Conserved Protein Domain Family
FKBP_N_2
?
pfam18023: FKBP_N_2 
BDBT FKBP like N-terminal
This is the N-terminal domain of the beta chain found in Drosophila melanogaster protein BDBT (a FK506-Binding Protein) which stimulates the DBT circadian function. The domain contains the DBT-binding site. The domain is structurally homologous to the peptidyl prolyl isomerase (PPIase) regions of FK506-binding proteins despite low sequence homology. BDBT is structurally related to the immunophilin FKBP51 and it shares a common domain organization consisting of PPIase-like and TPR domains with noncanonical immunophilins such as FKBP38 or FKBPL.
Links
?
Statistics
?
PSSM-Id: 375495
Aligned: 8 rows
Threshold Bit Score: 118.301
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
KMQ87854       4 WKSADKSISKNVLKPAiY-TKKPTERSTCNVLVEKL-NVTGASDEDLREKYhteIldgEGEKVLVIGEASAEIDRKIESA 81 
XP_003428224   4 WESADKLIKKEIIREG-QfSNKPTELSVCTIHVANPqSLDLSIEQMKENLYsdiId-aDSKKVIVIGDACSHVDRYIERA 81 
KZC06647       6 WESADKIVRKDVINPGfF-LWKPTECASCGVLIENIqVVNTSADDLKEKFNs-tIldgTNEKTLVIGEANCEIDCHIERA 83 
1_pfamImport   1 WEDTKKGIGKTTISFDsKhLIAPTEVSKVSVIFSNVqNLENRKSKFLEKID--------SKVEIQMGSALNPIDFYIEIL 72 
XP_001990405   9 WSDEMRGLHKKVLSLDfQtVEKPLAVSSVLFTVNKS-CVGSRPTKYLNCAE-------MQQHAMKMGSAVTPIDCYLELL 80 
KNC32574      13 WKLERKGLYKKVQALEfTkVEKPHQVAKVIINVEQVeNLKDRETQWLNANT---L---NKDQIMEMGSALTPIDYYLEIL 86 
XP_014790634   8 WTSPNNSISKEILKFGsG-LARPTDGSICIVSISHIgGATLNKDS-LGY-G---L---GENVKIQIGEGDTILGELIDEC 78 
EEN52322      31 WQAPDQSFAKYILEKG-RgIETPNLGASCVVQILPL--VSEGLEQGLVGYP---M---YEENEIVLGEGDTEISEVLDAC 101

KMQ87854      82 IHMMNIHERSLVTITIP-AKQSEVNn-rSITVKFEITLIKCER 122
XP_003428224  82 IEMMSLNEHSLITVQFP-PDRTRTE---TIILSLEVTLEKVDF 120
KZC06647      84 IQMMNIHEKSVVTLNIS-LENNDK----PLIIKFEVTLTKMEP 121
1_pfamImport  73 LGHLKKGELAKCFIKTS-AM-E---------ITFNIKIIEIEN 104
XP_001990405  81 LQQFLPGETAVCSIATK-TGEQ---------LEFELKLDRITS 113
KNC32574      87 VQQMMLGETAECTIKTKtPGED---------IKIVLTLQEIKQ 120
XP_014790634  79 LESMKLDECCEATFHIL-LESSKDScdqFEKYKFQLELHKFEN 120
EEN52322     102 FETMQAAEVCEVEVAKE-TVGMGTG---DDPIRFQLELKEFTR 140
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap