Conserved Protein Domain Family
SIKE

?
pfam05769: SIKE 
SIKE family
This family consists of several eukaryotic proteins. Suppressor of IKBKE 1 (SIKE) is a physiological suppressor of IKK-epsilon and TBK1, which are two IKK-related kinases involved in virus- and TLR3-triggered activation of interferon regulatory factor 3 (IRF-3). Other members of this family are circulating cathodic antigen (CCA), found in Schistosoma mansoni (Blood fluke), and FGFR1 oncogene partner 2, which may be involved in wound healing pathway.
Statistics
?
Structure
?
PubMed ReferencesClick to see Conserved Features Help

pfam05769 is classified as a model that may span more than one domain.
pfam05769 is the only member of the superfamily cl47935
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_002402068   2 SVSVQQILGEARRLVGRLREQDSSADQLLAQA----HTLGQGVEAMR---QYNEE--LSQLATNSSvgtglPRPRAALVL 72 
ESO13052       4 SMMMEKLLNDAKQLTVRLKERDEMADKLISTT----MNIQCKLCSMK---QYQNE--VDELNKTAR-----HRPKILLIQ 69 
Q0IG53         2 SVTFEQIILDAKRIANRLKDREALGDSLLLES----ESVNKQIESMR---QFQDD--IDILNKLAR-----DRSNNQLIT 67  yellow fever mo...
EDW51932       3 NLSVGQIIMDAQRMASRVKDLDALGTALLEEA----ENNNRLVESLR---QYQDD--IESLNRISN-----NKTNADMVN 68 
XP_015781940  11 ISDINKIVQDAKDLYEKLIEDEETANQLLCKA----TFLNNAAVTMV---EYQDI--IDDLDEDSK-----DNPNPSQTS 76 
XP_004995271  73 GQGRNKTLAVAERVRKAVDGHLDAADKAMELAakarSRLKHSIEVKA---ALRDVtaVKGESKATQatdtsSG------- 142
EDQ89777       1 MET-EQQLQAVKALSARLSQDAHSAEAMVKQAlelkHLLEKNLELMGtsqAASEE------------------------- 54 
XP_001954507   7 TGTLGGVLKKTHELVSGLDEMQVTTDSLISLG----ESVNQDLVNCS---KYRDElvLKHLTEHSK-------------- 65 
XP_001999166   5 ADAVTGLIIKAQKVSSDFNDLIQKTTCLLADC----ESVDKKFFDSC---GVQEDqlLKNLVKYCN-------------- 63 
EFX71933       2 SVSVQQILADAKRLAGRLKDHDSSADLLLSQA----QAMFCQVDAMK---EYQEE--LVELNTAAH-----QRPHLDLIA 67 
XP_002402068  73 SIQQENRHIRELQQENRELVATLKEHQSALELIMAKYREQVTRLGSTCQAEEKLGIGA---------SAASALAalpqch 143
ESO13052      70 QLAKENAKIRDLQHENTELKQSLEEHQSTLGVIMNKYREQVENLNTTQQLEETFVRNNd--------NYSEDLE------ 135
Q0IG53        68 IIHQENPQIREIQQENRLLKAALEDHQHALEHIMTKYREHTQSKILNTKVNFVEAFSKhqq---fneQKDEVIR------ 138 yellow fever mo...
EDW51932      69 RIQQQNINSSEILKENRELKIFIEDYERAMELMMQKYREHTVSKVLDSKFSFKELYNE---------RMWQVIR------ 133
XP_015781940  77 AIITESRQLNQLQNENAQLKMALEDHQFALELIMSKYRQQVCRFLNYQKCQKMPMIKSs--------CSTETVH------ 142
XP_004995271 143 ----DAQFLKDLVHENRELHAFVGEMKTTMQVVVDHRRKQIDELLRIQDEARADAARTkqeaddkvaALEKEVT------ 212
EDQ89777      55 ----QEGWLTDMAKENYELHAMVDELLSALHVLMQKHRQQVSALRTRNQETVEDAQRQieaerqrsrRLELEVV------ 124
XP_001954507  66 ----DDQQVMLL-RENAELRNTVDEYQKGIELIMSKYREHSDGNIFDDTYAVRERYVS---------GMSKIVD------ 125
XP_001999166  64 ----DDERIQQL-LENAELKQTVEDYKEGVKIIMEKFRKHCQQNVLGERFNLRRRYVG---------QLQEMVN------ 123
EFX71933      68 NIQQENRQLRALENENKELKSALEEHQNTLELIMSKYRQQISRLLEASHTEKNLVHLL---------PDTRKAE------ 132
XP_002402068 144 HLADKVCEMAAVMRRAA---EVDEE-RDAKETELLTRLKAENGVLRQLLEIG 191
ESO13052     136 KKEEKLKEMASVMMMASehwETNSK-DRNEEQRLINLLQDKNKIIREVLFSQ 186
Q0IG53       139 QQTQKIQEMAAVMQRAS---QLDEE-KFNQEQEFLSKLITENKGLRELLEIS 186 yellow fever mosquito
EDW51932     134 EQREKINEMAAVMQLAA---SVDDG-VVQRELQTISQLRLENETLRELLQIS 181
XP_015781940 143 QLSTRIKDMSQVMMDAI---EADED-SQVKRDRIISQLKVENDTLRELVKIA 190
XP_004995271 213 RLNAKIEEMQQVMCAAV---EADAGtSVDALAQEIARVETENSQLRELLLVC 261
EDQ89777     125 QLTSKIEEMEKVMCAAV---AVDER-DDLDLIADVVAVAQENQQLRDLLRVS 172
XP_001954507 126 DQDARIEHMLQMMKLTA---DLEEI-DSEGNQRIIRQLTGENEEMRRQLQIS 173
XP_001999166 124 NLEKRIEEMTLIMLCSI---SVEEH-NSNENQRIIRQLTKENDEMRRKLQIY 171
EFX71933     133 EQAEKINDMIGVMETAI---KLDDS-YVQKEIELFSKLTTENRVTRRAVPNV 180
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap
HHS Vulnerability Disclosure