256 nNLDNYVTEILLPI 269 Bacillus subtilis subsp. subtilis str. 168
Q24YP1 256 nDPSKFITELQIPY 269 Desulfitobacterium hafniense Y51
Q9RIX3 257 dRPELWRTLVAWLI 270 Streptomyces coelicolor
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