Conserved Protein Domain Family
AKR_galDH
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cd19163: AKR_galDH 
L-galactose dehydrogenase (L-galDH) and similar proteins
L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Links
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Statistics
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PSSM-Id: 381389
Aligned: 40 rows
Threshold Bit Score: 368.032
Created: 16-Apr-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Rattus norvegicus voltage-dependent K+ channel beta subunit (3EAU) in complex with cortisone and cofactor NADPH.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                          ###                              #    #                       
O81884         4 IELRALGNTGLKVSAVGFGASPLGSVFgp-vaEDDAVATVREAFRLGiNFFDTSPYYGgt-------lSEKMLGKGLKal 75  thale cress
CBY18872       1 MKIVELGKTGIRVQKLGLGAGPFGSIYgd-tnEKECRDTLTKALESGpLYIDTAPWYGqg-------kSEKMLGKFLPd- 71  Oikopleura dioica
XP_003384049  10 MLYRDLGRTGMRLSIVGLGGSGWGKNYgp-ydEKEAVRAFHHALDRGvNYIDTAYWYGqg-------hSEKFLGQHLLpt 81  Amphimedon quee...
XP_789690     18 MRYHDLGNTGMKVSIIGFGAAPLGRVYdadlpEEQGVAALQHALRGGvNYIDTAPFYGqg-------kSEAVLGKALKd- 89  purple sea urchin
SFB87255       1 MKYNTLGKTDLLVSKLGFGASGIGGMFgk-tnETEAIKTIHQAFDRGiNYFDTSPAYGrndskfgpltSEITLGKGLTt- 78  Algibacter lectus
SDB50034       1 MLYRKLGNTDIEISAVSFGTGSLGELFgp-ldEGDALRLVDEAIDSGiNFIDTSPFYGs---------AEYRLGKALPg- 69  Bauldia litoralis
SJM67369       2 TQYRELGGTGLTVSTVSFGTGSLGELFgp-ldDADALRLVDEVIDSGiNFIDTSPYYGs---------AEERLGKALTp- 70  Gulosibacter sp...
OEO32890       1 MKRNPLGRTGLAVSALSFGASALGGVFrp-vdVSEAIATVHAALEAGiNYFDVAPAYGgg-------rSESLLGKALKg- 71  Devosia insulae
NP_863775     33 LPRRRLGQTDMELTTLSFGASSIGQEFrs-vdLGESLQAVRVALDSGmNFIDTAAFYGrg-------mSEMMLGRVLPd- 103 Rhodopirellula ...
EAZ79345       1 MEYRKLGKTDMEVSILGFGASPLGNVFde-ctEKEALETVAHAIDHGiNFYDVSPFYGlt-------lAEERLGKALEs- 71  Algoriphagus sp...

Feature 1                   #                                           ##                       
O81884        76 qvPRSDYIVATKCGRYke-------gFDFSAERVRKSIDESLERLqLDYVDILHCHDIEFgsl---dqIVSETIPALQKL 145 thale cress
CBY18872      72 -iPRDKFVIATKVARYdtdp---kkmFDFTHDRALASVDESLKLLgLDYVDIIQVHDCEFapn--idiILNETLPALEKV 145 Oikopleura dioica
XP_003384049  82 -vSRDRYFIATKVGRYeldl---pnmFNFTAERVTKSLEESLRRLqLSEVDIIQIHDVEFsls--vnqILHETLPALERL 155 Amphimedon quee...
XP_789690     90 -vPREAYYIATKVGRYeldv---kgmFDFSADRVTRSIDESLKRLgLDYVDLIQVHDVEFass--ldlIIDETLPALEKI 163 purple sea urchin
SFB87255      79 -iDRSKIVISTKAGKTasl----ppeFNFKYQSIINSVEASLKRLqTDYIDMVFLHDIEYdkgkyfnlAMDEGLKALRKL 153 Algibacter lectus
SDB50034      70 --KRDKVILGTKAGRYgv------tdFDYSARRVRESVETSLRLMnTDYLDILQLHDIEHvpl---erVLNEGYAALAQL 138 Bauldia litoralis
SJM67369      71 -aKREQVLIGTKTGRFgr------ddFDFSPARIRSSLERSLRLLgTDHVDVFQLHDVEYvdl---dpVFEDGVAELHAL 140 Gulosibacter sp...
OEO32890      72 -iDRSHYVLSTKVGKYtdperygsdtLDYSAERIRLSLEASAARLgTDYFDLIHIHDIEYqgrskleqALTEGLETVLAL 150 Devosia insulae
NP_863775    104 -iPRDQYYLGTKLGRYtg------ehFDFSAKRVTESIDTSLERMkVDHLDIVLCHDLEFvem---sqIVEETIPAIRRE 173 Rhodopirellula ...
EAZ79345      72 --KRKEIFLASKCGRYgl------qeFDFSKKRILKSIDESLSRLkTDYVDLLQLHDIEFvdk---sqILEEAIPAIEEI 140 Algoriphagus sp...

