5VCM


Conserved Protein Domain Family
MGAT2

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pfam05060: MGAT2 
N-acetylglucosaminyltransferase II (MGAT2)
UDP-N-acetyl-D-glucosamine:alpha-6-D-mannoside beta-1,2-N- acetylglucosaminyltransferase II (EC 2.4.1.143) (GnT II/MGAT2) is a Golgi resident enzyme that catalyzes an essential step in the biosynthetic pathway leading from high mannose to complex N-linked oligosaccharides. Mutations in the MGAT2 gene lead to congenital disorder of glycosylation (CDG IIa). CDG IIa patients have an increased bleeding tendency, unrelated to coagulation factors.
Statistics
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Structure
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PubMed ReferencesClick to see Conserved Features Help

pfam05060 is the only member of the superfamily cl24173
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5VCM_A        64 RSLVYQLNFdqtl---rnvDKAGTw----------APRELVLVVQVHNRPEYLRLLLDSLRKAQGIDNVLVIFSHDFWST 130
Q9FT88        80 RNHFSPRNT----------DLFPDl----------AKDRVVIVLYVHNRAQYFRVTVESLSKVKGISETLLIVSHDGYFE 139 thale cress
Q69QZ8        89 RNALPPRNA----------DRFPRl----------PDGHLNIVLYVHNRPRYLRLVVDSLSRAHGIGEALLIVSHDGYFP 148 Japanese rice
ABF70149     133 RNKLPPRNM----------DRFPNl----------AKDHTKIVLYVHNRPQYLRLVVSSLAAVEGISETMLIVSHDGYFA 192
CDS40406     121 RNHILSINEaqyi---hniDRFGK-----------ASPLFIIIIQVHQRYTHLLYLIESLRRVRGIEEALVVFSHDFFSP 186
CCD75454     113 RQYISHINMvqyv---kneDLYGQlptrdnfnstrSSPNHVIIIQVHNRSIELSLLIESLRRTKGIETALIIFSHDFYSD 189
XP_009858387  74 RNKAISMNFdqem---knvAKFGMh----------APDSVIFLLQVHSRPEFVQQLINSLRASTGIEHATVVISVDVDSP 140
EFO25555      79 VRSIEFLNAnyei---lntDKYGHl----------QNVEIVLVVQVHDRIEYLKELISTLRAARYIETALLIFSHDYSSA 145
O17560        99 VESVSFLNEnfdi---lnaAKFGDl----------STVKTILVIQVHDRPVYLQYLIESMRNTKGIEDTLLVFSHDINVG 165 Caenorhabditis ...
OWR49661      67 KNVINDANRkqsteddemdWDFSF----------------IIVIQVYRGINNLNHLVDGLKQAKGIGTALLLFSHSFYSK 130
5VCM_A       131 EINQLIAGVNFCPVLQVFFPFSIQLYPNEFPGSDPRDCPrdlPKNAALKLGCINAeyPDSFGHYREAKFSQTKHHWWWKL 210
Q9FT88       140 EMNRIVESIKFCQVKQIFSPYSPHIYRTSFPGVTLNDCK---NKGDEAKGHCEGN--PDQYGNHRSPKIVSLKHHWWWMM 214 thale cress
Q69QZ8       149 EMDKIVQTITFCQVKQIFAPYSPHLFPEAFPGVSSGDCQ---GKDKAAEKHCQGD--PDQYGNHRSPRIVSLKHHWWWMM 223 Japanese rice
ABF70149     193 EMDRIVQDIRFCQAKQIFAPYSPHLFPDGFPGVSPGDCH---DKDDPIVTKCNGT--ADQYGNHRSPRTVSLKHHWWWMM 267
CDS40406     187 EINRMIAAIRFVRFTQIFFPYSRQIFLNSFPGPDPRDCH------TRGAKNCLNHewPDIAGNYRDARFAQVKHHWIWKL 260
CCD75454     190 ELNSLIGSIRFTRTVQIFYPHSMQIFPDTFPGTDPRDCDsriKPAEARNIECLNArwPDTFQHYRESHFTQIKNHWLWKI 269
XP_009858387 141 EINEVLARIDFCRYMVIFFPFAKVLYPNSFPGEDPNDCPkkiPKAQALERKCNNAeyPDMFGNYREVDFVQIKHHWFWKL 220
EFO25555     146 VINKLIRGIDFCLVMQIFYPYSIQLFPDVFPGLDPLDCPekaTKKEAASLKCNNWknPDKYGHFRVAKLTQIKHHWWWKM 225
O17560       166 IINEMIRNITFARVYQIFYPYNLQLFPTVFPGQSPSDCPekmKRDKAQETNCSNWssPDKYGNYRVAQLTQIKHHWWWKM 245 Caenorhabditis ...
OWR49661     131 DINRVVRNISFARVLQIYYPYSVQLHPFVFPGYDQKTC--------DEVMSCRKSd--------RKALVIQHKHHWWWSA 194
5VCM_A       211 HFVWERVKILRDY---AGLILFLEEDHYLAPDFYHVFKKMWKLKQQECPECDVLSLGTYSASRsfygm-adkvDVKTWKS 286