Feature 1                   ##                       #                           #######         
O81884       146 KQEGKTRFIGITGLpLDIFTYVLDrvppgTVDVILSYCHYGVNDSTL-LDLLPYLKSkgVGVISASPLAMGLLTEQg--- 221 thale cress
CBY18872     146 KKAGKAKFIGVTGYpLAVLDEIIKks-tvKIDLVLGYTRGSMVNQDL-SKFLPDWKErgIAVVNASPIAMGLFRKNg--- 220 Oikopleura dioica
XP_003384049 156 KEKGLCRHIGITGYpLGPLKEVISqs-svQIDSILSYCRLSLNDWTL-KNEFQFFKEnkVPIINACPVSMGLLTEGp--- 230 Amphimedon quee...
XP_789690    164 REEGKARFIGLTGYpIQVLRSIVErs-kvKIDTVLSYCHLSLNDSSL-LQHVTFFQErnIGLISASPLSMALLTDRg--- 238 purple sea urchin
SFB87255     154 KEDGKIRFYGVSGYpIELITSVIEn---hQVDAILAHNHHTLINNLL-LKLIPKAKEkkISLINASPFASGLLTKKg--- 226 Algibacter lectus
SDB50034     139 RDEGKCRYVGMTGYpLATMRRVMTd---vDLDVLLTYAHGTLLDNSI-GDLQTLAQErgVGLINAAALTLGLLSPGgsnv 214 Bauldia litoralis
SJM67369     141 KDEGKARCIGMSGYpLKTFARAYEr---tGIDVSLTYAKSTLLDSSLdEVLAPIAERngVALINAAAVSLGLLTPGgs-n 216 Gulosibacter sp...
OEO32890     151 KREGRIGAVSFGIYpMDLWARLFAd---yPIDAALVHNHYCLNDTRL-TTLLPTAEAsgIGVINASPFASGLLTERg--- 223 Devosia insulae
NP_863775    174 IAKGKVRYVGVSGYpMKMFKYVMAn---tDIDCLLTYNHYTLQNDMA-LELVPLAKEkgVGLMNGAPFSARLLTNAe--- 246 Rhodopirellula ...
EAZ79345     141 KSSGKARYIGITGLpVRYLAQIARe---vEIDTVLSWAHYNLLEDEInDELVPLSKEkgFGLMNAAPLMQRILSDAp--- 214 Algoriphagus sp...

Feature 1                                     #                 ####    #  ##              
O81884       222 pPEWHPASPELKSASKAAVAHCKSKGkKITKLALQYSLAnk-eISSVLVGMSSVSQVEENVAAVTELESLGMDQ 294 thale cress
CBY18872     221 pQPWHPAQNELKEEIKDCIELCNAENiDISRLALRYSLDei-dGDIVLCGTARPAELDENIKNATTPLTPSEKF 293 Oikopleura dioica
XP_003384049 231 vQDWHPSLPWIRDACNRAVQYCREQGvDITKLALHYSTSfe-eAVTTLVSMCDTEMVDKNLDSALSPLTPHEEG 303 Amphimedon queenslandica
XP_789690    239 pPSWHPAHYEIKKACHLAVAHCKQHGhDLSELALKYSISyvnaVPLTLIGMESKEQVDKNLKAVHDGPSDEQEQ 312 purple sea urchin
SFB87255     227 pPDWYPVTETQLFTVKKAIDFCLKNGvPIEKIALQFSLEnp-eIATTLFSCTEEKTLNQNIDWIEEPIDVLLIK 299 Algibacter lectus
SDB50034     215 sFFEHPASAAIQQSAAKMIALSKQRGvDLAFIANQYAIQes-gCATTVVGVGKSRHLASAVDAVSTPIDAGLLA 287 Bauldia litoralis
SJM67369     217 mVGEHPATPPIRRAAAAMIALAEKRGaDIAFLANQFSIQrt-rAATTVVGTGRSRHLQSALRAAETPIDEQLLA 289 Gulosibacter sp. 10
OEO32890     224 pADWHAASAEDRALFRRAAELCTERGvSISELAFQFATShp-aIPTTMFSTASPASLRRCLEWHGKAADPQLVA 296 Devosia insulae
NP_863775    247 lPPWHKATPQVREVAAAAAKHCADRGsDIAKIALQFSIAne-dFATCIPGSANPNRVAQWVEWAQEPIDETLVA 319 Rhodopirellula baltic...
EAZ79345     215 lPDWHRSPDEVKAMQPKLLAICNKYGvRLSDVALRYAMDhp-aISSTIVGMNNKALVAKNLEAVDFEIPAELLD 287 Algoriphagus sp. PR1

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