Q9FT88       215 NTVWDGLEETKGH---EGHILFIEEDHFLFPNAYRNIQTLTRLKPAKCPDCFAANLAPSDVKS----------RGEGLES 281 thale cress
Q69QZ8       224 NTVWDGLDETRDF---DGHILFIEEDHYIFPNAYRNAQLLVDLKPSKCPQCYAINLAPSDVKA----------KGEGWES 290 Japanese rice
ABF70149     268 NTVWDGMEETKGF---SGHILFIEEDHYIYPNAYRNLQLLIGLKPMKCPECYAANLSPMDVNS----------IGEGWDM 334
CDS40406     261 CFVINKMNISKSF---NGQYILLEEDYIVLKDMLHVLSLAKKLNTSF----DIIALGSYENLQtyns--seilHETYWIS 331
CCD75454     270 EFVMNHFYPTKYY---EGYFILLEEDHFVVEDILHVSELISKNVWSPLKTDGIIALGSYDKDNnyls---nvvELTYWLA 343
XP_009858387 221 NMAFSGIRAFNNQ---KAPIILLEDDYFVVPDIIHCAKQAEELRKSKCPRCQTISLGNYEQTQdyqaq-gnqvEIKSWIS 296
EFO25555     226 NYVFDGI--LKQYaltKVWVILLEEDHYVSPDFLHVMRLIVGSKSNFCAECQVISLGLYLKQYnnfksnlnrlGIHPWFS 303
O17560       246 NFVFDGI--VEKYsmkDPWVLLLEEDHMLAPDALHVLDIIVSNRPKYCENCEIISLGFYLKSTnkygqdiahlGVHPWYS 323 Caenorhabditis ...
OWR49661     195 SFVFDRVFATRNY---NGTILFLEENQYVTSDFIYIFRILDGLLRSSNLHCDIISLGNGKSKSssyrlinssiLLKPWDT 271
5VCM_A       287 ----TEHNMGLALTRNAYQKLIECTDTFCTYDDYNWDWTLQYLTvscLPK-FWKVLVPQ-IPR--IFHAGDC-GMH-HK- 355
Q9FT88       282 lvaeRMGNVGYSFNRSVWENIHQKAREFCFFDDYNWDITMWATV---FPSfGSPVYTLR-GPRtsAVHFGKC-GLHqGRg 356 thale cress
Q69QZ8       291 lvaeKMGNIGYAFNRTVWRKIHAKAKQFCTFDEYNWDITMWATV---YPSfGSPVYSLR-GPRrsAAHFGKC-GLHqGQg 365 Japanese rice
ABF70149     335 lvaeKMGNVGYSFNRTVWRKIHTKAKEFCSFDEYNWDITMWATV---YPSfGTPVYTLR-GPRrsAAHFGKC-GLHqGRg 409
CDS40406     332 ----SKHNMGMAFTKNLFQKLEPYWKNFCIYDDYNWDWSLYFIDrvcASE-KLRVLHFKnCGR--VFHTGSC-GLH-NKg 402
CCD75454     344 ----PKHNMGMAVSRVVWKNIEQCLNLFCFYDDYNWDWSLQYIGqncFPG-KLKALTLPlSTR--VFHSGECrGLH-HQk 415
XP_009858387 297 ----SKHNLGMVVSSDFYNKIANCAEQFCNYDDYNWDWSLQAVSphcEMG-NLFTLAFK-ATR--VFHLGSC-GVH-SKg 366
EFO25555     304 ----SKHNMGMAIKADTWELIKNCTELFCKYDDYNWDWSLLRVSmkcLPS-RLKVIAVK-APR--VIHVGDC-GIH-THr 373
O17560       324 ----SKHNMGMALQKNTWQKIKGCSEMFCKWDDYNWDWSLMQISakcLPQ-RFRVIFTK-SPR--VIHIGDC-GVH-THr 393 Caenorhabditis ...
OWR49661     272 -----RETLGIAFNKDTWKTVKNLSEHFCRYNDNRWSKSLIHLSt-kTSLgKFYALSIE-GSR--VFRLNKC-----KDh 337
5VCM_A       356 Kt--C-RPSTQSAQ-IESLlnnnk--qymfPETLTISEKFTv------VAISPPRKN-GGWGDIRDHELC 412
Q9FT88       357 DegdC-IDNGVVNIeVKET-----------DKVVNIKEGWGvrvykhqAGYKAGFEGwGGWGDDRDRHLC 414 thale cress
Q69QZ8       366 LsnvC-VDNGDATVqLDAI-----------DKVPNIKANWPvhiikrqEGYQAGFKGwGGWGDKRDQELC 423 Japanese rice
ABF70149     410 KsssC-IDNGEARFqLDEI-----------DKILNIKPDWKvhvvkkqSGYQAGFKGwGGWGDERDRELC 467
CDS40406     403 Se--CdNVEASVVGvMERVargggsdeglfPATLMVKMAT--------VQRSAVPPN-GGWGDARDRALC 461
CCD75454     416 Ts--C-STELLVTNiLQMFsgpll--trlyPTSLHLSEKIH-------TENIKQRVN-GGWSDERDRSLC 472
XP_009858387 367 E---C-NAKQSAESrTAQLqnq-----klyPESLHIAVDSP-------TVVPAPRPN-GGWGDLRDQTLC 419
EFO25555     374 ----C-AVHNTAAV-AAELfsssa--nslfPKKMILAENLK-------RTLKPPREN-GGWGDIRDHELC 427
O17560       394 ----C-EAHKALQS-TQELfrqhk--dllfPTSLSVTDTSR-------RSLKPSKEN-GGWGDIRDRQLC 447 Caenorhabditis elegans
OWR49661     338 Kt--C--NETKNNEiLLNFvrkir--kklfPFKMHIVKSN--------SVEEVGEGN-GGWTDVRDHELC 392
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